Michael C O'Hara

US Patent:

6974571, Dec 13, 2005

Filed:

Mar 28, 1996

Appl. No.:

08/913918

Inventors:

Darwin J. Prockop - Philadelphia PA, US
Ruth F. Pereira - Lansdowne PA, US
Dennis B. Leeper - Wynnewood PA, US
Michael D. O'Hara - Wyncote PA, US
Joseph Kulkosky - Philadelphia PA, US
Donald Phinney - Maple Glen PA, US
Alexey Laptev - Philadelphia PA, US

Assignee:

Thomas Jefferson University - Philadelphia PA

International Classification:

A61K048/00
C12N015/00

US Classification:

424 9321, 4353201, 435 691, 435 914

Abstract:

Methods of treating patients who are suffering from a disease, disorder or condition characterized by a bone cartilage or lung defect are disclosed. The methods comprising the step of intravenous administration of stromal cells isolated from normal syngeneic individuals or intravenous administration of stromal cells isolated from the patient subsequent to correction of the genetic defect in the isolated cells. Implant devices comprising a container that has at least one membrane surface and stromal cells isolated from bone marrow that comprise a gene construct are disclosed. The gene construct in the stromal cells comprises a nucleotide sequence that encodes a beneficial protein operably linked to regulatory elements which function in stromal cells. Methods of treating individuals with diseases, disorders or conditions which can be treated with a beneficial protein, including diseases, disorders or conditions characterized by gene defects are disclosed. The methods comprise introducing into such individuals, stromal cells that are administered in a manner that physically isolates them from the recipient's immune system and that comprise a gene construct that comprises a nucleotide sequence that encodes a beneficial protein operably linked to regulatory elements which function in stromal cells.

US Patent:

20020058039, May 16, 2002

Filed:

Apr 19, 2001

Appl. No.:

09/838093

Inventors:

Michael Coyne - Oxford PA, US
Dennis Kowalski - South Salem NY, US
David McGavin - East Lyme CT, US
Michael O'Hara - East Lyme CT, US

International Classification:

G01N033/53
G06F019/00
G01N033/48
G01N033/50

US Classification:

424/184100, 435/007100, 702/019000

Abstract:

Methods to measure the duration of adequate immune memory for animal vaccines involving a retrospective analysis utilizing veterinary vaccine administration histories and clinical histories, and markers of immunity of animals in the field to derive a vaccine's duration of adequate immune memory.

US Patent:

20030202966, Oct 30, 2003

Filed:

Apr 25, 2003

Appl. No.:

10/423232

Inventors:

Darwin Prockop - Philadelphia PA, US
Ruth Pereira - Lansdowne PA, US
Dennis Leeper - Wynnewood PA, US
Michael O'Hara - Wyncote PA, US
Joseph Kulkosky - Philadelphia PA, US
Donald Phinney - Maple Glen PA, US
Alexey Laptev - Philadelphia PA, US
Jose Caro - Gladwyn PA, US

Assignee:

Thomas Jefferson University

International Classification:

A61K045/00
C12N005/08

US Classification:

424/093700, 435/366000

Abstract:

Methods of treating patients who are suffering from a disease, disorder or condition characterized by a bone cartilage or lung defect are disclosed. The methods comprising the step of intravenous administration of stromal cells isolated from normal syngeneic individuals or intravenous administration of stromal cells isolated from the patient subsequent to correction of the genetic defect in the isolated cells. Implant devices comprising a container that has at least one membrane surface and stromal cells isolated from bone marrow that comprise a gene construct are disclosed. The gene construct in the stromal cells comprises a nucleotide sequence that encodes a beneficial protein operably linked to regulatory elements which function in stromal cells. Methods of treating individuals with diseases, disorders or conditions which can be treated with a beneficial protein, including diseases, disorders or conditions characterized by gene defects are disclosed. The methods comprise introducing into such individuals, stromal cells that are administered in a manner that physically isolates them from the recipient's immune system and that comprise a gene construct that comprises a nucleotide sequence that encodes a beneficial protein operably linked to regulatory elements which function in stromal cells.

US Patent:

20040166097, Aug 26, 2004

Filed:

Feb 26, 2004

Appl. No.:

10/787506

Inventors:

Darwin Prockop - Philadelphia PA, US
Ruth Pereira - Lansdowne PA, US
Dennis Leeper - Wynnewood PA, US
Michael O'Hara - Wyncote PA, US
Joseph Kulkosky - Philadelphia PA, US
Donald Phinney - Maple Glen PA, US
Alexey Laptev - Philadelphia PA, US
Jose Caro - Gladwyn PA, US

Assignee:

Thomas Jefferson University

International Classification:

A61K045/00
C12N005/08

US Classification:

424/093700, 435/372000

Abstract:

