Michael John Rozema from 5215 41St St, Kenosha, WI 53144, age 58, Phone: 2626539541

Us Patents

Crystalline Chemotherapeutic
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US Patent:

7947843, May 24, 2011
Filed:

Oct 15, 2008
Appl. No.:

12/251879
Inventors:

Thomas B. Borchardt - Kenosha WI, US
Michael J. Rozema - Kenosha WI, US
Shailendra V. Bordawekar - Gurnee IL, US
Alexander F. Chu-Kung - Highland Park IL, US
Assignee:

Abbott Laboratories - Abbott Park IL
International Classification:

C07D 231/56
US Classification:

5483621
Abstract:

N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N′-(2-fluoro-5-methylphenyl)urea Hydrate Crystalline Form 1, ways to make it, formulations comprising it and made with it and methods of treating patients having disease using it are disclosed.

Crystalline Chemotherapeutic
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US Patent:

7960564, Jun 14, 2011
Filed:

Oct 15, 2008
Appl. No.:

12/251893
Inventors:

Thomas B. Borchardt - Kenosha WI, US
Michael J. Rozema - Kenosha WI, US
Assignee:

Abbott Laboratories - Abbott Park IL
International Classification:

C07D 231/56
US Classification:

5483621
Abstract:

N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N′-(2-fluoro-5-methylphenyl)urea Crystalline Form 1, ways to make it, formulations comprising it and made with it and methods of treating patients having disease using it are disclosed.

Synthesis Of (2S,5R)-5-Ethynyl-1-{N-(4-Methyl-1-(4-Carboxy-Pyridin-2-Yl)Piperidin-4-Yl)Glycyl}Pyrrolidine-2-Carbonitrile
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US Patent:

20080058528, Mar 6, 2008
Filed:

Jul 19, 2007
Appl. No.:

11/779936
Inventors:

Todd McDermott - Libertyville IL, US
Seble Wagaw - Evanston IL, US
Kenneth Engstrom - Mundelein IL, US
Jorge Gandarilla - North Riverside IL, US
Albert Kruger - Pleasant Prairie WI, US
Michael Rozema - Kenosha WI, US
Michael Fickes - Evanston IL, US
Steven Wittenberger - Mundelein IL, US
Lakshmi Bhagavatula - Vernon Hills IL, US
Thomas Borchardt - Kenosha WI, US
International Classification:

C07D 221/00
C07D 207/04
C07F 7/02
C07D 213/02
US Classification:

546193000, 546327000, 548400000, 548406000, 548532000, 548537000, 548540000, 548566000
Abstract:

A process for making (2S,5R)-5-ethynyl-1-{N-(4-methyl-1-(4-carboxy-pyridin-2-yl)piperidin-4-yl)glycyl}pyrrolidine-2-carbonitrile and salts thereof, and intermediates used in the process are disclosed.

Novel Substituted Octahydrocyclopenta[C]Pyrrol-4-Amines As Calcium Channel Blockers
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US Patent:

20110281870, Nov 17, 2011
Filed:

May 24, 2011
Appl. No.:

13/114829
Inventors:

Xenia B. Searle - Grayslake IL, US
Ming C. Yeung - Grayslake IL, US
Stanley DiDomenico - Richmond IL, US
Andrew O. Stewart - Libertyville IL, US
Daria Darczak - Chicago IL, US
Michael Schrimpf - Grayslake IL, US
Michael J. Rozema - Kenosha WI, US
Assignee:

ABBOTT LABORATORIES - Abbott Park IL
International Classification:

A61K 31/403
C07D 209/52
C07D 401/14
A61K 31/443
C07D 401/04
C07D 417/04
A61K 31/433
C07D 417/14
C07D 495/04
A61K 31/444
A61K 31/501
A61K 31/506
A61K 31/454
C07D 413/04
A61K 31/5377
A61P 29/00
A61P 25/00
A61P 25/08
A61P 25/24
A61P 25/22
A61P 25/18
A61P 25/28
A61P 25/16
A61P 13/02
A61P 13/10
A61P 11/06
A61P 9/00
A61P 9/10
A61P 9/12
A61P 9/06
A61P 25/30
A61P 17/00
A61P 35/00
A61P 3/10
A61P 15/08
A61P 15/00
C07D 403/12
US Classification:

5142352, 548467, 548515, 514414, 514412, 5462767, 514339, 548136, 514363, 5462687, 514338, 5462734, 546114, 514301, 544238, 51425206, 544335, 514256, 5462774, 546200, 514323, 544143
Abstract:

The present application relates to calcium channel inhibitors containing compounds of formula (I)wherein L, L, R, R, and Rare as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

Isomerisation Process
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US Patent:

60254874, Feb 15, 2000
Filed:

Mar 27, 1998
Appl. No.:

9/000211
Inventors:

Stephen Hanessian - Centreville, CA
Michael John Rozema - North Chicago IL
Assignee:

Glaxo Wellcome SpA - Verona
International Classification:

C07D20508
US Classification:

540200
Abstract:

A process for the preparation of a compound (I) ##STR1## wherein R is a hydroxyl protecting group which comprises isomerising a compound of formula (I) wherein R is a hydroxyl protecting group by reacting the compound of formula (I) with a sterically hindered organic base in the presence of a Lewis acid and a compound of forumula (III) ##STR2## wherein R. sub. 1 and R. sub. 2 each independently represent cyano, COR. sub. 5 or COR. sub. 2 R. sub. 6 or R. sub. 1 and R. sub. 2 together with the carbon atom to which they are attached from a C. dbd. O group; R. sub. 5 represents alkyl, cycloalkyl, amino, alkylamino, dialkyl amino or optionally substituted phenyl or phenylalkyl group; R. sub. 6 represents alkyl, cycloalkyl or optionally substituted phenyl or phenylalkyl group; R. sub. 3 and R. sub. 4 represent each independently hydrogen, alkyl, alkoxy or optionally substituted phenyl group.

