Michael M Nguyen

US Patent:

20090253181, Oct 8, 2009

Filed:

Jan 21, 2009

Appl. No.:

12/321594

Inventors:

Mattias Vangbo - Fremont CA, US
William D. Nielsen - San Jose CA, US
Lullu I. Blaga - Fremont CA, US
Seth Stern - Palo Alto CA, US
Joanne Horn - Oakland CA, US
Michael Van Nguyen - San Diego CA, US
Stevan B. Jovanovich - Livermore CA, US

Assignee:

Microchip Biotechnologies, Inc. - Dublin CA

International Classification:

C12P 19/34
B01D 17/06
B01D 57/02
B01L 3/00
G01N 33/00
C12M 1/00
G01N 1/18

US Classification:

435 911, 204601, 204660, 204453, 422102, 422 63, 422 681, 4352872, 436177

Abstract:

The invention provides for devices and methods for interfacing microchips to cartridges and pneumatic manifolds. The cartridges, microchips, and pneumatic manifolds can be integrated with downstream preparation devices, such as thermal regulating devices and separation and analysis devices.

US Patent:

20120315635, Dec 13, 2012

Filed:

Aug 20, 2012

Appl. No.:

13/590051

Inventors:

Mattias Vangbo - Fremont CA, US
William D. Nielsen - San Jose CA, US
luliu I. Blaga - Fremont CA, US
Michael Van Nguyen - San Diego CA, US
Stevan B. Jovanovich - Livermore CA, US

Assignee:

IntegenX, Inc. - Pleasanton CA

International Classification:

G01N 27/26
G01N 21/64

US Classification:

435 611

Abstract:

The invention provides for devices and methods for interfacing microchips to cartridges and pneumatic manifolds. The cartridges, microchips, and pneumatic manifolds can be integrated with downstream preparation devices, such as thermal regulating devices and separation and analysis devices.

US Patent:

20130053255, Feb 28, 2013

Filed:

Aug 21, 2012

Appl. No.:

13/590965

Inventors:

Mattias Vangbo - Fremont CA, US
William D. Nielsen - San Jose CA, US
Iuliu I. Blaga - Fremont CA, US
Joanne Horn - Oakland CA, US
Michael Van Nguyen - San Diego CA, US
Stevan B. Jovanovich - Livermore CA, US

Assignee:

IntegenX, Inc. - Pleasanton CA

International Classification:

C40B 20/00

US Classification:

506 2

Abstract:

The invention provides for devices and methods for interfacing microchips to cartridges and pneumatic manifolds. The cartridges, microchips, and pneumatic manifolds can be integrated with downstream preparation devices, such as thermal regulating devices and separation and analysis devices.

US Patent:

20140045704, Feb 13, 2014

Filed:

May 2, 2013

Appl. No.:

13/886068

Inventors:

Stevan Bogdan Jovanovich - Livermore CA, US
luliu I. Balga - Fremont CA, US
Allen R. Boronkay - San Jose CA, US
Joanne Horn - Oakland CA, US
Michael Van Nguyen - San Diego CA, US
William D. Nielsen - San Jose CA, US
Mattias Vangbo - Fremont CA, US

Assignee:

IntegenX Inc. - Pleasanton CA

International Classification:

C12Q 1/68
B01L 7/00

US Classification:

506 2, 435 612, 435 71, 436501, 506 26, 506 40, 506 38, 4352872, 422 69, 422505

Abstract:

The present invention discloses the integration of programmable microfluidic circuits to achieve practical applications to process biochemical and chemical reactions and to integrate these reactions. In some embodiments workflows for biochemical reactions or chemical workflows are combined. Microvalves such as programmable microfluidic circuit with Y valves and flow through valves are disclosed. In some embodiments microvalves of the present invention are used for mixing fluids, which may be part of an integrated process. These processes include mixing samples and moving reactions to an edge or reservoir for modular microfluidics, use of capture regions, and injection into analytical devices on separate devices. In some embodiments star and nested star designs, or bead capture by change of cross sectional area of a channel in a microvalve are used. Movement of samples between temperature zones are further disclosed using fixed temperature and movement of the samples by micropumps.

