Michael D Linden

US Patent:

20040014031, Jan 22, 2004

Filed:

Aug 7, 2002

Appl. No.:

10/212772

Inventors:

Anna Salvetti - Nantes, FR
Gilliane Chadeuf - Nantes, FR
Jacques Tessier - Nantes, FR
Philippe Moullier - Basse-Goulaine, FR
Michael Linden - New York NY, US
Peter Ward - New York NY, US
Alberto Epstein - Lyon, FR

International Classification:

C12Q001/70
C12P019/34
C12N015/85

US Classification:

435/005000, 435/455000, 435/091100

Abstract:

The present invention relates to an isolated nucleic acid sequence comprising a first DNA sequence comprising a cis-acting replication element (CARE) from an Adeno-Associated Virus (AAV), and a second DNA sequence operably linked to said CARE, wherein amplification of said isolated nucleic acid sequence occurs when said isolated nucleic acid sequence is integrated in the genome of a cell and said cell is contacted with a CARE-dependent replication unducer (CARE-DRI). It also relates to amplification methods using a CARE-dependent replication inducer (CARE-DRI) and packaging cell-lines wherein replication of the integrated rep and cap genes is inducible by a CARE-DRI.

US Patent:

20140125515, May 8, 2014

Filed:

Nov 6, 2012

Appl. No.:

13/669676

Inventors:

- Downers Grove IL, US
Michael J. Linden - Aurora IL, US

Assignee:

MAGNETROL INTERNATIONAL, INCORPORATED - Downers Grove IL

International Classification:

G01S 13/08

US Classification:

342124

Abstract:

A process measurement instrument includes a fiducial and is adapted for detection of the fiducial. The instrument includes an interface circuit comprising a drive circuit for transmitting a pulse signal at the fiducial and at a target of interest and a receive circuit receiving reflected echoes of the pulse signal and developing an analog receive signal representative of the reflected echoes. A processing circuit is operatively coupled to the interface circuit for receiving the analog receive signal and comprising a threshold detector detecting if the analog receive signal is above a select threshold value. A controller is operatively coupled to the processing circuit and responsive to leading and trailing edges of the reflected echo for the fiducial and determining an average of the leading and trailing edges to determine location of the fiducial.