Michael J O'Hara

US Patent:

6974571, Dec 13, 2005

Filed:

Mar 28, 1996

Appl. No.:

08/913918

Inventors:

Darwin J. Prockop - Philadelphia PA, US
Ruth F. Pereira - Lansdowne PA, US
Dennis B. Leeper - Wynnewood PA, US
Michael D. O'Hara - Wyncote PA, US
Joseph Kulkosky - Philadelphia PA, US
Donald Phinney - Maple Glen PA, US
Alexey Laptev - Philadelphia PA, US

Assignee:

Thomas Jefferson University - Philadelphia PA

International Classification:

A61K048/00
C12N015/00

US Classification:

424 9321, 4353201, 435 691, 435 914

Abstract:

Methods of treating patients who are suffering from a disease, disorder or condition characterized by a bone cartilage or lung defect are disclosed. The methods comprising the step of intravenous administration of stromal cells isolated from normal syngeneic individuals or intravenous administration of stromal cells isolated from the patient subsequent to correction of the genetic defect in the isolated cells. Implant devices comprising a container that has at least one membrane surface and stromal cells isolated from bone marrow that comprise a gene construct are disclosed. The gene construct in the stromal cells comprises a nucleotide sequence that encodes a beneficial protein operably linked to regulatory elements which function in stromal cells. Methods of treating individuals with diseases, disorders or conditions which can be treated with a beneficial protein, including diseases, disorders or conditions characterized by gene defects are disclosed. The methods comprise introducing into such individuals, stromal cells that are administered in a manner that physically isolates them from the recipient's immune system and that comprise a gene construct that comprises a nucleotide sequence that encodes a beneficial protein operably linked to regulatory elements which function in stromal cells.

US Patent:

7013905, Mar 21, 2006

Filed:

Apr 14, 2004

Appl. No.:

10/825354

Inventors:

Philip E. Jones - Naples FL, US
Michael J. O'Hara - Naples FL, US
Brian P. Greenawalt - Naples FL, US

Assignee:

Shaw Aero Devices, Inc. - Naples FL

International Classification:

F04F 1/00

US Classification:

137 12, 137209, 137551, 73 232, 220 883

Abstract:

The gas monitoring system may include a gas line, an oxygen sensor, a filter, a pump, a indicator, and a controller. The gas line is configured to convey gas from a space configured to receive inert gas to a location remote from the space. The oxygen sensor is fluidly coupled to the gas line at the location. The oxygen sensor is configured to determine a partial pressure of oxygen present in the gas. The filter is fluidly coupled to the gas line between the space and the location. The filter is configured to remove combustible contaminants from the gas before it reaches the oxygen sensor. The controller is electrically coupled to the oxygen sensor and to the indicator. The controller is configured to activate the indicator when the partial pressure of oxygen exceeds a predetermined level.

US Patent:

7464736, Dec 16, 2008

Filed:

Jun 24, 2005

Appl. No.:

11/166527

Inventors:

Philip E. Jones - Naples FL, US
Brian P. Greenawalt - Naples FL, US
Michael O'Hara - Naples FL, US
Cesar Gonzalez - Witchita KS, US

Assignee:

Shaw Aero Devices, Inc. - Naples FL

International Classification:

B65B 1/04

US Classification:

141350, 141348, 141349, 220 862

Abstract:

An aircraft refueling system incorporates a fuel port adapter configured to allow the use of jet fuel nozzle spout but prevent the use of avgas nozzle spout. The device has an opening that configured to receive a standard jet fuel nozzle spout. The device also includes a blocking plate that prevents a smaller, round standard avgas nozzle spout from being inserted into the opening. In addition, the device includes one or more spring-loaded flapping doors to prevent incorrect refueling while the jet fuel nozzle spout is not inserted through the flapping doors.

US Patent:

7481237, Jan 27, 2009

Filed:

Jan 6, 2006

Appl. No.:

11/327268

Inventors:

Philip E. Jones - Naples FL, US
Michael J. O'Hara - Naples FL, US
Brian P. Greenawalt - Naples FL, US

Assignee:

Parker-Hannifin Corporation - Cleveland OH

International Classification:

B67D 5/54

US Classification:

137 12, 137209, 137554, 137557, 73 232, 220 883

Abstract:

The gas monitoring system may include a gas line, an oxygen sensor, a filter, a pump, a indicator, and a controller. The gas line is configured to convey gas from a space configured to receive inert gas to a location remote from the space. The oxygen sensor is fluidly coupled to the gas line at the location. The oxygen sensor is configured to determine a partial pressure of oxygen present in the gas. The filter is fluidly coupled to the gas line between the space and the location. The filter is configured to remove combustible contaminants from the gas before it reaches the oxygen sensor. The controller is electrically coupled to the oxygen sensor and to the indicator. The controller is configured to activate the indicator when the partial pressure of oxygen exceeds a predetermined level.

