Michael F O'Hara

US Patent:

6974571, Dec 13, 2005

Filed:

Mar 28, 1996

Appl. No.:

08/913918

Inventors:

Darwin J. Prockop - Philadelphia PA, US
Ruth F. Pereira - Lansdowne PA, US
Dennis B. Leeper - Wynnewood PA, US
Michael D. O'Hara - Wyncote PA, US
Joseph Kulkosky - Philadelphia PA, US
Donald Phinney - Maple Glen PA, US
Alexey Laptev - Philadelphia PA, US

Assignee:

Thomas Jefferson University - Philadelphia PA

International Classification:

A61K048/00
C12N015/00

US Classification:

424 9321, 4353201, 435 691, 435 914

Abstract:

Methods of treating patients who are suffering from a disease, disorder or condition characterized by a bone cartilage or lung defect are disclosed. The methods comprising the step of intravenous administration of stromal cells isolated from normal syngeneic individuals or intravenous administration of stromal cells isolated from the patient subsequent to correction of the genetic defect in the isolated cells. Implant devices comprising a container that has at least one membrane surface and stromal cells isolated from bone marrow that comprise a gene construct are disclosed. The gene construct in the stromal cells comprises a nucleotide sequence that encodes a beneficial protein operably linked to regulatory elements which function in stromal cells. Methods of treating individuals with diseases, disorders or conditions which can be treated with a beneficial protein, including diseases, disorders or conditions characterized by gene defects are disclosed. The methods comprise introducing into such individuals, stromal cells that are administered in a manner that physically isolates them from the recipient's immune system and that comprise a gene construct that comprises a nucleotide sequence that encodes a beneficial protein operably linked to regulatory elements which function in stromal cells.

US Patent:

7013905, Mar 21, 2006

Filed:

Apr 14, 2004

Appl. No.:

10/825354

Inventors:

Philip E. Jones - Naples FL, US
Michael J. O'Hara - Naples FL, US
Brian P. Greenawalt - Naples FL, US

Assignee:

Shaw Aero Devices, Inc. - Naples FL

International Classification:

F04F 1/00

US Classification:

137 12, 137209, 137551, 73 232, 220 883

Abstract:

The gas monitoring system may include a gas line, an oxygen sensor, a filter, a pump, a indicator, and a controller. The gas line is configured to convey gas from a space configured to receive inert gas to a location remote from the space. The oxygen sensor is fluidly coupled to the gas line at the location. The oxygen sensor is configured to determine a partial pressure of oxygen present in the gas. The filter is fluidly coupled to the gas line between the space and the location. The filter is configured to remove combustible contaminants from the gas before it reaches the oxygen sensor. The controller is electrically coupled to the oxygen sensor and to the indicator. The controller is configured to activate the indicator when the partial pressure of oxygen exceeds a predetermined level.

US Patent:

7464736, Dec 16, 2008

Filed:

Jun 24, 2005

Appl. No.:

11/166527

Inventors:

Philip E. Jones - Naples FL, US
Brian P. Greenawalt - Naples FL, US
Michael O'Hara - Naples FL, US
Cesar Gonzalez - Witchita KS, US

Assignee:

Shaw Aero Devices, Inc. - Naples FL

International Classification:

B65B 1/04

US Classification:

141350, 141348, 141349, 220 862

Abstract:

An aircraft refueling system incorporates a fuel port adapter configured to allow the use of jet fuel nozzle spout but prevent the use of avgas nozzle spout. The device has an opening that configured to receive a standard jet fuel nozzle spout. The device also includes a blocking plate that prevents a smaller, round standard avgas nozzle spout from being inserted into the opening. In addition, the device includes one or more spring-loaded flapping doors to prevent incorrect refueling while the jet fuel nozzle spout is not inserted through the flapping doors.

US Patent:

7481237, Jan 27, 2009

Filed:

Jan 6, 2006

Appl. No.:

11/327268

Inventors:

Philip E. Jones - Naples FL, US
Michael J. O'Hara - Naples FL, US
Brian P. Greenawalt - Naples FL, US

Assignee:

Parker-Hannifin Corporation - Cleveland OH

International Classification:

B67D 5/54

US Classification:

137 12, 137209, 137554, 137557, 73 232, 220 883

Abstract:

The gas monitoring system may include a gas line, an oxygen sensor, a filter, a pump, a indicator, and a controller. The gas line is configured to convey gas from a space configured to receive inert gas to a location remote from the space. The oxygen sensor is fluidly coupled to the gas line at the location. The oxygen sensor is configured to determine a partial pressure of oxygen present in the gas. The filter is fluidly coupled to the gas line between the space and the location. The filter is configured to remove combustible contaminants from the gas before it reaches the oxygen sensor. The controller is electrically coupled to the oxygen sensor and to the indicator. The controller is configured to activate the indicator when the partial pressure of oxygen exceeds a predetermined level.

