Michael J Simpson

US Patent:

6399951, Jun 4, 2002

Filed:

Feb 2, 2000

Appl. No.:

09/496880

Inventors:

Michael J. Paulus - Knoxville TN
Hamed Sari-Sarraf - Lubbock TX
Michael L. Simpson - Knoxville TN

Assignee:

UT-Battelle, LLC - Oak Ridge TN

International Classification:

G01T 1161

US Classification:

25037013, 25036304

Abstract:

A method for simultaneous transmission x-ray computed tomography (CT) and single photon emission tomography (SPECT) comprises the steps of: injecting a subject with a tracer compound tagged with a -ray emitting nuclide; directing an x-ray source toward the subject; rotating the x-ray source around the subject; emitting x-rays during the rotating step; rotating a cadmium zinc telluride (CZT) two-sided detector on an opposite side of the subject from the source; simultaneously detecting the position and energy of each pulsed x-ray and each emitted -ray captured by the CZT detector; recording data for each position and each energy of each the captured x-ray and -ray; and, creating CT and SPECT images from the recorded data. The transmitted energy levels of the x-rays lower are biased lower than energy levels of the -rays. The x-ray source is operated in a continuous mode.

US Patent:

6498349, Dec 24, 2002

Filed:

Aug 5, 1999

Appl. No.:

09/368919

Inventors:

Clarence E. Thomas - Knoxville TN
Larry R. Baylor - Farragut TN
Edgar Voelkl - Oak Ridge TN
Michael L. Simpson - Knoxville TN
Michael J. Paulus - Knoxville TN
Douglas H. Lowndes - Knoxville TN
John H. Whealton - Oak Ridge TN
John C. Whitson - Clinton TN
John B. Wilgen - Oak Ridge TN

Assignee:

UT-Battelle - Oakridge TN

International Classification:

H01J 37073

US Classification:

250398, 250397, 250423 F

Abstract:

Systems and methods are described for addressable field emission array (AFEA) chips. A method of operating an addressable field-emission array, includes: generating a plurality of electron beams from a pluralitly of emitters that compose the addressable field-emission array; and focusing at least one of the plurality of electron beams with an on-chip electrostatic focusing stack. The systems and methods provide advantages including the avoidance of space-charge blow-up.

US Patent:

6649431, Nov 18, 2003

Filed:

Feb 27, 2001

Appl. No.:

09/795660

Inventors:

Vladimir I. Merkulov - Knoxville TN
Douglas H. Lowndes - Knoxville TN
Michael A. Guillorn - Knoxville TN
Michael L. Simpson - Knoxville TN

Assignee:

UT. Battelle, LLC - Oak Ridge TN

International Classification:

H01L 2100

US Classification:

438 20, 438 70, 438 22, 313336, 445 49, 445 51, 257 13, 257 79, 423445 R, 423448

Abstract:

Systems and methods are described for carbon tips with expanded bases. A method includes producing an expanded based carbon containing tip including: fabricating a carbon containing expanded base on a substrate; and then fabricating a carbon containing fiber on the expanded base. An apparatus includes a carbon containing expanded base coupled to a substrate; and a carbon containing fiber coupled to said carbon containing expanded base.

US Patent:

6673596, Jan 6, 2004

Filed:

Dec 2, 1999

Appl. No.:

09/454071

Inventors:

Gary S. Sayler - Blain TN
Michael L. Simpson - Knoxville TN
Bruce M. Applegate - Knoxville TN
Steven A. Ripp - Knoxville TN

Assignee:

UT-Battelle, LLC - Oak Ridge TN
University of Tennessee Research Corporation - Knoxville TN

International Classification:

C12M 300

US Classification:

4352887, 4352882, 4352885, 435 71, 435 8, 422 55, 422 58, 422 61, 422 8205

Abstract:

Disclosed are bioluminescent bioreporter integrated circuit devices that detect selected analytes in fluids when implanted in the body of an animal. The device comprises a bioreporter that has been genetically engineered to contain a nucleic acid segment that comprises a cis-activating response element that is responsive to the selected substance operably linked to a gene encoding a bioluminescent reporter polypeptide. In preferred embodiments, the target analyte is glucose, glucagons, or insulin. Exposure of the bioreporter to the target substance causes the response element to up-regulate the nucleic acid sequence encoding the reporter polypeptide to produce a luminescent response that is detected and quantitated. In illustrative embodiments, the bioreporter device is encapsulated on an integrated circuit that is capable of detecting the emitted light, processing the resultant signal, and then remotely reporting the results. Also disclosed are controlled drug delivery systems capable of being directly or indirectly controlled by the detection device that provide drugs such as insulin to the animal in reponse to the amount of target analyte present in the body fluids.

