James Stefano - Hopkinton MA, US Clark Pan - Framingham MA, US Huawei Qiu - Framingham MA, US Michael O'Callaghan - Framingham MA, US Gloria Matthews - Framingham MA, US
Assignee:
Genzyem Corporation - Westborough MA
International Classification:
C07K 14/71 C12N 9/12
US Classification:
514 81, 530350, 530410, 4353201, 435 691, 435369
Abstract:
The invention provides compositions and methods for treating a disease or disorder associated with vascular endothelial growth factor (VEGF). Specifically, the invention relates to an oligomerized VEGF binding domain to provide VEGF antagonism, and thereby treat diseases associated thereof.
- Cambridge MA, US Clark Pan - Cambridge MA, US Huawei Qui - Cambridge MA, US Michael O'Callaghan - Cambridge MA, US Gloria Matthews - Cambridge MA, US
Assignee:
Genzyme Corporation - Cambridge MA
International Classification:
C12N 9/12 C07K 14/71
Abstract:
The invention provides compositions and methods for treating a disease or disorder associate with vascular endothelial growth factor (VEGF). Specifically, the invention relates to an oligomerized VEGF binding domain to provide VEGF antagonism, and thereby treat diseases associated thereof.
- Concord MA, US Michael O'Callaghan - Sherborn MA, US Alan H. Beggs - Needham MA, US Michael W. Lawlor - Elm Grove WI, US
International Classification:
C07K 16/18 C12N 9/16
Abstract:
The present disclosure provides methods for increasing muscle contractility in a myotubular myopathy subject following administration of fewer than 20 doses of a chimeric polypeptide that has a myotubularin protein and an internalizing moiety.
4S3 Bioscience Jan 2011 - Jan 2013
Consultant Translational Development
Sanofi Genzyme 2007 - 2010
Vice President Pathobiology and Imaging
Sanofi Genzyme 1997 - 2007
Vice President Preclinical Biology
Sanofi Genzyme Apr 1996 - Dec 1997
Director Preclinical Biology
Tufts Unversity School of Veterinary Medicine 1990 - Apr 1996
Associate Professor of Radiology
Education:
Cambridge University, United Kingdom 1974 - 1977
Doctorates, Doctor of Philosophy, Philosophy
Institute of Development Studies (Massey University) 1966 - 1969
Doctorates, Doctor of Veterinary Medicine, Medicine