US Patent:

20220404353, Dec 22, 2022

Filed:

Nov 20, 2020

Appl. No.:

17/780227

Inventors:

- San Diego CA, US
Jim Chauvapun - San Diego CA, US
Mathias Ehrich - San Diego CA, US
Megan Monier - Corona CA, US
Michael Van Nguyen - San Diego CA, US
Dirk van den Boom - Encinitas CA, US

International Classification:

G01N 33/543
G01N 33/53
C12Q 1/6804
C12N 15/10

Abstract:

Provided are systems and methods of sample preparation and analyte detection.

US Patent:

20220380752, Dec 1, 2022

Filed:

May 25, 2022

Appl. No.:

17/824617

Inventors:

- San Diego CA, US
Mathias Ehrich - San Diego CA, US
Michael Van Nguyen - San Diego CA, US
Christopher Ellison - La Jolla CA, US
Jeffery William Domenighini - Encinitas CA, US
Dylann Duncan Ceriani - San Diego CA, US
Kristopher Scott Buchanan - Fort Collins CO, US
Michael Gordon Smith - Fort Collins CO, US

International Classification:

C12N 15/10
C12Q 1/6806

Abstract:

Provided herein are devices and methods for extracting blood plasma from ultra-low volumes of blood. In some cases, the devices and methods use positive pressure to force a blood sample through a filter or a membrane. In some cases, the devices and methods use centrifugation to force a blood sample through a filter or a membrane. The devices and methods disclosed herein are suitable for the preparation of high-quality samples containing cell-free nucleic acids.

US Patent:

20230065224, Mar 2, 2023

Filed:

Jan 28, 2021

Appl. No.:

17/795853

Inventors:

- San Diego CA, US
Kapil MAHAKALKAR - San Diego CA, US
Yi ZHANG - San Diego CA, US
Andrew Boyd MACCONNELL - San Diego CA, US
Joseph Franklin ROKICKI - San Diego CA, US
Michael VAN NGUYEN - San Diego CA, US

International Classification:

C12N 15/10
B01L 3/00

Abstract:

This application provides a bead with a covalently attached chemical compound and a covalently attached DNA barcode and methods for using such beads. The bead has many substantially identical copies of the chemical compound and many substantially identical copies of the DNA barcode. The compound consists of one or more chemical monomers, where the DNA barcode takes the form of barcode modules, where each module corresponds to and allows identification of a corresponding chemical monomer. The nucleic acid barcode can have a concatenated structure or an orthogonal structure. Provided are a method for sequencing the bead-bound nucleic acid barcode, for cleaving the compound from the bead, and for assessing biological activity of the released compound.

US Patent:

20210340609, Nov 4, 2021

Filed:

Mar 11, 2021

Appl. No.:

17/198932

Inventors:

- San Diego CA, US
Michael VAN NGUYEN - San Diego CA, US

Assignee:

Omniome, Inc. - San Diego CA

International Classification:

C12Q 1/6853
C12Q 1/6886
C12Q 1/6827
C12Q 1/686
C12Q 1/6883
C12Q 1/6872

Abstract:

A method for identifying target alleles, that includes steps of (a) forming a plurality of stabilized ternary complexes at a plurality of features on an array, wherein the stabilized ternary complexes each has a polymerase, a template nucleic acid having a target allele of a locus, a primer hybridized to the locus, and a next correct nucleotide having a cognate in the locus, wherein either (i) the primer is an allele-specific primer having a 3′ nucleotide that is a cognate nucleotide for the target allele, or (ii) the primer is a locus-specific primer and the next correct nucleotide hybridizes to the target allele; and (b) detecting stabilized ternary complexes at the features, thereby identifying the target alleles.