Michael C Lind

US Patent:

6869588, Mar 22, 2005

Filed:

May 9, 2001

Appl. No.:

09/853507

Inventors:

Richard E. Weller - Selah WA, US
Michael A. Lind - Kent WA, US
Darrell R. Fisher - Richland WA, US
Anna Gutowska - Richland WA, US
Allison A. Campbell - Kennewick WA, US

Assignee:

Battelle Memorial Institute - Richland WA

International Classification:

A61K051/00
A61M036/14

US Classification:

424 129, 424 111, 424 137

Abstract:

The present invention is a thermally reversible stimulus-sensitive gel or gelling copolymer radioisotope carrier that is a linear random copolymer of an [meth-]acrylamide derivative and a hydrophilic comonomer, wherein the linear random copolymer is in the form of a plurality of linear chains having a plurality of molecular weights greater than or equal to a minimum gelling molecular weight cutoff. Addition of a biodegradable backbone and/or a therapeutic agent imparts further utility. The method of the present invention for making a thermally reversible stimulus-sensitive gelling copolymer radionuclcide carrier has the steps of: (a) mixing a stimulus-sensitive reversible gelling copolymer with an aqueous solvent as a stimulus-sensitive reversible gelling solution; and (b) mixing a radioisotope with said stimulus-sensitive reversible gelling solution as said radioisotope carrier. The gel is enhanced by either combining it with a biodegradable backbone and/or a therapeutic agent in a gelling solution made by mixing the copolymer with an aqueous solvent.

US Patent:

20040228794, Nov 18, 2004

Filed:

Feb 19, 2004

Appl. No.:

10/784147

Inventors:

Richard Weller - Selah WA, US
Darrell Fisher - Richland WA, US
Michael Lind - Kent WA, US
Allison Campbell - Kennewick WA, US
Anna Gutowska - Richland WA, US
Craig Habeger - Chillicothe IL, US

Assignee:

Battelle Memorial Institute

International Classification:

A61K051/00
A61K033/42

US Classification:

424/001110, 424/604000

Abstract:

Disclosed herein are therapeutic agent carrier compositions that include a carrier comprised of a stimulus sensitive gel, fibrin, or combinations thereof, and a therapeutic agent such as an aqueous insoluble or confined radioisotope. Stimulus sensitive gels include thermally reversible stimulus-sensitive gels that are linear random copolymers of a [meth-]acrylamide derivative and a hydrophilic comonomer; thermogelling biodegradable polymers, which include biodegradable polymers including a linked polyethylene glycol (PEG) block and biodegradable polyester block; and enzymatically degradable polypeptide poylmers. In certain embodiments the therapeutic agent is a hydrothermally synthesized radioactive therapeutic agent, such a 90-yttrium phosphate colloid. Methods of making such carrier compositions and methods of using such carrier compositions to treat diseases such as cancer also are disclosed. For example, the carrier compositions can be injected into a tumor to treat a cancer and can be applied to the margins of a resected tumor to destroy vestigal cancer cells.

US Patent:

48254304, Apr 25, 1989

Filed:

Dec 19, 1986

Appl. No.:

6/944423

Inventors:

Joseph M. Halter - Beaverton OR
John S. Hartman - Durham OR
Michael A. Lind - Durham OR
W. Eugene Skiens - Wilsonville OR
John W. Swanson - Milwaukie OR
Jonathan R. Biles - Portland OR

Assignee:

Optical Data, Inc. - Beaverton OR

International Classification:

G11B 724

US Classification:

369275

Abstract:

An erasable optical data storage medium has an embedded servo track and a subsurface recording interface. An erasable recording structure having two dyed polymer layers is separated from the servo track by a compression layer. The servo track is formed in a hard substrate which provides mechanical support for the medium. The medium is adapted to form non-vesicular data bumps projecting into the compression layer when exposed to a write laser beam of predetermined wavelength projected through the substrate and compression layer. The embedded servo track and recording interface are sufficiently close to each to be read simultaneously in the same focal plane.

