Michael L Phelps

US Patent:

7329401, Feb 12, 2008

Filed:

Jan 10, 2003

Appl. No.:

10/341316

Inventors:

Tatsushi Toyokuni - Sherman Oaks CA, US
Harvey R. Herschman - Los Angeles CA, US
Michael E. Phelps - Encino CA, US
Jorge R. Barrio - Agoura Hills CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61K 51/00
A61M 36/14

US Classification:

424 181, 424 111, 424 165, 424 185, 424 189

Abstract:

This invention provides novel cyclooxygenase-2 selective agents that are particularly useful as imaging probes in non-invasive imaging techniques, such as PET and SPECT. Preferred cyclooxygenase-2 selective agents inhibit cyclooxygenase-2 activity with greater potency and specificity than conventional cyclooxygenase-2 inhibitors. Other aspects of the invention include pharmaceutical compositions including the cyclooxygenase-2 selective agents as well as methods for detecting and/or inhibiting cyclooxygenase-2. These methods are particularly useful for diagnosing and treating disorders, such as inflammation, which is characterized by elevated cyclooxygenase-2 levels.

US Patent:

58615032, Jan 19, 1999

Filed:

Apr 30, 1997

Appl. No.:

8/846424

Inventors:

Jorge R. Barrio - Agoura Hills CA
Mohammad Namavari - Los Angeles CA
Michael E. Phelps - Encino CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C07H 1916
C07D47300

US Classification:

536 2711

Abstract:

An efficient, regiocontrolled approach to the synthesis of 8-fluoropurines by direct fluorination of purines with dilute elemental fluorine, or acetyl hypofluorite, is provided. In a preferred embodiment, a purine compound is dissolved in a polar solvent and reacted with a dilute mixture of F. sub. 2 in He or other inert gas.

US Patent:

62622544, Jul 17, 2001

Filed:

Nov 25, 1998

Appl. No.:

9/199975

Inventors:

Jorge R. Barrio - Agoura Hills CA
Mohammad Namavari - Los Angeles CA
Michael E. Phelps - Encino CA

Assignee:

The Regents of Univ. of California - Oakland CA

International Classification:

C07H 19167
C07H 19173
C07D47300

US Classification:

536 2711

Abstract:

An efficient, regiocontrolled approach to the synthesis of 8-fluoropurines by direct fluorination of purines with dilute elemental fluorine, or acetyl hypofluorite, is provided. In a preferred embodiment, a purine compound is dissolved in a polar solvent and reacted with a dilute mixture of F. sub. 2 in He or other inert gas.