Michael S Klein

US Patent:

7173102, Feb 6, 2007

Filed:

Mar 7, 2002

Appl. No.:

10/471028

Inventors:

William F. DeGrado - Moylan PA, US
Gregory N. Tew - Amherst MA, US
Michael L. Klein - Ocean City NJ, US
Dahui Liu - Wynnewood PA, US
Jing Yuan - Lansdale PA, US

Assignee:

The Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

C08G 18/00
C08G 63/00
C08G 69/02
C08G 71/02

US Classification:

528322, 528310, 528190, 528191, 528192, 528193, 528272, 528327, 428 59, 428123, 428357, 428409, 428543, 428152, 428153, 424 768, 424 7808, 424401, 424402, 424422, 424423, 424424, 424443, 427256

Abstract:

Facially amphiphilic polymers and articles made therefrom having biocidal surfaces are disclosed. The polymers can inhibit the growth of microorganisms in contact with the surface or in areas adjacent to said biocidal surface. There is also disclosed a method to identify and optimize the facial amphiphilicity of polyamide, polyester, polyurea, polyurethane, polycarbonate and polyphenylene polymers. Utility as a contact disinfectant is disclosed.

US Patent:

7590517, Sep 15, 2009

Filed:

May 28, 2003

Appl. No.:

10/446171

Inventors:

Robert Doerksen - Philadelphia PA, US
Bin Chen - Baton Rouge LA, US
William F. DeGrado - Media PA, US
Michael L. Klein - Ocean City NJ, US

Assignee:

The Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

G06G 7/48

US Classification:

703 11

Abstract:

Methods, systems, and computer program products for computational polymer processing including, without limitation, computational amphiphilic polymer design, conformational energy minimization, generation and refinement of torsional parameters for sub-units of potential polymers, generation of modified force field parameters, and prediction of conformational information for potential polymers. A target polymer backbone or portion thereof is identified. Small model compounds that have structural connectivities that are similar to structural connectivities of the target polymer backbone or portion thereof, are identified, whereby the combination of the small model compounds serve as a model of the target polymer or portion thereof. Gradient-corrected density functional theory (“DFT”) torsional potentials are calculated for the small model compounds, wherein energies are calculated at unconstrained and constrained geometries of the selected small model compounds. New torsional parameters are then obtained from the DFT torsional potentials.

US Patent:

8222456, Jul 17, 2012

Filed:

Jan 21, 2005

Appl. No.:

11/038787

Inventors:

William F. DeGrado - Moylan PA, US
Dahui Liu - Wynnewood PA, US
Gregory N. Tew - Amherst MA, US
Michael L. Klein - Ocean City NJ, US

Assignee:

The Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

C07C 211/27
C07C 279/06
C07C 233/77
A61K 31/135
A61K 31/155
A61K 31/16
A61K 31/132

US Classification:

564374, 564157, 564236, 564389, 514616, 514634, 514654, 514655

Abstract:

The present invention discloses methods of use of facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers, including, but not limited to, pharmaceutical uses of the polymers and oligomers as antimicrobial agents and as antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers, compositions of the novel polymers and oligomers, including pharmaceutical compositions, and methods of designing and synthesizing the facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers.

US Patent:

8234074, Jul 31, 2012

Filed:

Jun 12, 2003

Appl. No.:

10/459698

Inventors:

Carlos F. Lopez - Philadephia PA, US
Steven O. Nielsen - Philadelphia PA, US
Preston B. Moore - Philadelphia PA, US
Michael L. Klein - Ocean City NJ, US

Assignee:

The Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

G01N 33/50
G01N 33/48

US Classification:

702 19, 702 20

Abstract:

A coarse grain model that mimics a lipid molecule, such as dimyristoylphosphatidylcholine (DMPC), is used to simulate self-assembly of a lamellar bilayer starting from a disordered configuration. The coarse grain model is orders of magnitude less demanding of CPU time compared to all-atom models. An initial bilayer-like structure is generated from a disordered configuration of the coarse grain models using a Monte Carlo simulation. The initial bilayer-like structure is refined using a molecular dynamics simulation. For relatively small systems, the molecular dynamics simulation can be performed under constant volume or constant pressure conditions. For larger systems, the molecular dynamics simulation is preferably performed under constant pressure conditions.

