Michael S Pierce

US Patent:

6348616, Feb 19, 2002

Filed:

Aug 30, 2000

Appl. No.:

09/651793

Inventors:

Michael Ernest Pierce - Wilmington DE 19810
Lilian Alicia Radesca - Newark DE 19711

International Classification:

C07C27128

US Classification:

560 27, 560 30

Abstract:

The present invention describes novel methods for the synthesis of benzoxazinone compounds which are useful as human immunodeficiency virus (HIV) reverse transcriptase inhibitors. The benzoxazinone of the formula: is particularly effective in the treatment of HIV.

US Patent:

59327260, Aug 3, 1999

Filed:

Apr 11, 1997

Appl. No.:

8/838838

Inventors:

Michael Ernest Pierce - Wilmington DE
Anusuya Choudhury - Landenberg PA
Rodney Lawrence Parsons - Wilmington DE
Lilian Alicia Radesca - Newark DE

Assignee:

DuPont Pharmaceuticals Company - Wilmington DE

International Classification:

C07D26516
C07D26518

US Classification:

544 90

Abstract:

The present invention provides novel methods for the asymmetric synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1- benzoxazin-2-one of formula (VI-i) ##STR1## which is useful as a human immunodeficiency virus (HIV) reverse transcriptase inhibitor.

US Patent:

60404809, Mar 21, 2000

Filed:

Feb 11, 1999

Appl. No.:

9/248567

Inventors:

Michael E. Pierce - Wilmington DE
Cheng Y. Chen - Colonia NJ
Anusuya Choudhury - Landenberg PA
Lilian A. Radesca - Newark DE
Lushi Tan - Edison NJ
Dalian Zhao - Fanwood NJ

Assignee:

Du Pont Pharmaceuticals Company - Wilmington DE

International Classification:

C07C21500

US Classification:

564390

Abstract:

The present invention provides novel methods for the asymmetric synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1- benzoxazin-2-one of formula (VI-i) ##STR1## which is useful as a human immunodeficiency virus (HIV) reverse transcriptase inhibitor.

US Patent:

59257890, Jul 20, 1999

Filed:

Apr 6, 1998

Appl. No.:

9/055480

Inventors:

Michael E. Pierce - Wilmington DE
Cheng Y. Chen - Colonia NJ
Anusuya Choudhury - Landenberg PA
Lilian A. Radesca - Newark DE
Lushi Tan - Edison NJ
Dalian Zhao - Fanwood NJ

Assignee:

DuPont Pharmaceuticals Company - Wilmington DE

International Classification:

C07C20918

US Classification:

564399

Abstract:

The present invention provides novel methods for the asymmetric synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1- benzoxazin-2-one of formula (VI-i) ##STR1## which is useful as a human immunodeficiency virus (HIV) reverse transcriptase inhibitor.

US Patent:

48208434, Apr 11, 1989

Filed:

May 22, 1987

Appl. No.:

7/053198

Inventors:

Paul E. Aldrich - Wilmington DE
John Jonas V. Duncia - Newark DE
Michael E. Pierce - Wilmington DE

Assignee:

E. I. Du Pont de Nemours and Company - Wilmington DE

International Classification:

C07D25702
C07D40110
C07D40114
C07D40314
C07D41314

US Classification:

548252

Abstract:

Tetrazole intermediates useful to prepare antihypertensive compounds described in coassigned application U. S. Ser. No. 884,920, filed July 11, 1986, are described, these tetrazoles have the formula: ##STR1## wherein X. sup. 1 and X. sup. 2 are as described in the specification.

US Patent:

58773126, Mar 2, 1999

Filed:

Dec 31, 1996

Appl. No.:

8/777645

Inventors:

Prabhakar Kondaji Jadhav - Wilmington DE
George Clautice Emmett - Wilmington DE
Michael Ernest Pierce - Wilmington DE

Assignee:

DuPont Pharmaceuticals Company - Wilmington DE

International Classification:

C07D23936
C07D22310

US Classification:

540460

Abstract:

This invention relates to methods for preparing alkylating agents and use of the agents prepared. In particular, this invention relates to preparation methods for hydroxy halide and organooxy halide alkylating agents and their use for alkylating cyclic urea compounds.

US Patent:

60382945, Mar 14, 2000

Filed:

Dec 27, 1996

Appl. No.:

8/774231

Inventors:

Wayne D. Tran - San Jose CA
Michael E. Pierce - Orangevale CA

Assignee:

Intel Corporation - Santa Clara CA

International Classification:

H04M 1100

US Classification:

379 9307

Abstract:

A modem device is described. The modem device comprises a first connector allowing coupling to a telecommunications transmission system, a second connector allowing coupling to a computer system, and a selector capable of receiving a mode select signal and capable of automatically selecting between operational modes in response to the mode select signal. It also comprises a circuit capable of receiving signals from the telecommunications transmission system in a selected operational mode and transmitting signals to a computer system. The circuit also is capable of receiving signals from the computer system and transmitting signals to the telecommunications transmission system in the selected operational mode.

US Patent:

61472107, Nov 14, 2000

Filed:

Jun 25, 1999

Appl. No.:

9/344250

Inventors:

Michael Ernest Pierce - Wilmington DE
Lilian Alicia Radesca - Newark DE

Assignee:

Dupont Pharmaceuticals Company - Wilmington DE

International Classification:

C07D26518

US Classification:

544 92

Abstract:

The present invention describes novel methods for the synthesis of benzoxazinone compounds which are useful as human immunodeficiency virus (HIV) reverse transcriptase inhibitors. The benzoxazinone of the formula: is particularly effective in the treatment of HIV.