Michael M Santos

US Patent:

20090192079, Jul 30, 2009

Filed:

Oct 9, 2008

Appl. No.:

12/248307

Inventors:

Michael Santos - Cambridge MA, US
Michael Philbrook - Boston MA, US
Michael A. DiMicco - Brookline MA, US
Robert J. Miller - East Bridgewater MA, US

Assignee:

Genzyme Corporation - Cambridge MA

International Classification:

A61K 38/16
A61P 17/02

US Classification:

514 8

Abstract:

The present invention relates to a heparin-derivatized collagen matrix comprising a fragment of heparin covalently linked to a collagen scaffold, wherein the fragment of heparin has molecular weight of less than about 15 kDa, and at least one heparin-binding growth factor (HBGF) or heparin-binding adeno-associated virus (HB-AAV) or a combination thereof and methods for promoting bone growth, bone repair, cartilage repair, bone development, neo-angiogensis, wound healing, tissue engraftment and muscle tissue regeneration and/or tissue augmentation comprising administering a heparin-derivatized collagen matrix that includes at least one heparin-binding growth factor or heparin-binding adeno-associated virus or a combination thereof.

US Patent:

20220331400, Oct 20, 2022

Filed:

Apr 14, 2022

Appl. No.:

17/720601

Inventors:

- Mansfield MA, US
Michael Santos - Mansfield MA, US

International Classification:

A61K 38/17
A61K 9/08
A61K 9/00

Abstract:

The present disclosure includes formulations of processed silk and related methods of preparation and use in a variety of applications.

US Patent:

20190038756, Feb 7, 2019

Filed:

Feb 10, 2017

Appl. No.:

16/077078

Inventors:

- Cambridge MA, US
Michael Santos - Cambridge MA, US
Andrew Bellinger - Wellesley MA, US

International Classification:

A61K 47/42
A61K 9/06
A61K 47/10
A61K 31/415
A61P 29/00

Abstract:

Provided herein are compositions that include a benzenesulfonamide-containing NSAID, silk fibroin, and a gelling agent. Also provided are kits that include any of these compositions, and methods of making any of these compositions. Also provided are methods of treating an inflammatory and/or pain condition in a subject and methods of reducing inflammation, pain, or fever in a subject in need thereof, that include administering a therapeutically effective amount of any of these compositions.