US Patent:

8236800, Aug 7, 2012

Filed:

Oct 31, 2007

Appl. No.:

11/980785

Inventors:

William F. DeGrado - Moylan PA, US
Gregory N. Tew - Amherst MA, US
Michael L. Klein - Ocean City NJ, US
Dahui Liu - Wynnewood PA, US
Jing Yuan - Lansdale PA, US
Sungwook Choi - Philadelphia PA, US

Assignee:

The Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

A01N 43/58
A01N 43/60
A01N 43/54
A61K 31/50
A61K 31/495
C07D 239/42
C07D 471/04
C07D 471/22
C07D 487/04

US Classification:

514247, 514248, 514256, 514257

Abstract:

The present invention discloses methods of use of facially amphiphilic polymers and oligomers, including pharmaceutical uses of the polymers and oligomers as antimicrobial agents and antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polymers and oligomers and their compositions, including pharmaceutical compositions. The present invention further discloses the design and synthesis of facially amphiphilic polymers and oligomers.

US Patent:

8455490, Jun 4, 2013

Filed:

Jul 26, 2012

Appl. No.:

13/559065

Inventors:

William F. DeGrado - Moylan PA, US
Gregory N. Tew - Amherst MA, US
Michael L. Klein - Ocean City NJ, US
Dahui Liu - Wynnewood PA, US
Jing Yuan - Lansdale PA, US
Sungwook Choi - Philadelphia PA, US

Assignee:

The Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

A01N 43/58
A01N 43/60
A01N 43/54
A61K 31/50
A61K 31/495
C07D 239/42
C07D 471/04
C07D 471/22
C07D 487/04

US Classification:

514247, 514248, 514256, 514257

Abstract:

The present invention discloses methods of use of facially amphiphilic polymers and oligomers, including pharmaceutical uses of the polymers and oligomers as antimicrobial agents and antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polymers and oligomers and their compositions, including pharmaceutical compositions. The present invention further discloses the design and synthesis of facially amphiphilic polymers and oligomers.

US Patent:

20060041023, Feb 23, 2006

Filed:

Mar 17, 2004

Appl. No.:

10/801951

Inventors:

William DeGrado - Moylan PA, US
Gregory Tew - Amherst MA, US
Michael Klein - Ocean City NJ, US
Dahui Liu - Wynnewood PA, US
Jing Yuan - Lansdale PA, US
Sungwook Choi - Philadelphia PA, US

Assignee:

The Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

A61K 31/165

US Classification:

514616000

Abstract:

The present invention discloses methods of use of facially amphiphilic polymers and oligomers, including pharmaceutical uses of the polymers and oligomers as antimicrobial agents and antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polymers and oligomers and their compositions, including pharmaceutical compositions. The present invention further discloses the design and synthesis of facially amphiphilic polymers and oligomers.

US Patent:

20120202887, Aug 9, 2012

Filed:

Feb 3, 2012

Appl. No.:

13/365840

Inventors:

William F. DeGRADO - Moylan PA, US
Dahui Liu - Wynnewood PA, US
Gregory N. Tew - Amherst MA, US
Michael L. Klein - Ocean City NJ, US

Assignee:

The Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

A61K 31/155
A61P 31/12
A61P 31/10
A61P 31/00
A61P 31/04

US Classification:

514634

Abstract:

The present invention discloses methods of use of facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers, including, but not limited to, pharmaceutical uses of the polymers and oligomers as antimicrobial agents and as antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers, compositions of the novel polymers and oligomers, including pharmaceutical compositions, and methods of designing and synthesizing the facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers.