Michael Lorenzo Randall

US Patent:

20220323353, Oct 13, 2022

Filed:

Jun 19, 2019

Appl. No.:

17/620167

Inventors:

Elena AFONINA - Franklin Lakes NJ, US
Hiep DO - Franklin Lakes NJ, US
Emily GOEL - Franklin Lakes NJ, US
Oleg GURYEV - Franklin Lakes NJ, US
Cyal LECY - Franklin Lakes NJ, US
Majid MEHRPOUYAN - Franklin Lakes NJ, US
Michael RANDALL - Franklin Lakes NJ, US
Marybeth SHARKEY - Franklin Lakes NJ, US
Jeffrey WANG - Franklin Lakes NJ, US
- Franklin Lakes NJ, US

International Classification:

A61K 9/127
A61K 9/16
A61K 31/704
A61K 31/44

Abstract:

Drug-loaded microbead compositions including a plurality of individual microbeads of a biodegradable material, a plurality of individual vesicular agents, a first therapeutic agent, and a second therapeutic agent different from the first therapeutic agent. The vesicular agents include at least one lipid bilayer surrounding a vesicular core. The first therapeutic agent is associated with the individual vesicular agents. For example, the first therapeutic agent may be contained within the individual vesicular agents or may be associated with the individual vesicular agents by ionic or non-covalent interaction. The second therapeutic agent is different from the first therapeutic agent and contained within the individual microbeads or associated with the individual microbeads through ionic or non-covalent interaction. The second therapeutic agent may or may not be associated with the individual vesicular agents. Drug-loaded biodegradable microbead compositions include microbeads of biodegradable material and a therapeutic agent associated with N the microbeads.

US Patent:

20210052499, Feb 25, 2021

Filed:

Jun 26, 2020

Appl. No.:

16/913314

Inventors:

- Tempe AZ, US
Hiep Do - Franklin Lakes NJ, US
Emily Goel - Franklin Lakes NJ, US
Oleg Guryev - Franklin Lakes NJ, US
Cyal Lecy - Franklin Lakes NJ, US
Majid Mehrpouyan - Franklin Lakes NJ, US
Michael Randall - Franklin Lakes NJ, US
Marybeth Sharkey - Franklin Lakes NJ, US
Jeffrey Wang - Franklin Lakes NJ, US

International Classification:

A61K 9/16
A61K 31/4412
A61K 31/704
A61K 9/14
A61K 9/127
A61K 9/19

Abstract:

Drug-loaded microbead compositions include microbeads of a water-swellable polymer material and a complex of a carrier and a therapeutic agent chemically bonded to the carrier. The complex is embedded in the polymer material. Methods for preparing the drug-loaded microbead compositions and embolization compositions include loading a therapeutic agent into a water-swellable polymer material to form microbeads, then removing water from the microbeads. Additional drug-loaded microbead compositions include microbeads of a biodegradable material, vesicular agents, a first therapeutic agent associated with the vesicular agents, and a second therapeutic agent different from the first therapeutic agent. The vesicular agents include a lipid bilayer surrounding a vesicular core. The second therapeutic agent is contained within the microbeads or associated with the microbeads through ionic or non-covalent interaction and may or may not be associated with the vesicular agents. Drug-loaded biodegradable microbead compositions include microbeads of biodegradable material and a therapeutic agent.