Methods of treating patients who are suffering from a disease, disorder or condition characterized by a bone cartilage or lung defect are disclosed. The methods comprising the step of intravenous administration of stromal cells isolated from normal syngeneic individuals or intravenous administration of stromal cells isolated from the patient subsequent to correction of the genetic defect in the isolated cells. Implant devices comprising a container that has at least one membrane surface and stromal cells isolated from bone marrow that comprise a gene construct are disclosed. The gene construct in the stromal cells comprises a nucleotide sequence that encodes a beneficial protein operably linked to regulatory elements which function in stromal cells. Methods of treating individuals with diseases, disorders or conditions which can be treated with a beneficial protein, including diseases, disorders or conditions characterized by gene defects are disclosed. The methods comprise introducing into such individuals, stromal cells that are administered in a manner that physically isolates them from the recipient's immune system and that comprise a gene construct that comprises a nucleotide sequence that encodes a beneficial protein operably linked to regulatory elements which function in stromal cells.

US Patent:

20050220815, Oct 6, 2005

Filed:

May 25, 2005

Appl. No.:

11/137154

Inventors:

Michael Coyne - Oxford PA, US
Dennis Kowalski - South Salem NY, US
David McGavin - Portage MI, US
Michael O'Hara - East Lyme CT, US

International Classification:

A61K039/12
G06F019/00
G01N033/48
G01N033/50

US Classification:

424204100, 702019000

Abstract:

Methods to measure the duration of adequate immune memory for animal vaccines involving a retrospective analysis utilizing veterinary vaccine administration histories and clinical histories, and markers of immunity of animals in the field to derive a vaccine's duration of adequate immune memory.

US Patent:

20120213752, Aug 23, 2012

Filed:

Feb 23, 2012

Appl. No.:

13/403816

Inventors:

Darwin J. Prockop - Philadelphia PA, US
Ruth F. Pereira - Lansdowne PA, US
Dennis B. Leeper - Wynnewood PA, US
Michael D. O'Hara - Wyncote PA, US
Joseph Kulkosky - Philadelphia PA, US
Donald Phinney - Maple Glen PA, US
Alexey Laptev - Philadelphia PA, US
Jose Caro - Gladwyn PA, US

International Classification:

A61K 35/12
C12N 5/10
A61P 11/00
C12N 11/00
A61P 19/04

US Classification:

424 9321, 435174, 424 937, 435325

Abstract:

Isolated stromal cells, containers comprising isolated stromal cells transfected with exogenous DNA, and methods of treating patients suffering from diseases characterized by a bone cartilage or lung defect are disclosed. The methods comprise obtaining a bone marrow sample from a donor, isolating stromal cells from the sample, and administering the isolated stromal cells to the patient.

US Patent:

20120232505, Sep 13, 2012

Filed:

Mar 7, 2012

Appl. No.:

13/413921

Inventors:

Sherif A. Eskaros - Elkton MD, US
David C. Everson - Elkton MD, US
George N. Foutrakis - Oxford PA, US
John M. Herman - Elkton MD, US
Matthew A. Johnson - Bear DE, US
Peter J. Lutz - Elkton MD, US
Michael L. O'Hara - Havre de Grace MD, US

International Classification:

A61F 5/445

US Classification:

604335, 604332

Abstract:

An device including a proximal portion adapted for placement intermediately within a hollow body cavity to capture and divert contents; the proximal portion being expandable from an initial state with an initial diameter, into an expanded state with a diameter greater than the initial diameter for engaging the proximal portion with an inner wall of the hollow body cavity; and a distal portion, connected to the proximal portion, adapted to extend through the abdominal wall or into the intestine to conduct the hollow body cavity contents out of the proximal portion.

US Patent:

57166161, Feb 10, 1998

Filed:

Mar 28, 1995

Appl. No.:

8/412066

Inventors:

Darwin J. Prockop - Philadelphia PA
Ruth F. Pereira - Lansdowne PA
Dennis B. Leeper - Wynnewood PA
Michael D. O'Hara - Wyncote PA

Assignee:

Thomas Jefferson University - Philadelphia PA

International Classification:

A61K 3528

US Classification:

424 937

Abstract:

Methods of treating patients who are suffering from a disease, disorder or condition characterized by a bone cartilage or lung defect are disclosed. The methods comprising the step of intravenous administration of stromal cells isolated from normal syngeneic individuals or intravenous administration of stromal cells isolated from the patient subsequent to correction if the genetic defect in the isolated cells. Methods of introducing genes into a recipient individual are disclosed. The methods comprise the steps of obtaining a bone marrow sample from either the recipient individual or a matched syngeneic donor, isolating adherent cells from the sample, transfecting the adherent cells that were isolated from the recipient or a matched syngeneic donor with a gene and administering the transfected adherent cells to the recipient individual intravenously. Compositions that comprise isolated stromal cells that include exogenous genes operably linked to regulatory sequences are disclosed.