Michael J Mckeown

US Patent:

7119077, Oct 10, 2006

Filed:

Mar 15, 2000

Appl. No.:

09/526298

Inventors:

Ronald M. Evans - La Jolla CA, US
Michael B. McKeown - San Diego CA, US
Anthony E. Oro - San Diego CA, US
William A. Segraves - Ambler PA, US
Tso-Pang Yao - La Jolla CA, US

Assignee:

The Salk Institute for Biological Studies - La Jolla CA

International Classification:

C07H 21/04
A61K 48/00

US Classification:

514 44, 435 6, 435440, 435375

Abstract:

In accordance with the present invention, it has been discovered that various members of the steroid/thyroid superfamily of receptors can interact with the insect-derived ultraspiracle receptor, to form multimeric species. Accordingly, the interaction of at least one member of the steroid/thyroid superfamily of receptors with at least the dimerization domain of the ultraspiracle receptor modulates the ability of said member of the steroid/thyroid superfamily of receptors to transactivate transcription of genes maintained under hormone expression control in the presence of the cognate ligand for said member of the superfamily.