US Patent:

20020123660, Sep 5, 2002

Filed:

Feb 21, 2001

Appl. No.:

09/790122

Inventors:

Timothy Kiorpes - Doylestown PA, US
Benjamin McDaniel - Newport Beach CA, US
Michael O'Hara - Stewartsville NJ, US

International Classification:

A61N005/00
A61M036/00

US Classification:

600/008000

Abstract:

A low attenuation radioactive seed utilizing a core having a fluted or non-circular cross section is utilized for increasing the dose rate, decreasing the dwell times and improving the clinical outcomes by increasing the dose consistency throughout the treatment zone. The fluted or non-circular cross section core would increase the surface area for the deposition of the radioactive substance thereby increasing the therapeutic efficacy of the seed. In addition, the fluted or non-circular cross section may be designed in a manner to reduce photon emission attenuation by reducing the distance an inwardly directed photon would have to travel to traverse the core.

US Patent:

20030202966, Oct 30, 2003

Filed:

Apr 25, 2003

Appl. No.:

10/423232

Inventors:

Darwin Prockop - Philadelphia PA, US
Ruth Pereira - Lansdowne PA, US
Dennis Leeper - Wynnewood PA, US
Michael O'Hara - Wyncote PA, US
Joseph Kulkosky - Philadelphia PA, US
Donald Phinney - Maple Glen PA, US
Alexey Laptev - Philadelphia PA, US
Jose Caro - Gladwyn PA, US

Assignee:

Thomas Jefferson University

International Classification:

A61K045/00
C12N005/08

US Classification:

424/093700, 435/366000

Abstract:

Methods of treating patients who are suffering from a disease, disorder or condition characterized by a bone cartilage or lung defect are disclosed. The methods comprising the step of intravenous administration of stromal cells isolated from normal syngeneic individuals or intravenous administration of stromal cells isolated from the patient subsequent to correction of the genetic defect in the isolated cells. Implant devices comprising a container that has at least one membrane surface and stromal cells isolated from bone marrow that comprise a gene construct are disclosed. The gene construct in the stromal cells comprises a nucleotide sequence that encodes a beneficial protein operably linked to regulatory elements which function in stromal cells. Methods of treating individuals with diseases, disorders or conditions which can be treated with a beneficial protein, including diseases, disorders or conditions characterized by gene defects are disclosed. The methods comprise introducing into such individuals, stromal cells that are administered in a manner that physically isolates them from the recipient's immune system and that comprise a gene construct that comprises a nucleotide sequence that encodes a beneficial protein operably linked to regulatory elements which function in stromal cells.

US Patent:

20030220534, Nov 27, 2003

Filed:

Mar 14, 2001

Appl. No.:

09/805961

Inventors:

Michael O'Hara - Stewartsville NJ, US
Benjamin McDaniel - Newport Beach CA, US

International Classification:

A61N005/00
A61M036/00

US Classification:

600/007000

Abstract:

A radioactive substance absorber is incorporated into an intravascular radiotherapy source ribbon assembly to prevent the migration of radioactive matter throughout the assembly container. The radioactive substance absorber comprises carbon in various forms and configurations. The radioactive substance absorber is positioned in proximity to the source core and absorbs radioactive materials which break free from the source core, thereby containing the radioactive material.

US Patent:

20040166097, Aug 26, 2004

Filed:

Feb 26, 2004

Appl. No.:

10/787506

Inventors:

Darwin Prockop - Philadelphia PA, US
Ruth Pereira - Lansdowne PA, US
Dennis Leeper - Wynnewood PA, US
Michael O'Hara - Wyncote PA, US
Joseph Kulkosky - Philadelphia PA, US
Donald Phinney - Maple Glen PA, US
Alexey Laptev - Philadelphia PA, US
Jose Caro - Gladwyn PA, US

Assignee:

Thomas Jefferson University

International Classification:

A61K045/00
C12N005/08

US Classification:

424/093700, 435/372000

Abstract:

Methods of treating patients who are suffering from a disease, disorder or condition characterized by a bone cartilage or lung defect are disclosed. The methods comprising the step of intravenous administration of stromal cells isolated from normal syngeneic individuals or intravenous administration of stromal cells isolated from the patient subsequent to correction of the genetic defect in the isolated cells. Implant devices comprising a container that has at least one membrane surface and stromal cells isolated from bone marrow that comprise a gene construct are disclosed. The gene construct in the stromal cells comprises a nucleotide sequence that encodes a beneficial protein operably linked to regulatory elements which function in stromal cells. Methods of treating individuals with diseases, disorders or conditions which can be treated with a beneficial protein, including diseases, disorders or conditions characterized by gene defects are disclosed. The methods comprise introducing into such individuals, stromal cells that are administered in a manner that physically isolates them from the recipient's immune system and that comprise a gene construct that comprises a nucleotide sequence that encodes a beneficial protein operably linked to regulatory elements which function in stromal cells.