Michael T Nguyen

US Patent:

7749365, Jul 6, 2010

Filed:

Jul 26, 2006

Appl. No.:

11/460236

Inventors:

Michael Nguyen - San Jose CA, US
Luc Bousse - Los Altos CA, US

Assignee:

IntegenX, Inc. - Pleasanton CA

International Classification:

G01N 27/26
B81B 7/00

US Classification:

204453, 204604, 422 82, 436180

Abstract:

The invention herein provides improved sample injection systems and related methods to create microfluidic devices with symmetrical channel configurations that can produce relatively large sample volumes. An embodiment of the invention provides microfluidic structures with different geometries that are symmetrical from the perspective of a sample load channel and a sample waste channel, which essentially eliminates issues of time offset and other problems commonly associated with twin-T sample formation techniques. A split-injection approach and related methods of sample plug formation are therefore provided.

US Patent:

8557518, Oct 15, 2013

Filed:

Jul 28, 2010

Appl. No.:

12/845650

Inventors:

Stevan Bogdan Jovanovich - Livermore CA, US
Iuliu I. Blaga - Fremont CA, US
Michael Nguyen - San Jose CA, US
William D. Nielsen - San Jose CA, US
Mattias Vangbo - Fremont CA, US

Assignee:

IntegenX Inc. - Pleasanton CA

International Classification:

C12Q 1/68
C12P 19/34
C12M 1/36
B01L 3/00

US Classification:

435 61, 435 9121, 4352831, 4352873, 4352885, 422 681, 422502

Abstract:

The present invention discloses the integration of programmable microfluidic circuits to achieve practical applications to process biochemical and chemical reactions and to integrate these reactions. In some embodiments workflows for biochemical reactions or chemical workflows are combined. Microvalves such as programmable microfluidic circuit with Y valves and flow through valves are disclosed. In some embodiments microvalves of the present invention are used for mixing fluids, which may be part of an integrated process. These processes include mixing samples and moving reactions to an edge or reservoir for modular microfluidics, use of capture regions, and injection into analytical devices on separate devices. In some embodiments star and nested star designs, or bead capture by change of cross sectional area of a channel in a microvalve are used. Movement of samples between temperature zones are further disclosed using fixed temperature and movement of the samples by micropumps.

US Patent:

20090253181, Oct 8, 2009

Filed:

Jan 21, 2009

Appl. No.:

12/321594

Inventors:

Mattias Vangbo - Fremont CA, US
William D. Nielsen - San Jose CA, US
Lullu I. Blaga - Fremont CA, US
Seth Stern - Palo Alto CA, US
Joanne Horn - Oakland CA, US
Michael Van Nguyen - San Diego CA, US
Stevan B. Jovanovich - Livermore CA, US

Assignee:

Microchip Biotechnologies, Inc. - Dublin CA

International Classification:

C12P 19/34
B01D 17/06
B01D 57/02
B01L 3/00
G01N 33/00
C12M 1/00
G01N 1/18

US Classification:

435 911, 204601, 204660, 204453, 422102, 422 63, 422 681, 4352872, 436177

Abstract:

The invention provides for devices and methods for interfacing microchips to cartridges and pneumatic manifolds. The cartridges, microchips, and pneumatic manifolds can be integrated with downstream preparation devices, such as thermal regulating devices and separation and analysis devices.

US Patent:

20110039303, Feb 17, 2011

Filed:

Feb 5, 2008

Appl. No.:

12/526015

Inventors:

Stevan Bogdan Jovanovich - Livermore CA, US
Iuliu Ioan Blaga - Livermore CA, US
Allen Boronkay - Livermore CA, US
Joanne Horn - Livermore CA, US
Michael Van Nguyen - Livermore CA, US
William D. Nielsen - Livermore CA, US
Mattias Vangbo - Livermore CA, US

International Classification:

C12P 19/34
B01L 3/00
C07H 21/04
C07K 14/00

US Classification:

435 912, 422502, 536 231, 530395

Abstract:

The present invention discloses the integration of programmable microfluidic circuits to achieve practical applications to process biochemical and chemical reactions and to integrate these reactions. In some embodiments workflows for biochemical reactions or chemical workflows are combined. Microvalves such as programmable microfluidic circuit with Y valves and flow through valves are disclosed. In some embodiments microvalves of the present invention are used for mixing fluids, which may be part of an integrated process. These processes include mixing samples and moving reactions to an edge or reservoir for modular microfluidics, use of capture regions, and injection into analytical devices on separate devices. In some embodiments star and nested star designs, or bead capture by change of cross sectional area of a channel in a microvalve are used. Movement of samples between temperature zones are further disclosed using fixed temperature and movement of the samples by micropumps.

