Michael E Lind

US Patent:

6869588, Mar 22, 2005

Filed:

May 9, 2001

Appl. No.:

09/853507

Inventors:

Richard E. Weller - Selah WA, US
Michael A. Lind - Kent WA, US
Darrell R. Fisher - Richland WA, US
Anna Gutowska - Richland WA, US
Allison A. Campbell - Kennewick WA, US

Assignee:

Battelle Memorial Institute - Richland WA

International Classification:

A61K051/00
A61M036/14

US Classification:

424 129, 424 111, 424 137

Abstract:

The present invention is a thermally reversible stimulus-sensitive gel or gelling copolymer radioisotope carrier that is a linear random copolymer of an [meth-]acrylamide derivative and a hydrophilic comonomer, wherein the linear random copolymer is in the form of a plurality of linear chains having a plurality of molecular weights greater than or equal to a minimum gelling molecular weight cutoff. Addition of a biodegradable backbone and/or a therapeutic agent imparts further utility. The method of the present invention for making a thermally reversible stimulus-sensitive gelling copolymer radionuclcide carrier has the steps of: (a) mixing a stimulus-sensitive reversible gelling copolymer with an aqueous solvent as a stimulus-sensitive reversible gelling solution; and (b) mixing a radioisotope with said stimulus-sensitive reversible gelling solution as said radioisotope carrier. The gel is enhanced by either combining it with a biodegradable backbone and/or a therapeutic agent in a gelling solution made by mixing the copolymer with an aqueous solvent.

US Patent:

6889165, May 3, 2005

Filed:

Jul 2, 2002

Appl. No.:

10/188469

Inventors:

Michael A. Lind - Kent WA, US
Kevin L. Priddy - Upper Arlington OH, US
Gary B. Morgan - Kennewick WA, US
Jeffrey W. Griffin - Kennewick WA, US
Richard W. Ridgway - Westerville OH, US
Steven L. Stein - Bothell WA, US

Assignee:

Battelle Memorial Institute - Richland WA

International Classification:

G06F013/14

US Classification:

702183, 702182, 702188, 702190

Abstract:

An intelligent microsensor module () is provided that can fuse data streams from a variety of sources and then locally determine the current state of the environment in which the intelligent microsensor is placed. The resultant state rather than raw data is communicated to the outside world when the microsensor is queried. The intelligent microsensor module () of the present invention can locally determine and execute an action to be taken based on the determined state of the environment. The module () can be readily reconfigured for multiple applications.

US Patent:

7317382, Jan 8, 2008

Filed:

Dec 13, 2004

Appl. No.:

11/011316

Inventors:

Richard M. Pratt - Richland WA, US
Jeffrey Wayne Scott - Pasco WA, US
Michael A. Hughes - Pasco WA, US
Michael A. Lind - Kent WA, US
Gary B. Morgan - Kennewick WA, US

Assignee:

Battelle Memorial Institute - Richland WA

International Classification:

B60Q 25/10

US Classification:

340428, 340447, 340442, 340445, 3405721, 3405724, 3405728, 731465, 73756

Abstract:

Remote communications devices, wireless communications systems, and wireless communications methods are described. In one aspect, a remote communications device includes communication circuitry configured to communicate wireless communication signals externally of the remote communications device, sensor circuitry configured to sense at least one condition with respect to the remote communications device, and wherein the communication circuitry is coupled with the sensor circuitry and is configured to determine a plurality of different moments in time responsive to criteria originating within the remote communications device and to communicate data indicative of the at least one sensed condition externally of the remote communications device to a reader using the wireless communication signals at the different moments in time.

US Patent:

20020131935, Sep 19, 2002

Filed:

Nov 26, 2001

Appl. No.:

09/994509

Inventors:

Darrell Fisher - Richland WA, US
Richard Weller - Selah WA, US
Michael Lind - Kent WA, US
Anna Gutowska - Richland WA, US
Allison Campbell - Kennewick WA, US

International Classification:

A61K051/00

US Classification:

424/001690

Abstract:

The present invention is a thermally reversible stimulus-sensitive gel or gelling copolymer radioisotope carrier that is a linear random copolymer of an [meth-]acrylamide derivative and a hydrophilic comonomer, wherein the linear random copolymer is in the form of a plurality of linear chains having a plurality of molecular weights greater than or equal to a minimum gelling molecular weight cutoff. Addition of a biodegradable backbone and/or a therapeutic agent imparts further utility. The method of the present invention for making a thermally reversible stimulus-sensitive gelling copolymer radionuclcide carrier has the steps of: (a) mixing a stimulus-sensitive reversible gelling copolymer with an aqueous solvent as a stimulus-sensitive reversible gelling solution; and (b) mixing a radioisotope with said stimulus-sensitive reversible gelling solution as said radioisotope carrier. The invention also comprises a second class of compounds, and a method of using the compounds, for treating diseases, and in particular, cancer. A fibrin carrier and a therapeutic agent, such as a radionuclide and/or chemotherapy agents, are mixed and applied to the tissue adjacent to a cancer removal site.

