Michael W Laird

US Patent:

7405059, Jul 29, 2008

Filed:

Jun 7, 2006

Appl. No.:

11/447892

Inventors:

Michael W. Laird - San Ramon CA, US

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C12N 15/09
C12N 1/21

US Classification:

435 693, 4352523

Abstract:

Novel Shine-Dalgarno (ribosome binding site) sequences, vectors containing such sequences, and host cells transformed with these vectors are provided. Methods of use of such sequences, vectors, and host cells for the efficient production of proteins and fragments thereof in prokaryotic systems are also provided. In particular embodiments of the invention, compounds and methods for high efficiency production of soluble protein in prokaryotic systems are provided.

US Patent:

7906119, Mar 15, 2011

Filed:

Apr 9, 2009

Appl. No.:

12/421139

Inventors:

Craig A. Rosen - Pasadena MD, US
Michael W. Laird - San Ramon CA, US
Reiner L. Gentz - Belo Horizonte, BR

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

A61K 39/395
C07K 16/00

US Classification:

4241411, 4241501, 5303884

Abstract:

The present invention relates to antibodies and related molecules that specifically bind to protective antigen of (PA). Such antibodies have uses, for example, in the prevention and treatment of anthrax and anthrax toxin poisoning. The invention also relates to nucleic acid molecules encoding anti-PA antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same.

US Patent:

8574869, Nov 5, 2013

Filed:

Jan 19, 2012

Appl. No.:

13/354223

Inventors:

Yung-Hsiang Kao - San Mateo CA, US
Michael W. Laird - San Ramon CA, US
Melody Trexler Schmidt - San Carlos CA, US
Rita L. Wong - Redwood City CA, US
Daniel P. Hewitt - Sunnyvale CA, US

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

C12P 1/00
C12N 5/02

US Classification:

435 41, 435325

Abstract:

Provided herein are methods for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.

US Patent:

20030175208, Sep 18, 2003

Filed:

Oct 16, 2002

Appl. No.:

10/270487

Inventors:

Guo-Liang Yu - Berkeley CA, US
Reinhard Ebner - Gaithersburg MD, US
Jian Ni - Germantown MD, US
Craig Rosen - Laytonsville MD, US
Stephen Ullrich - Rockville MD, US
Michael Laird - Germantown MD, US

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

A61K051/00

US Classification:

424/001490, 424/001690

Abstract:

The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention.

US Patent:

20080004206, Jan 3, 2008

Filed:

Jul 31, 2006

Appl. No.:

11/495624

Inventors:

Craig Rosen - Laytonsville MD, US
Adam Bell - Germantown MD, US
Paul Moore - North Bethesda MD, US
Yanggu Shi - Gaithersburg MD, US
David LaFleur - Washington DC, US
Jason Bock - North Potomac MD, US
Michael Laird - San Ramon CA, US
William Haseltine - Washington DC, US
Douglas Woods - Gaithersburg MD, US
Mani Subramanian - Ellicott City MD, US

International Classification:

A61K 38/38
C07H 21/04
C07K 14/76
C12N 15/00
C12N 5/00

US Classification:

514002000, 435252100, 435255100, 435320100, 435325000, 530362000, 536023100

Abstract:

The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

US Patent:

20080194481, Aug 14, 2008

Filed:

Oct 31, 2007

Appl. No.:

11/932823

Inventors:

Craig A. Rosen - Laytonsville MD, US
Adam Bell - Germantown MD, US
Paul A. Moore - North Bethesda MD, US
Yanggu Shi - Gaithersburg MD, US
David LaFleur - Washington DC, US
Jason B. Bock - North Potomac MD, US
Michael W. Laird - San Ramon CA, US
William A. Haseltine - Washington DC, US
Douglas B. Woods - Gaithersburg MD, US
Mani Subramanian - Ellicott City MD, US

International Classification:

A61K 38/00
C07K 14/00
C12N 15/11
C12N 15/00
C12N 5/06
A61P 9/00
A61P 1/00
A61P 25/00
C12N 1/00
C12N 1/20
C12P 21/04

US Classification:

514 12, 530362, 536 234, 4353201, 435325, 4352542, 4352523, 435 697

Abstract:

The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

US Patent:

20080274503, Nov 6, 2008

Filed:

Jun 19, 2008

Appl. No.:

12/142313

Inventors:

Michael W. Laird - San Ramon CA, US

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C12P 21/04
C12N 15/11
C12N 15/00
C12N 15/63
C12N 1/20

US Classification:

435 691, 536 231, 4353201, 435471, 43525233

Abstract:

Novel Shine-Dalgarno (ribosome binding site) sequences, vectors containing such sequences, and host cells transformed with these vectors are provided. Methods of use of such sequences, vectors, and host cells for the efficient production of proteins and fragments thereof in prokaryotic systems are also provided. In particular embodiments of the invention, compounds and methods for high efficiency production of soluble protein in prokaryotic systems are provided.

US Patent:

20090053786, Feb 26, 2009

Filed:

Jul 8, 2008

Appl. No.:

12/217745

Inventors:

Yung-Hsiang Kao - San Mateo CA, US
Michael W. Laird - San Ramon CA, US
Melody Trexler Schmidt - San Carlos CA, US
Rita L. Wong - Redwood City CA, US
Daniel P. Hewitt - Sunnyvale CA, US

International Classification:

C12N 9/99
C12N 5/06

US Classification:

435184, 435375, 435358, 4352523, 43525233

Abstract:

The invention concerns methods and means for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.