US Patent:

20120315635, Dec 13, 2012

Filed:

Aug 20, 2012

Appl. No.:

13/590051

Inventors:

Mattias Vangbo - Fremont CA, US
William D. Nielsen - San Jose CA, US
luliu I. Blaga - Fremont CA, US
Michael Van Nguyen - San Diego CA, US
Stevan B. Jovanovich - Livermore CA, US

Assignee:

IntegenX, Inc. - Pleasanton CA

International Classification:

G01N 27/26
G01N 21/64

US Classification:

435 611

Abstract:

The invention provides for devices and methods for interfacing microchips to cartridges and pneumatic manifolds. The cartridges, microchips, and pneumatic manifolds can be integrated with downstream preparation devices, such as thermal regulating devices and separation and analysis devices.

US Patent:

20130053255, Feb 28, 2013

Filed:

Aug 21, 2012

Appl. No.:

13/590965

Inventors:

Mattias Vangbo - Fremont CA, US
William D. Nielsen - San Jose CA, US
Iuliu I. Blaga - Fremont CA, US
Joanne Horn - Oakland CA, US
Michael Van Nguyen - San Diego CA, US
Stevan B. Jovanovich - Livermore CA, US

Assignee:

IntegenX, Inc. - Pleasanton CA

International Classification:

C40B 20/00

US Classification:

506 2

Abstract:

The invention provides for devices and methods for interfacing microchips to cartridges and pneumatic manifolds. The cartridges, microchips, and pneumatic manifolds can be integrated with downstream preparation devices, such as thermal regulating devices and separation and analysis devices.

US Patent:

20140045704, Feb 13, 2014

Filed:

May 2, 2013

Appl. No.:

13/886068

Inventors:

Stevan Bogdan Jovanovich - Livermore CA, US
luliu I. Balga - Fremont CA, US
Allen R. Boronkay - San Jose CA, US
Joanne Horn - Oakland CA, US
Michael Van Nguyen - San Diego CA, US
William D. Nielsen - San Jose CA, US
Mattias Vangbo - Fremont CA, US

Assignee:

IntegenX Inc. - Pleasanton CA

International Classification:

C12Q 1/68
B01L 7/00

US Classification:

506 2, 435 612, 435 71, 436501, 506 26, 506 40, 506 38, 4352872, 422 69, 422505

Abstract:

The present invention discloses the integration of programmable microfluidic circuits to achieve practical applications to process biochemical and chemical reactions and to integrate these reactions. In some embodiments workflows for biochemical reactions or chemical workflows are combined. Microvalves such as programmable microfluidic circuit with Y valves and flow through valves are disclosed. In some embodiments microvalves of the present invention are used for mixing fluids, which may be part of an integrated process. These processes include mixing samples and moving reactions to an edge or reservoir for modular microfluidics, use of capture regions, and injection into analytical devices on separate devices. In some embodiments star and nested star designs, or bead capture by change of cross sectional area of a channel in a microvalve are used. Movement of samples between temperature zones are further disclosed using fixed temperature and movement of the samples by micropumps.

US Patent:

55108229, Apr 23, 1996

Filed:

Aug 24, 1993

Appl. No.:

8/111028

Inventors:

Kent D. Vincent - Cupertino CA
Michael A. Nguyen - Escondido CA

Assignee:

Hewlett-Packard Company - Palo Alto CA

International Classification:

B41J 201
B41J 221

US Classification:

347102

Abstract:

A thermal ink-jet printer (10) including a paper advancing mechanism (14) and a pen traversing mechanism (18) and a pen (20) is disclosed. The pen (20) includes a nozzle plate portion (22) which includes irregularly spaced columns of nozzles (24) for staggering application of inks onto the print medium (16) such that a drying time is provided between applications of differing inks to adjacent areas. The printer (10) further includes a platen heater assembly (68) as a means of fixing and drying the ink on the print medium (16), and a vacuum fan (62) and an associated plurality of platen vacuum holes (74) as a means of holding the print medium (16) in close contact with the heater plate assembly (68), thus increasing efficiency of heat transfer. The printer (10) is characterized in that it is capable of producing, at relatively high speeds on ordinary untreated paper or other print medium, a highly defined image relatively free from the problems of color bleeding, feathering, ink coalescence, and paper cockle normally associated with ink-jet printers. The primary usage of the printer (10) is in computer generated data printout applications.