Michael A Samuels

US Patent:

20100022414, Jan 28, 2010

Filed:

Jul 17, 2009

Appl. No.:

12/504764

Inventors:

Darren Link - Lexington MA, US
Brian Hutchison - Arlington MA, US
Michael Samuels - Windham NH, US
Michael Weiner - Guilford CT, US

Assignee:

Raindance Technologies, Inc. - Lexington MA

International Classification:

C40B 40/10
C40B 40/04
C40B 50/08

US Classification:

506 18, 506 15, 506 27

Abstract:

The present invention generally relates to droplet libraries and to systems and methods for the formation of libraries of droplets. The present invention also relates to methods utilizing these droplet libraries in various biological, chemical, or diagnostic assays.

US Patent:

20120264646, Oct 18, 2012

Filed:

Jun 1, 2012

Appl. No.:

13/487030

Inventors:

Darren R. Link - Lexington MA, US
Michael L. Samuels - Windham NH, US

Assignee:

Raindance Technologies, Inc. - Lexington MA

International Classification:

C40B 30/08
G01N 33/566
G01N 21/00
C12M 1/40
G01N 33/573
G01N 21/64

US Classification:

506 11, 435 74, 435 23, 435 61, 435 18, 4352887, 435 794

Abstract:

The invention generally relates to methods for quantifying an amount of enzyme molecules. Systems and methods of the invention are provided for measuring an amount of target by forming a plurality of fluid partitions, a subset of which include the target, performing an enzyme-catalyzed reaction in the subset, and detecting the number of partitions in the subset. The amount of target can be determined based on the detected number.

US Patent:

20130210659, Aug 15, 2013

Filed:

Feb 11, 2013

Appl. No.:

13/764459

Inventors:

Andrew Watson - Bedford MA, US
Darren Roy Link - Lexington MA, US
Jeffrey Charles Olson - Chelmsford MA, US
Michael Samuels - Windham NH, US

International Classification:

C12N 15/10
C12Q 1/68

US Classification:

506 9

Abstract:

The invention generally relates to method for screening for a condition in a subject. In certain embodiments, methods of the invention involve obtaining a pool of nucleic acids from a sample, incubating the nucleic acids with first and second sets of binders, in which the first set binds uniquely to different regions of a target nucleic acid in the pool, the second set binds uniquely to different regions of a reference nucleic acid in the pool, and the first and second sets include different detectable labels, removing unbound binders, detecting the labels, and screening for a condition based upon results of the detecting step.

US Patent:

20180353913, Dec 13, 2018

Filed:

Aug 20, 2018

Appl. No.:

16/105042

Inventors:

- Cambridge MA, US
Brian Hutchison - Arlington MA, US
Michael L. Samuels - Windham NH, US
Michael Weiner - Guilford CT, US

International Classification:

B01F 3/08
G01N 33/50
C40B 50/08
C40B 40/04

Abstract:

The present invention generally relates to droplet libraries and to systems and methods for the formation of libraries of droplets. The present invention also relates to methods utilizing these droplet libraries in various biological, chemical, or diagnostic assays.

US Patent:

20180032153, Feb 1, 2018

Filed:

Jul 26, 2017

Appl. No.:

15/660100

Inventors:

Michael Joshua Samuels - Weston MA, US

International Classification:

G06F 3/0346

Abstract:

A first icosidodecahedron includes a motion sensor that provides data indicative of motion of the first icosidodecahedron. The accelerometer provides this data to a microprocessor, which then determines a state vector corresponding to the data. The microprocessor provides the state data to a communication interface that is configured to communicate the state vector to a control computer, which then selects corresponding output to be provided to either a speaker or a display or both.

US Patent:

20170028365, Feb 2, 2017

Filed:

Oct 11, 2016

Appl. No.:

15/290378

Inventors:

- Billerica MA, US
Brian Hutchison - Arlington MA, US
Michael Samuels - Windham NH, US
Michael Weiner - Guilford CT, US

International Classification:

B01F 3/08
B01F 13/00

Abstract:

The present invention generally relates to droplet libraries and to systems and methods for the formation of libraries of droplets. The present invention also relates to methods utilizing these droplet libraries in various biological, chemical, or diagnostic assays.

US Patent:

20150126400, May 7, 2015

Filed:

Jan 14, 2015

Appl. No.:

14/596949

Inventors:

- Billerica MA, US
Darren R. Link - Lexington MA, US
Jeffrey Charles Olson - Chelmsford MA, US
Michael Samuels - Windham NH, US

International Classification:

C12N 15/10
C12Q 1/68

US Classification:

506 9

Abstract:

The invention generally relates to method for screening for a condition in a subject. In certain embodiments, methods of the invention involve obtaining a pool of nucleic acids from a sample, incubating the nucleic acids with first and second sets of binders, in which the first set binds uniquely to different regions of a target nucleic acid in the pool, the second set binds uniquely to different regions of a reference nucleic acid in the pool, and the first and second sets include different detectable labels, removing unbound binders, detecting the labels, and screening for a condition based upon results of the detecting step.

US Patent:

20140295421, Oct 2, 2014

Filed:

Jun 1, 2012

Appl. No.:

14/122766

Inventors:

Darren Link - Lexington MA, US
Michael L. Samuels - Windham NH, US

Assignee:

RAINDANCE TECHNOLOGIES, INC. - Lexington MA

International Classification:

C12Q 1/25

US Classification:

435 611, 435 23, 4352887, 4352872

Abstract:

The invention generally relates to methods for quantifying an amount of enzyme molecules. Systems and methods of the invention are provided for measuring an amount of target by forming a plurality of fluid partitions, a subset of which include the target, performing an enzyme-catalyzed reaction in the subset, and detecting the number of partitions in the subset. The amount of target can be determined based on the detected number.