Yvan Le Huerou - Boulder CO, US James F. Blake - Boulder CO, US Indrani W. Gunawardana - Boulder CO, US Peter J. Mohr - Boulder CO, US Eli M. Wallace - Boulder CO, US Bin Wang - Boulder CO, US Mark Joseph Chicarelli - Boulder CO, US Michael Lyon - Boulder CO, US
Compounds of Formula (I) are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula (I) and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
Yvan Le Huerou - Boulder CO, US James F. Blake - Boulder CO, US Indrani W. Gunwardana - Boulder CO, US Pete Mohr - Boulder CO, US Eli M. Wallace - Boulder CO, US Bin Wang - Boulder CO, US Mark Joseph Chicarelli - Boulder CO, US Michael Lyon - Boulder CO, US
Compounds of Formula I are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
- Boulder CO, US - South San Francisco CA, US Indrani W. Gunawardana - Boulder CO, US Kevin W. Hunt - Boulder CO, US Michael Lyon - Boulder CO, US Andrew T. Metcalf - Boulder CO, US Peter J. Mohr - Boulder CO, US David A. Moreno - Boulder CO, US Brad Newhouse - Boulder CO, US Li Ren - Boulder CO, US Tony P. Tang - Boulder CO, US Allen A. Thomas - Boulder CO, US Jacob Schwarz - South San Francisco CA, US Jane Schmidt - South San Francisco CA, US Lewis Gazzard - South San Francisco CA, US Huifen Chen - South San Francisco CA, US
Assignee:
Array BioPharma Inc. - Boulder CO Genentech, Inc. - South San Francisco CA
Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
- Boulder CO, US James F. Blake - Boulder CO, US Indrani W. Gunawardana - Boulder CO, US Peter J. Mohr - Boulder CO, US Eli M. Wallace - Boulder CO, US Bin Wang - Boulder CO, US Mark Joseph Chicarelli - Boulder CO, US Michael Lyon - Boulder CO, US
Assignee:
Array BioPharma Inc. - Boulder CO
International Classification:
C07D 471/04 C07D 519/00
Abstract:
Compounds of Formula I are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
- Boulder CO, US - South San Francisco CA, US Indrani W. Gunawardana - Boulder CO, US Kevin W. Hunt - Boulder CO, US Michael Lyon - Boulder CO, US Andrew T. Metcalf - Boulder CO, US Peter J. Mohr - Boulder CO, US David A. Moreno - Boulder CO, US Brad Newhouse - Boulder CO, US Li Ren - Boulder CO, US Tony P. Tang - Boulder CO, US Allen A. Thomas - Boulder CO, US Jacob Schwarz - South San Francisco CA, US Jane Schmidt - South San Francisco CA, US Lewis Gazzard - South San Francisco CA, US Huifen Chen - South San Francisco CA, US
Assignee:
Array BioPharma Inc. - Boulder Genentech, Inc. - South San Francisco CA
Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
- Boulder CO, US - South San Francisco CA, US John Gaudino - Boulder CO, US Indrani W. Gunawardana - Boulder CO, US Erik James Hicken - Boulder CO, US Kevin W. Hunt - Boulder CO, US Michael Lyon - Boulder CO, US Andrew T. Metcalf - Boulder CO, US Peter J. Mohr - Boulder CO, US David A. Moreno - Boulder CO, US Brad Newhouse - Boulder CO, US Li Ren - Boulder CO, US Jacob Schwarz - South San Francisco CA, US Huifen Chen - South San Francisco CA, US Lewis Gazzard - South San Francisco CA, US Jane Schmidt - South San Francisco CA, US Steve Do - South San Francisco CA, US
Assignee:
Array BioPharma Inc. - Boulder CO Genentech, Inc. - South San Francisco CA
Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such diseases, or associated pathological conditions are disclosed.
- Boulder CO, US James F. Blake - Boulder CO, US Indrani W. Gunawardana - Boulder CO, US Peter J. Mohr - Boulder CO, US Eli M. Wallace - Boulder CO, US Bin Wang - Boulder CO, US Mark Joseph Chicarelli - Boulder CO, US Michael Lyon - Boulder CO, US
Assignee:
ARRAY BIOPHARMA INC. - Boulder CO
International Classification:
C07D 471/04
Abstract:
Compounds of Formula I are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
- Boulder CO, US James F. Blake - Boulder CO, US Indrani W. Gunawardana - Boulder CO, US Peter J. Mohr - Boulder CO, US Eli M. Wallace - Boulder CO, US Bin Wang - Boulder CO, US Mark Joseph Chicarelli - Boulder CO, US Michael Lyon - Boulder CO, US
Compounds of Formula I are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
Dr. Lyon graduated from the Creighton University School of Medicine in 1979. He works in Stanford, CA and 1 other location and specializes in Immunology and Rheumatology. Dr. Lyon is affiliated with Stanford Hospital.