Michael B Slack

US Patent:

20060050946, Mar 9, 2006

Filed:

May 12, 2003

Appl. No.:

10/435827

Inventors:

Timothy Mitchison - Brookline MA, US
Steven Altschuler - Cambridge MA, US
Yan Feng - Andover MA, US
Thomas Mayer - Munchen, DE
Zachary Perlman - Boston MA, US
Michael Slack - La Mesa CA, US
Lani Wu - Cambridge MA, US

International Classification:

G06K 9/00

US Classification:

382133000

Abstract:

The present invention provides methods and systems for automated morphological analysis of cells. The inventive methods are particularly useful in the rapid analysis of cells required in a biological screen. