Michael E O'Connell

US Patent:

6849422, Feb 1, 2005

Filed:

May 31, 2000

Appl. No.:

09/583891

Inventors:

Timothy M. Wiles - Reisterstown MD, US
David J. Turner - Owings Mills MD, US
Michael A. O'Connell - Durham NC, US
Giovanni Parmigiani - Baltimore MD, US
Merlise Clyde - Durham NC, US

Assignee:

Becton, Dickinson and Company - Franklin Lakes NJ

International Classification:

C12Q 102

US Classification:

435 29

Abstract:

A system and method for analyzing samples, such as biological samples, to accurately and effectively determine the susceptibility of the samples to antimicrobial materials, so as to determine minimum inhibitory concentration (MIC) values for the respective samples and antimicrobial materials. At each of a plurality of time intervals, the system and method directs a plurality of different analyzing light wavelengths, such as red, green and blue wavelengths, onto each of a plurality of sample wells, and detects a respective resultant light wavelength emanating from the respective sample wells for each of the analyzing light wavelengths. The system and method uses resultant light wavelengths to generate at least two growth indicator characteristic curves representing, for example, the redox state and turbidity characteristics of the sample wells. The system then uses the redox state and turbidity characteristics of sample wells containing the same antimicrobial material to determine the MIC value for that material in relation to the sample contained in those wells.

US Patent:

20040063168, Apr 1, 2004

Filed:

Oct 27, 2003

Appl. No.:

10/694122

Inventors:

Timothy Wiles - Reisterstown MD, US
David Turner - Owings Mills MD, US
Michael O'Connell - Durham NC, US
Giovanni Parmigiani - Baltimore MD, US
Merlise Clyde - Durham NC, US

International Classification:

C12Q001/02

US Classification:

435/029000

Abstract:

A system and method for analyzing samples, such as biological samples, to accurately and effectively determine the susceptibility of the samples to antimicrobial materials, so as to determine minimum inhibitory concentration (MIC) values for the respective samples and antimicrobial materials. At each of a plurality of time intervals, the system and method directs a plurality of different analyzing light wavelengths, such as red, green and blue wavelengths, onto each of a plurality of sample wells, and detects a respective resultant light wavelength emanating from the respective sample wells for each of the analyzing light wavelengths. The system and method uses resultant light wavelengths to generate at least two growth indicator characteristic curves representing, for example, the redox state and turbidity characteristics of the sample wells. The system then uses the redox state and turbidity characteristics of sample wells containing the same antimicrobial material to determine the MIC value for that material in relation to the sample contained in those wells.

US Patent:

20210205575, Jul 8, 2021

Filed:

Mar 24, 2021

Appl. No.:

17/210932

Inventors:

- Framingham MA, US
Jeffrey M. ELLENBOGEN - Towson MD, US
Adam C. FURMAN - Bolton MA, US
Jonathan ZONENSHINE - Somerville MA, US
Christopher R. PAETSCH - Cambridge MA, US
Michael Patrick O'CONNELL - Northborough MA, US

International Classification:

A61M 21/02
A61B 5/00
A61B 5/369

Abstract:

Aspects of the present disclosure provide methods, apparatuses, and systems for closed-loop sleep protection and/or sleep regulation. According to an aspect, a biosignal parameter and ambient noise are measured. The biosignal parameter is used to determined sleep condition of a subject. The sleep condition is determined based on one or more of personalized sleep data or historical sleep data collected using a subset of society. Based on the sleep condition, an arousal threshold is determined. Based on the ambient noise and the determined sleep condition, one or more actions are taken to regulate sleep and avoid sleep disruption.

US Patent:

20200086076, Mar 19, 2020

Filed:

Sep 17, 2018

Appl. No.:

16/132768

Inventors:

- Framingham MA, US
Jeffrey M. ELLENBOGEN - Towson MD, US
Adam C. FURMAN - Bolton MA, US
Jonathan ZONENSHINE - Somerville MA, US
Christopher R. PAETSCH - Cambridge MA, US
Michael Patrick O'CONNELL - Northborough MA, US

International Classification:

A61M 21/02
A61B 5/00
A61B 5/0476

Abstract:

Aspects of the present disclosure provide methods, apparatuses, and systems for closed-loop sleep protection and/or sleep regulation. According to an aspect, a biosignal parameter and ambient noise are measured. The biosignal parameter is used to determined sleep condition of a subject. The sleep condition is determined based on one or more of personalized sleep data or historical sleep data collected using a subset of society, or both. Based on the sleep condition, an arousal threshold is determined. Based on the ambient noise and the determined sleep condition, one or more actions are taken to regulate sleep and avoid sleep disruption by using sound masking or ANR