Michael L Lin

US Patent:

20090203035, Aug 13, 2009

Filed:

Oct 27, 2008

Appl. No.:

12/259089

Inventors:

Nathan C. Shaner - Seaside CA, US
Michael Z. Lin - San Diego CA, US
Michael McKeown - La Jolla CA, US
Roger Y. Tsien - La Jolla CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

G01N 33/53
C07K 14/00
C07H 21/00
C12N 15/74
C12N 5/06
C12Q 1/02

US Classification:

435 71, 530350, 530402, 536 231, 4353201, 435325, 435 29

Abstract:

The present invention relates to novel fluorescent protein variants of DsRed and eqFP578. Fluorescent protein variants having increased photostability and/or having reversible photoswitching behavior, as well as polynucleotides encoding such variants are provided herein. Methods of using these novel fluorescent protein variants and methods for constructing other fluorescent protein variants having increased photostability are also provided by the present invention.

US Patent:

20100041092, Feb 18, 2010

Filed:

Sep 28, 2007

Appl. No.:

12/443411

Inventors:

Michael Z. Lin - San Diego CA, US
Roger Y. Tsien - La Jolla CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

C12Q 1/02
C07K 2/00
C12N 9/96
C07H 21/04
C12N 15/62
C12N 1/21

US Classification:

435 29, 530402, 435188, 536 234, 43525233, 536 231

Abstract:

The disclosure provides method and compositions for visualizing protein turnover. In particular, the disclosure provides methods and compositions useful for measuring the age of particular proteins or the dynamics of localized protein translation.

US Patent:

20120016320, Jan 19, 2012

Filed:

Jul 13, 2010

Appl. No.:

12/835324

Inventors:

Michael T. Lin - Sherman Oaks CA, US

International Classification:

A61M 35/00
B67D 3/00

US Classification:

604290, 222192, 222 1, 604310

Abstract:

A liquid delivery device is provided which allows for delivery of precise, small amounts of a target liquid, such as cantharadin, glycolic acid, phenol, trichloroacetic acid, or similar liquids to a specific, discrete target location, such as an area of the skin to treat conditions including, but not limited to: molluscum contagiosum, verrucous vulgaris (warts), verrucous plana (flat warts), acne scars, actinic keratosis, acrochordon (skin tags), seborrheic keratosis, dermatosis papulosa nigra, milia and lentigo (sun spots). The liquid delivery device allows for delivery of the liquid to the target area without delivering the liquid to any part of the area surrounding the precise target location, thereby eliminating unnecessary irritation such as blistering, pain, temporary or permanent tissue damage and/or scarring for the user. The liquid delivery device strongly adheres to the target liquid, eliminating spilling and the resultant danger to the user and eliminating economic waste. In one implementation, the device comprises a small, hollow tube, the material and diameter of which allow uptake and retention of a target liquid by taking advantage of capillary action and surface tension.

US Patent:

50356321, Jul 30, 1991

Filed:

May 18, 1990

Appl. No.:

7/525936

Inventors:

Edward Rudoy - Woodland Hills CA
Michael A. Lin - Anaheim CA

Assignee:

ITT Corporation - New York NY

International Classification:

H01R 13648

US Classification:

439108

Abstract:

A connector is provided of the type that has rows of contacts, which minimizes cross talk between adjacent contacts. An interceptor plate (60, FIG. 2) which is grounded or at another controlled potential, extends along each row of contacts (34), the plate lying close to the row to provide better capacitive coupling between each contact and the plate than between contacts of the same or different rows.

US Patent:

51565544, Oct 20, 1992

Filed:

Jul 22, 1991

Appl. No.:

7/733503

Inventors:

Edward Rudoy - Woodland Hills CA
Michael A. Lin - Irvine CA

Assignee:

ITT Corporation - Secaucus NJ

International Classification:

H01R 13648

US Classification:

439108

Abstract:

A connector is provided of the type that has rows of contacts, which minimizes crosstalk between adjacent contacts. An interceptor plate (60, FIG. 2) which is grounded or at another controlled potential, extends along each row of contacts (34), the plate lying close to the row to provide better capacitive coupling between each contact and the plate than between contacts of the same or different rows. The space between each contact leg and an adjacent interceptor plate, contains a dielectric whose dielectric constant varies by no more than four per cent between 1 kHz and 100 MHz. The capacitance between each contact and an adjacent interception plate is at least three times the capacitance between adjacent contacts of a row.