US Patent:

20040228794, Nov 18, 2004

Filed:

Feb 19, 2004

Appl. No.:

10/784147

Inventors:

Richard Weller - Selah WA, US
Darrell Fisher - Richland WA, US
Michael Lind - Kent WA, US
Allison Campbell - Kennewick WA, US
Anna Gutowska - Richland WA, US
Craig Habeger - Chillicothe IL, US

Assignee:

Battelle Memorial Institute

International Classification:

A61K051/00
A61K033/42

US Classification:

424/001110, 424/604000

Abstract:

Disclosed herein are therapeutic agent carrier compositions that include a carrier comprised of a stimulus sensitive gel, fibrin, or combinations thereof, and a therapeutic agent such as an aqueous insoluble or confined radioisotope. Stimulus sensitive gels include thermally reversible stimulus-sensitive gels that are linear random copolymers of a [meth-]acrylamide derivative and a hydrophilic comonomer; thermogelling biodegradable polymers, which include biodegradable polymers including a linked polyethylene glycol (PEG) block and biodegradable polyester block; and enzymatically degradable polypeptide poylmers. In certain embodiments the therapeutic agent is a hydrothermally synthesized radioactive therapeutic agent, such a 90-yttrium phosphate colloid. Methods of making such carrier compositions and methods of using such carrier compositions to treat diseases such as cancer also are disclosed. For example, the carrier compositions can be injected into a tumor to treat a cancer and can be applied to the margins of a resected tumor to destroy vestigal cancer cells.

US Patent:

20050242962, Nov 3, 2005

Filed:

Apr 29, 2004

Appl. No.:

10/837128

Inventors:

Michael Lind - Kent WA, US
Mario Bagaglio - Richland WA, US
Gary Morgan - Kennewick WA, US

International Classification:

G08B013/14

US Classification:

340572800, 340568200

Abstract:

A tag device includes a strap having a first end and a second end and configured to encircle a member to which the tag device is to be secured, the first end being configured to be attached to the second end of the strap, with the strap encircling a member to which the tag device is to be secured; and circuitry supported by the strap and useful for determining if the strap has been removed from the member after the first end has been attached to the second end. Other apparatus and a method of manufacturing a tag device are also provided.

US Patent:

20060025957, Feb 2, 2006

Filed:

Jul 29, 2004

Appl. No.:

10/902505

Inventors:

Michael Lind - Kent WA, US
Ronald Gilbert - Morgan Hill CA, US
Curtis Carrender - Morgan Hill CA, US

Assignee:

Battelle Memorial Institute - Richland WA

International Classification:

G01D 1/00

US Classification:

702127000

Abstract:

A system for monitoring and controlling a tool that includes a communication circuit associated with the tool and configured to store data regarding the status of the tool and to sense a condition of the tool for quality assurance and quality control. An actuator can be included for altering the operational status of the tool in response to a change in status or a change in condition.

US Patent:

62968319, Oct 2, 2001

Filed:

Apr 10, 1998

Appl. No.:

9/058712

Inventors:

Richard E. Weller - Selah WA
Michael A. Lind - Kent WA
Darrell R. Fisher - Richland WA
Anna Gutowska - Richland WA
Allison A. Campbell - Kennewick WA

Assignee:

Battelle Memorial Institute - Richland WA

International Classification:

A61K 5100
A61M 3614

US Classification:

424 129

Abstract:

The present invention is a thermally reversible stimulus-sensitive gel or gelling copolymer radioisotope carrier that is a linear random copolymer of an [meth]acrylamide derivative and a hydrophilic comonomer, wherein the linear random copolymer is in the form of a plurality of linear chains having a plurality of molecular weights greater than or equal to a minimum gelling molecular weight cutoff. Addition of a biodegradable backbone and/or a therapeutic agent imparts further utility. The method of the present invention for making a thermally reversible stimulus-sensitive gelling copolymer radionuclcide carrier has the steps of: (a) mixing a stimulus-sensitive reversible gelling copolymer with an aqueous solvent as a stimulus-sensitive reversible gelling solution; and (b) mixing a radioisotope with said stimulus-sensitive reversible gelling solution as said radioisotope carrier. The gel is enhanced by either combining it with a biodegradable backbone and/or a therapeutic agent in a gelling solution made by mixing the copolymer with an aqueous solvent.