Michael W Knapp

US Patent:

7902639, Mar 8, 2011

Filed:

Nov 16, 2005

Appl. No.:

11/280986

Inventors:

Philip E. Garrou - Cary NC, US
Michael R. Knapp - Emerald Hills CA, US
Hash Pakbaz - Hayward CA, US
Florian Pschenitzka - San Francisco CA, US
Xina Quan - Saratoga CA, US
Michael A. Spaid - Mountain View CA, US

Assignee:

Siluria Technologies, Inc. - San Francisco CA

International Classification:

H01L 29/40

US Classification:

257622, 257623, 257624, 257625, 257626

Abstract:

Improved methods and articles providing conformal coatings for a variety of devices including electronic, semiconductor, and liquid crystal display devices. Peptide formulations which bind to nanoparticles and substrates, including substrates with trenches and vias, to provide conformal coverage as a seed layer. The seed layer can be further enhanced with use of metallic films deposited on the seed layer. Seed layers can be characterized by AFM measurements and improved seed layers provide for better enhancement layers including lower resistivity in the enhancement layer. Peptides can be identified by phage display.

US Patent:

56102879, Mar 11, 1997

Filed:

Nov 16, 1994

Appl. No.:

8/341148

Inventors:

Theo Nikiforov - San Diego CA
Michael R. Knapp - Baltimore MD

Assignee:

Molecular Tool, Inc. - Baltimore MD

International Classification:

C07H 2104
C12Q 168
C12N 1500
C12N 1108

US Classification:

536 243

Abstract:

Synthetic nucleic acid molecules are non-covalently immobilized in the presence of a salt or cationic detergent on a hydrophilic polystyrene solid support containing an --OH, --C. dbd. O or --COOH hydrophilic group or on a glass solid support. The support is contacted with a solution having a pH of about 6 to about 8 containing the synthetic nucleic acid and the cationic detergent or salt. Preferably, the cationic detergent is 1-ethyl-3-(3'-dimethylaminopropyl)-1,3-carbodiimide hyrochloride at a concentration of about 30 mM to about 100 mM or octyldimethylamine hydrochloride at a concentration of about 50 mM to about 150 mM. The salt is preferably NaCl at a concentration of about 50 mM to about 250 mM. When the detergent is 1-ethyl-3-(3'-dimethylaminopropyl)-1,3-carbodiimide hyrochloride, the glass support or the hydrophilic polystyrene support is used. When NaCl or octyldimethylamine hydrochloride is used, the support is the hydrophilic polystyrene.

US Patent:

55958702, Jan 21, 1997

Filed:

Aug 13, 1993

Appl. No.:

8/106143

Inventors:

Michael R. Knapp - New York NY
Philip Goelet - New York NY

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

C12Q 168

US Classification:

435 6

Abstract:

This invention provides a method of determining whether a nucleic acid molecule having a sequence of interest is present within a nucleic acid-containing sample which comprises the steps: (A) subjecting said nucleic acid of said sample to a treatment sufficient to fragment said nucleic acid and to produce a plurality of fragments derived from said nucleic acid; (B) fractionating said plurality of fragments; (C) contacting said fractionated plurality of fragments, under hybridizing conditions, with a reagent comprising a mixture of random or pseudorandom oligonucleotides, said oligonucleotides having a length a. gtoreq. 3 and. ltoreq. 1000 nucleotides; (D) detecting the pattern of hybrids that form from said contacting of said fractionated nucleic acid molecules and said oligonucleotides of the mixture of random or pseudorandom oligonucleotides; and (E) determining whether said nucleic acid molecule having said sequence of interest is present in said sample by determining whether said pattern is indicative of the presence of said molecule. This invention provides a method of obtaining a signature for a nucleic acid of interest and for constructing a restriction map of a nucleic acid of interest. This invention finally provides a method of identifying a nucleic acid sequence which encodes, directly or indirectly, a particular biological activity of interest.

US Patent:

20180321170, Nov 8, 2018

Filed:

May 25, 2018

Appl. No.:

15/990369

Inventors:

- Rockville MD, US
Deborah John Boles - Cary NC, US
Aaron Rulison - Los Altos CA, US
Wesley B. Dong - Belmont CA, US
Andrew Fabans - Los Gatos CA, US
Allen Boronkay - San Jose CA, US
Edward Donlon - San Jose CA, US
Robert Moti - San Jose CA, US
Michael Slater - Modesto CA, US
Steven A. Sundberg - San Francisco CA, US
Michael R. Knapp - Palo Alto CA, US

Assignee:

Canon U.S. Life Sciences, Inc. - Rockville MD
CALIPER LIFE SCIENCES, INC. - MOUNTAIN VIEW CA

International Classification:

G01N 25/04
B01L 3/00
B01L 7/00
C12Q 1/6862
G01N 21/33
G01N 21/64
C12Q 1/6844
C12Q 1/686
C12Q 1/68

Abstract:

The present invention provides novel methods and devices that employ microfluidic technology to generate molecular melt curves. In particular, the devices and methods in accordance with the invention are useful in providing for the analysis of PCR amplification products.