US Patent:

20030202966, Oct 30, 2003

Filed:

Apr 25, 2003

Appl. No.:

10/423232

Inventors:

Darwin Prockop - Philadelphia PA, US
Ruth Pereira - Lansdowne PA, US
Dennis Leeper - Wynnewood PA, US
Michael O'Hara - Wyncote PA, US
Joseph Kulkosky - Philadelphia PA, US
Donald Phinney - Maple Glen PA, US
Alexey Laptev - Philadelphia PA, US
Jose Caro - Gladwyn PA, US

Assignee:

Thomas Jefferson University

International Classification:

A61K045/00
C12N005/08

US Classification:

424/093700, 435/366000

Abstract:

Methods of treating patients who are suffering from a disease, disorder or condition characterized by a bone cartilage or lung defect are disclosed. The methods comprising the step of intravenous administration of stromal cells isolated from normal syngeneic individuals or intravenous administration of stromal cells isolated from the patient subsequent to correction of the genetic defect in the isolated cells. Implant devices comprising a container that has at least one membrane surface and stromal cells isolated from bone marrow that comprise a gene construct are disclosed. The gene construct in the stromal cells comprises a nucleotide sequence that encodes a beneficial protein operably linked to regulatory elements which function in stromal cells. Methods of treating individuals with diseases, disorders or conditions which can be treated with a beneficial protein, including diseases, disorders or conditions characterized by gene defects are disclosed. The methods comprise introducing into such individuals, stromal cells that are administered in a manner that physically isolates them from the recipient's immune system and that comprise a gene construct that comprises a nucleotide sequence that encodes a beneficial protein operably linked to regulatory elements which function in stromal cells.

US Patent:

20040166097, Aug 26, 2004

Filed:

Feb 26, 2004

Appl. No.:

10/787506

Inventors:

Darwin Prockop - Philadelphia PA, US
Ruth Pereira - Lansdowne PA, US
Dennis Leeper - Wynnewood PA, US
Michael O'Hara - Wyncote PA, US
Joseph Kulkosky - Philadelphia PA, US
Donald Phinney - Maple Glen PA, US
Alexey Laptev - Philadelphia PA, US
Jose Caro - Gladwyn PA, US

Assignee:

Thomas Jefferson University

International Classification:

A61K045/00
C12N005/08

US Classification:

424/093700, 435/372000

Abstract:

Methods of treating patients who are suffering from a disease, disorder or condition characterized by a bone cartilage or lung defect are disclosed. The methods comprising the step of intravenous administration of stromal cells isolated from normal syngeneic individuals or intravenous administration of stromal cells isolated from the patient subsequent to correction of the genetic defect in the isolated cells. Implant devices comprising a container that has at least one membrane surface and stromal cells isolated from bone marrow that comprise a gene construct are disclosed. The gene construct in the stromal cells comprises a nucleotide sequence that encodes a beneficial protein operably linked to regulatory elements which function in stromal cells. Methods of treating individuals with diseases, disorders or conditions which can be treated with a beneficial protein, including diseases, disorders or conditions characterized by gene defects are disclosed. The methods comprise introducing into such individuals, stromal cells that are administered in a manner that physically isolates them from the recipient's immune system and that comprise a gene construct that comprises a nucleotide sequence that encodes a beneficial protein operably linked to regulatory elements which function in stromal cells.

US Patent:

20120213752, Aug 23, 2012

Filed:

Feb 23, 2012

Appl. No.:

13/403816

Inventors:

Darwin J. Prockop - Philadelphia PA, US
Ruth F. Pereira - Lansdowne PA, US
Dennis B. Leeper - Wynnewood PA, US
Michael D. O'Hara - Wyncote PA, US
Joseph Kulkosky - Philadelphia PA, US
Donald Phinney - Maple Glen PA, US
Alexey Laptev - Philadelphia PA, US
Jose Caro - Gladwyn PA, US

International Classification:

A61K 35/12
C12N 5/10
A61P 11/00
C12N 11/00
A61P 19/04

US Classification:

424 9321, 435174, 424 937, 435325

Abstract:

Isolated stromal cells, containers comprising isolated stromal cells transfected with exogenous DNA, and methods of treating patients suffering from diseases characterized by a bone cartilage or lung defect are disclosed. The methods comprise obtaining a bone marrow sample from a donor, isolating stromal cells from the sample, and administering the isolated stromal cells to the patient.

US Patent:

20130134175, May 30, 2013

Filed:

Nov 30, 2011

Appl. No.:

13/307419

Inventors:

Michael O'Hara - Naples FL, US
Michael Ostertag - Naples FL, US
John Koonce - Naples FL, US
David Steck - Estero FL, US

Assignee:

Shaw Aero Development LLC - Naples FL

International Classification:

B65D 43/22

US Classification:

220827

Abstract:

A sealing lid assembly used in connection with a service port, the sealing lid assembly including a cap; a plug extending from an underside of the cap and at least partially receivable in the service port, a first seal supported on the plug and extending radially outward therefrom to sealingly engage the service port when the cap is in a closed position; and a biasing assembly adapted to urge the cap toward the closed position.