US Patent:

6692324, Feb 17, 2004

Filed:

Mar 15, 2001

Appl. No.:

09/810531

Inventors:

Michael L. Simpson - Knoxville TN
Douglas H. Lowndes - Knoxville TN
Vladimir I. Merkulov - Knoxville TN
Michael A. Guillorn - Knoxville TN
Charles L. Britton - Alcoa TN

Assignee:

UT-Battelle, LLC - Oak Ridge TN

International Classification:

H01J 902

US Classification:

445 24, 313309, 313311

Abstract:

Systems and methods are described for a single self-aligned carbon nanofiber emitters within a dielectric well. A method, includes: providing a substrate; defining lithographically a catalyst particle, the catalyst particle coupled to the substrate; depositing a dielectric layer, the dielectric layer coupled to the substrate; depositing an extractor layer, the extractor layer coupled to the dielectric layer; forming an extractor aperture in the extractor layer; forming a dielectric well in the dielectric layer to uncover the catalyst particle; and then fabricating at a location of the catalyst particle and within the dielectric well a single self-aligned carbon containing tip i) having a base located substantially at the bottom of the dielectric well and ii) extending substantially away from the substrate using plasma enhanced chemical vapor deposition.

US Patent:

6858455, Feb 22, 2005

Filed:

May 24, 2002

Appl. No.:

10/155841

Inventors:

Michael L. Simpson - Knoxville TN, US
Vladimir I. Merkulov - Knoxville TN, US
Anatoli V. Melechko - Knoxville TN, US
Douglas H. Lowndes - Knoxville TN, US

Assignee:

UT-Battelle, LLC - Oak Ridge TN

International Classification:

H01L021/00

US Classification:

438 20, 445 24, 445 50

Abstract:

Gated field emission devices and systems and methods for their fabrication are described. A method includes growing a substantially vertically aligned carbon nanostructure, the substantially vertically aligned carbon nanostructure coupled to a substrate; covering at least a portion of the substantially vertically aligned carbon nanostructure with a dielectric; forming a gate, the gate coupled to the dielectric; and releasing the substantially vertically aligned carbon nanostructure by forming an aperture in the gate and removing a portion of the dielectric.

US Patent:

6905834, Jun 14, 2005

Filed:

Sep 12, 2000

Appl. No.:

09/660581

Inventors:

Michael L. Simpson - Knoxville TN, US
Michael J. Paulus - Knoxville TN, US
Gary S. Sayler - Knoxville TN, US
Bruce M. Applegate - Knoxville TN, US
Steven A. Ripp - Knoxville TN, US

Assignee:

UT-Battelle, LLC - Oak Ridge TN

International Classification:

G01N033/554

US Classification:

435 732, 422 55, 422 57, 422 58, 422 8201, 422 8205, 422 8206, 422 8207, 422 8208, 4352871, 4352872, 4352887, 435808, 436805

Abstract:

Disclosed are monolithic bioelectronic devices comprising a bioreporter and an OASIC. These bioluminescent bioreporter integrated circuit are useful in detecting substances such as pollutants, explosives, and heavy-metals residing in inhospitable areas such as groundwater, industrial process vessels, and battlefields. Also disclosed are methods and apparatus for detection of particular analytes, including ammonia and estrogen compounds.

US Patent:

6917043, Jul 12, 2005

Filed:

Sep 30, 2002

Appl. No.:

10/260321

Inventors:

Clarence E. Thomas - Knoxville TN, US
Larry R. Baylor - Farragut TN, US
Edgar Voelkl - Oak Ridge TN, US
Michael L. Simpson - Knoxville TN, US
Michael J. Paulus - Knoxville TN, US
Douglas Lowndes - Knoxville TN, US
John Whealton - Oak Ridge TN, US
John C. Whitson - Clinton TN, US
John B. Wilgen - Oak Ridge TN, US

Assignee:

UT-Battelle LLC - Oak Ridge TN

International Classification:

H01J037/073
H01J037/28
H01J037/302

US Classification:

250398, 250310, 2504922, 250423 F

Abstract:

Systems and method are described for addressable field emission array (AFEA) chips. A plurality of individually addressable cathodes are integrated with an electrostatic focusing stack and/or a plurality of detectors on the addressable field emission array. The systems and methods provide advantages including the avoidance of space-charge blow-up.