Processes For The Preparation Of (3S,4R)-3-Ethyl-4-(3H-Imidazo[1,2-A]Pyrrolo[2,3-E]-Pyrazin-8-Yl)-N-(2,2,2-Trifluoroethyl)Pyrrolidine-1-Carboxamide And Solid State Forms Thereof
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US Patent:

20220281882, Sep 8, 2022
Filed:

Feb 9, 2022
Appl. No.:

17/668249
Inventors:

- North Chicago IL, US
Jayanthy Jayanth - Buffalo Grove IL, US
Mathew Mulhern - Lake Villa IL, US
Fredrik Lars Nordstrom - Ridgefield CT, US
Ahmed A. Othman - Libertyville IL, US
Michael J. Rozema - Kenosha WI, US
Lakshmi Bhagavatula - Vernon Hills IL, US
Patrick J. Marroum - Springfield IL, US
Peter T. Mayer - Libertyville IL, US
Ahmad Y. Sheikh - Lake Forest IL, US
Thomas B. Borchardt - Kenosha WI, US
Ben Klünder - Ludwigshafen, DE
Aileen L. Pangan - LaGrange IL, US
Jaclyn Kay Anderson - Gurnee IL, US
In-Ho Song - Vernon Hills IL, US
Jose Jeffrey V. Enejosa - Chicago IL, US
International Classification:

C07D 487/14
A61K 9/00
A61K 31/4985
A61K 47/12
A61K 47/38
Abstract:

The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-α]pyrrolo[2.3-]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis), kits, methods of synthesis, and products-by-process.

Processes For The Preparation Of (3S,4R)-3-Ethyl-4-(3H-Imidazo[1,2-A]Pyrrolo[2,3-E]-Pyrazin-8-Yl)-N-(2,2,2-Trifluoroethyl)Pyrrolidine-1-Carboxamide And Solid State Forms Thereof
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US Patent:

20220267342, Aug 25, 2022
Filed:

May 2, 2022
Appl. No.:

17/735061
Inventors:

- North Chicago IL, US
Jayanthy Jayanth - Buffalo Grove IL, US
Mathew Mulhern - Lake Villa IL, US
Fredrik Lars Nordstrom - Ridgefield CT, US
Ahmed A. Othman - Libertyville IL, US
Michael J. Rozema - Kenosha WI, US
Lakshmi Bhagavatula - Vernon Hills IL, US
Patrick J. Marroum - Springfield IL, US
Peter T. Mayer - Libertyville IL, US
Ahmad Y. Sheikh - Lake Forest IL, US
Thomas B. Borchardt - Kenosha WI, US
Ben Klünder - Ludwigshafen, DE
International Classification:

C07D 487/14
A61K 47/12
A61K 31/4985
A61K 9/00
A61K 47/38
Abstract:

The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis and various spondyloarthritic conditions, including types of axial spondyloarthritis (axSpA)), kits, methods of synthesis, and products-by-process. In various aspects, provided are methods for treating active non-radiographic axSpA (nr-axSpA) and methods for treating active ankylosing spondylitis (AS).

Processes For The Preparation Of (3S,4R)-3-Ethyl-4-(3H-Imidazo[1,2-A]Pyrrolo[2,3-E]-Pyrazin-8-Yl)-N-(2,2,2-Trifluoroethyl)Pyrrolidine-1-Carboxamide And Solid State Forms Thereof
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US Patent:

20220251101, Aug 11, 2022
Filed:

Apr 11, 2022
Appl. No.:

17/717486
Inventors:

- North Chicago IL, US
Jayanthy JAYANTH - Buffalo Grove IL, US
Mathew MULHERN - Lake Villa IL, US
Fredrik Lars NORDSTROM - Ridgefield CT, US
Ahmed A. OTHMAN - Libertyville IL, US
Michael J. ROZEMA - Kenosha WI, US
Lakshmi BHAGAVATULA - Vernon Hills IL, US
Patrick J. MARROUM - Springfield IL, US
Peter T. MAYER - Libertyville IL, US
Ahmad Y. SHEIKH - Lake Forest IL, US
Thomas B. BORCHARDT - Kenosha WI, US
Ben KLÜNDER - Ludwigshafen, DE
International Classification:

C07D 487/14
A61K 9/00
A61K 31/4985
A61K 47/12
A61K 47/38
Abstract:

The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis and various spondyloarthritic conditions, including types of axial spondyloarthritis (axSpA)), kits, methods of synthesis, and products-by-process. In various aspects, provided are methods for treating active non-radiographic axSpA (nr-axSpA) and methods for treating active ankylosing spondylitis (AS).