Michael John Ruggieri

US Patent:

20050096562, May 5, 2005

Filed:

Nov 5, 2003

Appl. No.:

10/702265

Inventors:

Michael Ruggieri - King of Prussia PA, US
Michel Pontari - Lafayette Hill PA, US
Bujjibabu Godavarthi - Philadelphia PA, US

International Classification:

A61B005/00

US Classification:

600561000, 128903000

Abstract:

Systems, apparatus, and methods are disclosed for telemetrically monitoring parameters within a body of an animal such as a within a urinary bladder of a human. The system includes an implantable device configured for insertion within the body and an external device for use external to the body. The implantable device senses and stores one or more bodily parameters and transmits the stored bodily parameters for receipt by the external device responsive to receipt of a parameter transfer signal. The external device communicates with the implantable device, generates the parameter transfer signal, and receives the bodily parameters transmitted by the implantable device.

US Patent:

20110294698, Dec 1, 2011

Filed:

Jun 21, 2011

Appl. No.:

13/165133

Inventors:

Michael R. Ruggieri - King of Prussia PA, US
Larry S. Miller - Bala Cynwyd PA, US
Alan S. Braverman - Exton PA, US
Anil K. Vegesna - Philadelphia PA, US
Mary F. Barbe - Dresher PA, US

Assignee:

Temple University of the Commonwealth System of Higher Education - Philadelphia PA

International Classification:

C40B 30/06
G01N 33/566
G01N 33/74
C12Q 1/02

US Classification:

506 10, 435 29, 435 721

Abstract:

Methods for identifying modulators of gastroesophageal smooth muscle relaxation include isolating various types of smooth muscle fibers from the stomach or esophagus and inducing the fibers to contract. The isolated and contracted fibers are used to screen test compounds for the compound's capacity to modulate relaxation of the smooth muscle fibers. In addition, newly identified unique nicotinic acetylcholine receptors are expressed in a cell, and used to screen test compounds for the compound's capacity to modulate the biological activity of the receptors.