William L. Warren - Orlando FL, US Russell Higbee - Orlando FL, US Eric Mishkin - Winter Springs FL, US Heather Fahlenkamp - Broken Arrow OK, US Michael Rivard - Natick MA, US
Assignee:
Vaxdesign Corp. - Orlando FL
International Classification:
C12N 5/06
US Classification:
435372, 435373
Abstract:
The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising a three-dimensional matrix comprising lymphoid tissue, a three-dimensional matrix comprising epithelial and/or endothelial cells, and diseased cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals.
Disease Model Incorporation Into An Artificial Immune System (Ais)
William L. Warren - Orlando FL, US Heather Fahlenkamp - Cleveland OK, US Russell G. Higbee - Orlando FL, US Eric M. Mishkin - Winter Springs FL, US Michael D. Rivard - Natick MA, US Santosh Pawar - Orlando FL, US
Assignee:
VaxDesign Corp. - Orlando FL
International Classification:
C12N 5/06
US Classification:
435372, 435373
Abstract:
The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the tissues of the immune system in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates and other materials in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interactions with the immune system, coupled with disease models to provide a more complete representation of an immune response.
Methods Of Evaluating A Test Agent In A Diseased Cell Model
William L. Warren - Orlando FL, US Heather Fahlenkamp - Cleveland OK, US Russel G. Higbee - Orlando FL, US Eric M. Mishkin - Winter Springs FL, US Michael D. Rivard - Natick MA, US Santosh Pawar - Orlando FL, US
Assignee:
Sanofi Pasteur Vaxdesign Corp. - Orlando FL
International Classification:
C12N 5/00 C12N 5/02
US Classification:
435375, 435382, 435404
Abstract:
The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the tissues of the immune system in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates and other materials in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interactions with the immune system, coupled with disease models to provide a more complete representation of an immune response.
Disease Model Incorporation Into An Artificial Immune System (Ais)
William L. Warren - Orlando FL, US Russell Higbee - Orlando FL, US Eric Mishkin - Winter Springs FL, US Heather Fahlenkamp - Cleveland OK, US Michael Rivard - Natick MA, US
Assignee:
Sanofi Pasteur Vaxdesign Corp. - Orlando FL
International Classification:
C12N 5/00 C12N 5/02
US Classification:
435375, 435382, 435404
Abstract:
The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising a three-dimensional matrix comprising lymphoid tissue, a three-dimensional matrix comprising epithelial and/or endothelial cells, and diseased cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals.
North Smithfield Junior-Senior High School North Smithfield RI 1992-1996
Community:
Eric Ferschke, Joan Jefferson, Steve Roach, Jeff Demeglio, Kelsey Montinegro, Kristina Therien, Christopher Zion, Andrea Supino, Thomas Bonin, Kerri Farrell
Michael Rivard, 48, is scheduled to be arraigned this afternoon in Quincy District Court on three charges: motor vehicle homicide by negligent operation, operating a motor vehicle after his right to drive has been revoked and impeded operation of a motor vehicle, according to Norfolk District Attorn