Michael J Knapp

US Patent:

6391622, May 21, 2002

Filed:

Jun 27, 2000

Appl. No.:

09/605548

Inventors:

Michael Knapp - Redwood City CA
John Wallace Parce - Palo Alto CA
Luc J. Bousse - Menlo Park CA
Anne R. Kopf-Sill - Portola Valley CA

Assignee:

Caliper Technologies Corp. - Mountain View CA

International Classification:

C12M 100

US Classification:

4352852, 435 6, 435 71, 435 911, 435 912, 4352831, 4352872, 536 221, 536 231, 536 243, 536 2431, 536 2432, 536 2433, 204450, 204451

Abstract:

Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components and drug screening are provided. Microfluidic devices, systems and methods for using these devices and systems for performing a wide variety of fluid operations are provided. The devices and systems of are used in performing fluid operations which require a large number of iterative, successive or parallel fluid manipulations, in a microscale, or sealed and readily automated format.

US Patent:

6403338, Jun 11, 2002

Filed:

Jun 27, 2000

Appl. No.:

09/605379

Inventors:

Michael Knapp - Redwood City CA
John Wallace Parce - Palo Alto CA
Luc J. Bousse - Menlo Park CA
Anne R. Kopf-Sill - Portola Valley CA

Assignee:

Mountain View - CA

International Classification:

C12P 1934

US Classification:

435 912, 435 6, 435 71, 435 911, 4352831, 4352852, 4352872, 536 221, 536 231, 536 243, 536 2431, 536 2432, 536 2433, 204450, 204451

Abstract:

Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components and drug screening are provided. Microfluidic devices, systems and methods for using these devices and systems for performing a wide variety of fluid operations are provided. The devices and systems of are used in performing fluid operations which require a large number of iterative, successive or parallel fluid manipulations, in a microscale, or sealed and readily automated format.

US Patent:

6409900, Jun 25, 2002

Filed:

Sep 19, 2000

Appl. No.:

09/664847

Inventors:

John Wallace Parce - Palo Alto CA
Michael R. Knapp - Aptos CA
Calvin Y. H. Chow - Portola Valley CA
Luc Bousse - Menlo Park CA

Assignee:

Caliper Technologies Corp. - Mountain View CA

International Classification:

B44C 122

US Classification:

204450, 204600, 204601, 156500

Abstract:

Microfluidic devices are provided for the performance of chemical and biochemical analyses, syntheses and detection. The devices of the invention combine precise fluidic control systems with microfabricated polymeric substrates to provide accurate, low cost miniaturized analytical devices that have broad applications in the fields of chemistry, biochemistry, biotechnology, molecular biology and numerous other fields.

US Patent:

6440722, Aug 27, 2002

Filed:

Jun 27, 2000

Appl. No.:

09/605692

Inventors:

Michael Knapp - Redwood City CA
John Wallace Parce - Palo Alto CA
Luc J. Bousse - Los Altos CA
Anne R. Kopf-Sill - Portola Valley CA

Assignee:

Caliper Technologies Corp. - Mountain View CA

International Classification:

C12M 136

US Classification:

4352852, 435 6, 435 912, 435283, 4352872, 435174, 4352891, 422 681, 436518, 436536, 536 221, 536 231, 536 243, 536 2431, 536 2432, 536 2433

Abstract:

Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components and drug screening are provided. Microfluidic devices, systems and methods for using these devices and systems for performing a wide variety of fluid operations are provided. The devices and systems of are used in performing fluid operations which require a large number of iterative, successive or parallel fluid manipulations, in a microscale, or sealed and readily automated format.

US Patent:

6444461, Sep 3, 2002

Filed:

Sep 20, 2000

Appl. No.:

09/666948

Inventors:

Michael Knapp - Redwood City CA
John Wallace Parce - Palo Alto CA
Luc J. Bousse - Menlo Park CA
Anne R. Kopf-Sill - Portola Valley CA

Assignee:

Caliper Technologies Corp. - Mountain View CA

International Classification:

C12M 100

US Classification:

4352831, 435 6, 435 71, 435 911, 435 912, 4352851, 4352871, 536 221, 536 231, 536 243, 536 2431, 536 2432, 536 2433, 436171, 436172, 436518, 204450, 204451, 204453, 204455, 204458, 422 50

Abstract:

Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components and drug screening are provided. Microfluidic devices, systems and methods for using these devices and systems for performing a wide variety of fluid operations are provided. The devices and systems of are used in performing fluid operations which require a large number of iterative, successive or parallel fluid manipulations, in a microscale, or sealed and readily automated format.

US Patent:

6447661, Sep 10, 2002

Filed:

Oct 12, 1999

Appl. No.:

09/416288

Inventors:

Andrea W. Chow - Los Altos CA
Robert S. Dubrow - San Carlos CA
J. Wallace Parce - Palo Alto CA
Steven A. Sundberg - San Francisco CA
Jeffrey A. Wolk - Half Moon Bay CA
Steven James Gallagher - Palo Alto CA
Michael R. Knapp - Redwood City CA
Anne R. Kopf-Sill - Portola Valley CA
Tammy Burd Mehta - San Jose CA

Assignee:

Caliper Technologies Corp. - Mountain View CA

International Classification:

G01N 2726

US Classification:

204453, 204604, 204601, 7386401, 7386402, 436180, 422 99, 422100

Abstract:

Methods, apparatus and systems are provided for introducing large numbers of different materials into a microfluidic analytical device rapidly, efficiently and reproducibly. In particular, improved integrated pipettor chip configurations, e. g. sippers or electropipettors, are described which are capable of sampling extremely small amounts of material for which analysis is desired, transporting material into a microfluidic analytical channel network, and performing the desired analysis on the material.

US Patent:

6482364, Nov 19, 2002

Filed:

May 3, 2001

Appl. No.:

09/848717

Inventors:

J. Wallace Parce - Palo Alto CA
Michael R. Knapp - Redwood City CA

Assignee:

Caliper Technologies Corp. - Mountain View CA

International Classification:

B01L 302

US Classification:

422100, 204451, 204453, 204604, 422 65, 436 47, 7386401, 7386411, 7386424, 7386425

Abstract:

The present invention provides for techniques for transporting materials using electrokinetic forces through the channels of a microfluidic system. The subject materials are transported in regions of high ionic concentration, next to spacer material regions of high ionic concentration, which are separated by spacer material regions of low ionic concentration. Such arrangements allow the materials to remain localized for the transport transit time to avoid mixing of the materials. Using these techniques, an electropipettor which is compatible with the microfluidic system is created so that materials can be easily introduced into the microfluidic system. The present invention also compensates for electrophoretic bias as materials are transported through the channels of the microfluidic system by splitting a channel into portions with positive and negative surface charges and a third electrode between the two portions, or by diffusion of the electrophoresing materials after transport along a channel.

US Patent:

6514399, Feb 4, 2003

Filed:

Nov 28, 2000

Appl. No.:

09/724899

Inventors:

John Wallace Parce - Palo Alto CA
Michael R. Knapp - Redwood City CA
Calvin Y. H. Chow - Portola Valley CA
Luc Bousse - Los Altos CA

Assignee:

Caliper Technologies Corp. - Mountain View CA

International Classification:

B44C 122

US Classification:

204600, 204601

Abstract:

Microfluidic devices are provided for the performance of chemical and biochemical analyses, syntheses and detection. The devices of the invention combine precise fluidic control systems with microfabricated polymeric substrates to provide accurate, low cost miniaturized analytical devices that have broad applications in the fields of chemistry, biochemistry, biotechnology, molecular biology and numerous other fields.