US Patent:

47808675, Oct 25, 1988

Filed:

Oct 2, 1986

Appl. No.:

6/914461

Inventors:

Michael A. Lind - Durham OR
W. Eugene Skiens - Wilsonville OR
Clyde D. Feyrer - Portland OR
Geoffrey A. Russell - Beaverton OR

Assignee:

Optical Data, Inc. - Portland OR

International Classification:

G11B 726

US Classification:

369100

Abstract:

An erasable optical data storage medium has a polymer dual recording layer including an expansion layer bonded to a retention layer, each of the layers dyed to selectively absorb light in respective narrow wavelength bands. The retention layer has a glass transition temperature substantially above the glass transition temperature of the expansion layer, and is capable of undergoing substantial viscoelastic shear deformation while below its glass transition temperature. A first laser beam heats the expansion layer causing it to expand and cause viscoelastic deformation in the retention layer while the retention layer is below its glass transition temperature. A second laser beam is used to heat the retention layer above its glass transition temperature and relax the deformation, erasing the medium.

US Patent:

62968319, Oct 2, 2001

Filed:

Apr 10, 1998

Appl. No.:

9/058712

Inventors:

Richard E. Weller - Selah WA
Michael A. Lind - Kent WA
Darrell R. Fisher - Richland WA
Anna Gutowska - Richland WA
Allison A. Campbell - Kennewick WA

Assignee:

Battelle Memorial Institute - Richland WA

International Classification:

A61K 5100
A61M 3614

US Classification:

424 129

Abstract:

The present invention is a thermally reversible stimulus-sensitive gel or gelling copolymer radioisotope carrier that is a linear random copolymer of an [meth]acrylamide derivative and a hydrophilic comonomer, wherein the linear random copolymer is in the form of a plurality of linear chains having a plurality of molecular weights greater than or equal to a minimum gelling molecular weight cutoff. Addition of a biodegradable backbone and/or a therapeutic agent imparts further utility. The method of the present invention for making a thermally reversible stimulus-sensitive gelling copolymer radionuclcide carrier has the steps of: (a) mixing a stimulus-sensitive reversible gelling copolymer with an aqueous solvent as a stimulus-sensitive reversible gelling solution; and (b) mixing a radioisotope with said stimulus-sensitive reversible gelling solution as said radioisotope carrier. The gel is enhanced by either combining it with a biodegradable backbone and/or a therapeutic agent in a gelling solution made by mixing the copolymer with an aqueous solvent.

US Patent:

49013041, Feb 13, 1990

Filed:

Oct 8, 1986

Appl. No.:

6/916609

Inventors:

Michael A. Lind - Durham OR
W. Eugene Skiens - Wilsonville OR
Clyde D. Feyrer - Portland OR
John W. Swanson - Portland OR

Assignee:

Optical Data, Inc. - Beaverton OR

International Classification:

G11B 724

US Classification:

369284

Abstract:

An erasable optical data storage medium has an integral recording layer including an expansion zone and a retention zone having different optical and thermal-mechanical properties. A uniform integral layer of dyed polymer material has the dye leached out of the surface region and a second dye diffused into the surface region to create a retention zone. The retention zone has a higher elastic modulus and glass transition temperature than the underlying expansion zone and is adapted to absorb and transmit light which is centered about a different wavelength than the expansion zone. The medium is adapted to be used with a non-ablative and non-vesicular method to create and erase optically detectable deformations in the retention zone.

US Patent:

48963143, Jan 23, 1990

Filed:

Apr 19, 1988

Appl. No.:

7/183719

Inventors:

W. Eugene Skiens - Wilsonville OR
Michael A. Lind - Durham OR
John S. Hartman - Durham OR
John W. Swanson - Portland OR
Nancy E. Iwamoto - Portland OR

Assignee:

Optical Data, Inc. - Beaverton OR

International Classification:

G11B 724

US Classification:

369284

Abstract:

An optical data storage medium includes a triple layer recording structure having an expansion layer, a retention layer and a very thin reflective layer interposed between the retention and expansion layers. The three layers are strongly bonded together so that the thermally and mechanically active expansion and retention layers can mechanically act upon each other through the intermediate reflective layer. The expansion and retention layers are dyed to selectively pass or absorb light of preselected wavelengths. The thin reflective layer is adapted to partially pass and partially reflect light of preselected wavelengths.