Michael J Simons

US Patent:

7724704, May 25, 2010

Filed:

Jul 17, 2006

Appl. No.:

11/487722

Inventors:

Michael Terry Simons - Pleasanton CA, US
David Bradburn Aragon - Berkeley CA, US

Assignee:

Beiden Inc. - St. Louis MO

International Classification:

H04L 1/00
H04W 4/00

US Classification:

370329, 370338

Abstract:

This specification describes a system and method that can offer, among other advantages, a technique for resource assignment that involves obtaining a group of resources, repeatedly selecting a resource from the group of resources until a resource that is available is selected, and associating a client or process with that resource. An example of a method according to the technique includes obtaining a group of VLANs for assignment to a client based on client identity, selecting a first choice from the group of VLANs, selecting a next choice from the group of VLANs if the first choice is unavailable, and connecting the client to the selected VLAN. The client identity may include, by way of example but not limitation, a MAC address, an SSID, or some other known or convenient way to identify the client. A system constructed according to the technique may include, by way of example but not limitation, memory, a resource group name decoder, a value calculator, an index calculator, and a selector. The memory may include, for example, a resource name buffer, an identity buffer, a result buffer, a resource count buffer, a resource name array, and a selected resource buffer.

US Patent:

20100092958, Apr 15, 2010

Filed:

Oct 5, 2007

Appl. No.:

12/444423

Inventors:

Michael Simons - Hamden CT, US
Thomas W. Chittenden - Boston MA, US

International Classification:

C12Q 1/68
C12Q 1/00

US Classification:

435 6, 435 4

Abstract:

The present invention relates to a method for determining collateral artery development in a human subject with coronary artery disease based upon the levels of expression of markers associated with collateral artery development in coronary artery disease.

US Patent:

20120104741, May 3, 2012

Filed:

Oct 29, 2010

Appl. No.:

12/916351

Inventors:

Peter Hollister Brewster - Hillsborough CA, US
Michael Simons - Hillsborough CA, US

International Classification:

B42D 15/00
B65D 51/24

US Classification:

283 67, 220212

Abstract:

An apparatus can include a generally planar portion approximately in a plane. The apparatus can also include a lip portion extending in a direction generally orthogonal to the plane. The generally planar portion is joined to the lip portion at a circumferential edge of the generally planar portion to form a cover for a beverage container. The lip portion comprises a sterilizing agent configured to sterilize a rim portion of the beverage container. Likewise, a method can include providing contact information on a disposable cover adapted to cover a beverage container. The contact information is not provided by the manufacturer of the beverage or beverage container. The method can also include receiving contact from a user of the disposable cover. The method can further include coordinating the delivery of a service to the user of the disposable cover responsive to the contact received from the user.

US Patent:

20220233573, Jul 28, 2022

Filed:

Jul 14, 2020

Appl. No.:

17/626581

Inventors:

- New Haven CT, US
Michael SIMONS - New Haven CT, US

International Classification:

A61K 31/713
A61K 31/436
A61K 45/06
A61P 9/00
A61P 9/02
C12N 15/113

Abstract:

In various aspects and embodiments, the invention provides methods of treating pulmonary arterial hypertension by inhibiting the endothelial to mesenchymal transition. The invention provides a method of treating pulmonary arterial hypertension (PAH) in a subject, the method comprising administering to the subject an agent that modulates the activity or level of let-7 mlRNA in an endothelial cell in the subject, thereby treating PAH in the subject. In another aspect, the invention provide a method of treating PAH in a subject, the method comprising administering to the subject an agent that decreases the activity or level of an endothelial TGFβ signaling polypeptide or a TGFβ peptide receptor, thereby treating PAH in the subject.

US Patent:

20200229624, Jul 23, 2020

Filed:

Jan 18, 2019

Appl. No.:

16/252062

Inventors:

Peter Hollister BREWSTER - Hillsborough CA, US
Michael SIMONS - Hillsborough CA, US

International Classification:

A47G 19/22
B65D 51/24
A61B 5/145
A61B 5/08
A61B 5/00
A61B 5/1172
B01F 11/00
B01F 3/04

Abstract:

An apparatus can include a generally planar portion approximately in a plane. The apparatus can also include a lip portion extending in a direction generally orthogonal to the plane. The generally planar portion is joined to the lip portion at a circumferential edge of the generally planar portion to form a cover for a beverage container. Likewise, a method can include providing contact information on a disposable cover adapted to cover a beverage container. The contact information is not necessarily provided by the manufacturer of the beverage or beverage container. The method can also include receiving contact from a user of the disposable cover. The method can further include coordinating the delivery of a service to the user of the disposable cover responsive to the contact received from the user.

US Patent:

20160310645, Oct 27, 2016

Filed:

Jul 5, 2016

Appl. No.:

15/202374

Inventors:

- New Haven CT, US
Tarek Fahmy - New Haven CT, US
Michael Simons - Hamden CT, US
Pei-Yu Chen - East Haven CT, US
Daniel Rowe Duncan - Boston MA, US
Joseph Patterson - New Haven CT, US

International Classification:

A61L 31/16
A61L 27/58
A61L 31/14
A61L 27/50
A61L 27/26
A61L 31/04
A61L 27/18
A61L 31/06
A61L 27/54
A61L 27/56

Abstract:

Methods for treating or preventing neointima stenosis are disclosed. The methods generally involve the use of a TGFβ inhibitor, a SMAD2 inhibitor, an FGF Receptor agonist, a Let-7 agonist, or a combination thereof, to inhibit endothelial-to-mesenchymal transition (Endo-MT) of vascular endothelial cells into smooth muscle cells (SMC) at sites of endothelial damage. The disclosed methods can therefore be used to prevent or inhibit neointimal stenosis or restenosis, e.g., after angioplasty, vascular graft, or stent. Also disclosed are methods for increasing the patency of biodegradable, synthetic vascular grafts using a composition that inhibits Endo-MT. A cell-free tissue engineered vascular graft (TEVG) produced by this method is also disclosed.

US Patent:

20150053702, Feb 26, 2015

Filed:

Oct 2, 2014

Appl. No.:

14/505331

Inventors:

Peter Hollister BREWSTER - Hillsborough CA, US
Michael SIMONS - Hillsborough CA, US

International Classification:

A47G 19/22

US Classification:

220703

Abstract:

An apparatus can include a generally planar portion approximately in a plane. The apparatus can also include a lip portion extending in a direction generally orthogonal to the plane. The generally planar portion is joined to the lip portion at a circumferential edge of the generally planar portion to form a cover for a beverage container. Likewise, a method can include providing contact information on a disposable cover adapted to cover a beverage container. The contact information is not necessarily provided by the manufacturer of the beverage or beverage container. The method can also include receiving contact from a user of the disposable cover. The method can further include coordinating the delivery of a service to the user of the disposable cover responsive to the contact received from the user.