Michael A Mancini

US Patent:

20010027182, Oct 4, 2001

Filed:

May 28, 1999

Appl. No.:

09/321916

Inventors:

HUDA Y. ZOGHBI - HOUSTON TX, US
HARRY T. ORR - MINNEAPOLIS MN, US
DONALD B. DEFRANCO - PITTSBURGH PA, US
MICHAEL A. MANCINI - HOUSTON TX, US
DAVID STENOIEN - HOUSTON TX, US
CHRISTOPHER J. CUMMINGS - HOUSTON TX, US

International Classification:

A61K048/00
A01K067/00

US Classification:

514/044000, 514/002000, 800/013000

Abstract:

The present invention provides a novel method for treating neurodegenerative disease in mammals. This method involves the introduction of a therapeutic effective amount of a chaperone, a chaperone-like-compound or a compound which increases proteasome activity into the neurological system of the mammal. There is also a novel method for screening for compounds having chaperone-like activity or having activity to increase proteasome activity. The screening works in either cultured cells or animal models.

US Patent:

20110152692, Jun 23, 2011

Filed:

Dec 15, 2010

Appl. No.:

12/969396

Inventors:

Shuming Nie - Atlanta GA, US
Aaron Mohs - Atlanta GA, US
Michael Mancini - Falmouth VA, US

Assignee:

EMORY UNIVERSITY OFFICE OF TECHNOLOGY TRANSFER - Atlanta GA

International Classification:

A61B 6/00

US Classification:

600473

Abstract:

According to one aspect, a system for intraoperatively providing anatomical guidance in a diagnostic or therapeutic procedure is disclosed. In one embodiment, the system includes: a first light source configured to emit a beam of visible light; second light source configured to emit a beam of near-infrared light; a handheld probe optically coupled to the second light source; a second imaging device configured to detect visible light; a third imaging device configured to detect near-infrared light having a first predetermined wavelength; a fourth imaging device configured to detect near-infrared light having a second predetermined wavelength; a display for displaying at least one visual representation of data; and, a controller programmed to generate at least one real-time integrated visual representation of an area of interest and to display the real-time visual representation on the display for guidance during the diagnostic or therapeutic procedure.

US Patent:

20120123205, May 17, 2012

Filed:

Nov 14, 2011

Appl. No.:

13/295662

Inventors:

Shuming Nie - Atlanta GA, US
Aaron M. Mohs - Atlanta GA, US
Michael C. Mancini - Atlanta GA, US

Assignee:

EMORY UNIVERSITY - Atlanta GA

International Classification:

A61B 1/04

US Classification:

600109

Abstract:

A system and method for intra-operatively providing anatomical guidance in a diagnostic or therapeutic procedure is disclosed. In embodiments, the system includes multiple light sources configured to emit different frequencies, multiple electronic imaging devices to detect various frequencies of reflected, emitted, or scattered light. The system and method incorporate an optical probe is integral to an endoscopic device or a therapeutic laser system, optically coupled to a light source; a display for displaying at least one visual representation of data; and a controller programmed to generate at least one real-time integrated visual representation of an area of interest and to display the real-time visual representation on the display for guidance during the diagnostic or therapeutic procedure.

US Patent:

20140081133, Mar 20, 2014

Filed:

Nov 21, 2013

Appl. No.:

14/086334

Inventors:

Aaron Mohs - Atlanta GA, US
Michael Mancini - Atlanta GA, US

Assignee:

Emory University - Atlanta GA

International Classification:

A61B 19/00
A61K 49/00
A61B 5/00

US Classification:

600431

Abstract:

According to one aspect, a system for intraoperatively providing anatomical guidance in a diagnostic or therapeutic procedure is disclosed. In one embodiment, the system includes: a first light source configured to emit a beam of visible light; second light source configured to emit a beam of near-infrared light; a handheld probe optically coupled to the second light source; a second imaging device configured to detect visible light; a third imaging device configured to detect near-infrared light having a first predetermined wavelength; a fourth imaging device configured to detect near-infrared light having a second predetermined wavelength; a display for displaying at least one visual representation of data; and, a controller programmed to generate at least one real-time integrated visual representation of an area of interest and to display the real-time visual representation on the display for guidance during the diagnostic or therapeutic procedure.