Michael E Matison

US Patent:

20040167357, Aug 26, 2004

Filed:

Nov 20, 2003

Appl. No.:

10/478594

Inventors:

Sonja Mackey - Galesburg MI, US
Michael Matison - Kalamazoo MI, US
Haifeng Wu - Portage MI, US
Paul Herrinton - Portage MI, US
Michael Goble - San Diego CA, US
Moses McMillian - Portage MI, US
Vikram Kalthod - Mattawan MI, US

International Classification:

C07C311/35

US Classification:

564/086000

Abstract:

A process for preparing (S)-(-)-N-[4-[4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxy]phenyl]methanesulfonamide hemifumarate salt, which comprises reacting N-[4[(2S)-tetrahydro-5-hydroxy-2-furanyl]phenyl]methanesulfonamide (IIa) with fluoroamine (III) in the presence of triacetoxyborohydride and ethyl acetate to provide [4-[4-[ethyl(6-fluoro-6-metylheptyl)amino]-1-hydroxy]phenyl]methanesulfonamide (I) anll then converting I into the hemifumarate salt Ia. A process for preparing IIa is also claimed as well as intermediates IIa-lId.

US Patent:

20050148796, Jul 7, 2005

Filed:

Feb 28, 2005

Appl. No.:

11/068287

Inventors:

Sonja MacKey - Galesburg MI, US
Michael Matison - Kalamazoo MI, US
Haifeng Wu - Portage MI, US
Michael Goble - San Diego CA, US
Moses McMillan - Portage MI, US
Vikram Kalthod - Mattawan MI, US

International Classification:

C07C311/13

US Classification:

564097000

Abstract:

A process for preparing (S)-(−)-N-[4-[4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxylphenyl]methanesulfonamide hemifumarate salt, which comprises reacting N-[4-[(2S)-tetrahydro-5-hydroxy-2-furanyl]phenyl]methanesulfonamide(IIa) with fluoroamine (III) in the presence of triacetoxyborohydride and ethyl acetate to provide [4-[-4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxylphenyl]methanesulfonamide(I) and then converting I into the hemifumarate salt Ia. A process for preparing IIa is also claimed as well as intermediates IIa-IId.

US Patent:

20210261524, Aug 26, 2021

Filed:

Apr 28, 2021

Appl. No.:

17/243120

Inventors:

- Wesborough MA, US
Bertrand L. CHENARD - Waterford CT, US
Yuelian XU - East Haven CT, US
Roberta L. DOROW - Kalamazoo MI, US
Michael E. MATISON - Middleville MI, US
Alexander KOLCHINSKI - Winchester MA, US
Richard FORNICOLA - Littleton MA, US

International Classification:

C07D 401/06
A61K 9/00
A61P 7/02
A61M 1/36
A61L 33/00
A61L 33/04

Abstract:

The present invention provides compounds that inhibit Factor XIa or kallikrein and pharmaceutically acceptable salts thereof and compositions thereof. The present invention also provides methods of making these compounds or pharmaceutically acceptable salts thereof and compositions and methods of use thereof.

US Patent:

20210253550, Aug 19, 2021

Filed:

Apr 30, 2021

Appl. No.:

17/245691

Inventors:

- Westborough MA, US
Bertrand L. Chenard - Waterford CT, US
Yuelian Xu - East Haven CT, US
Roberta L. Dorow - Kalamazoo MI, US
Michael E. Matison - Middleville MI, US
Alexander Kolchinski - Winchester MA, US
Richard Fornicola - Littleton MA, US

International Classification:

C07D 401/06
A61P 7/02
A61L 33/04
A61L 33/00

Abstract:

Provided herein are compounds and compositions that inhibit Factor XIa or kallikrein and methods of using these compounds and compositions.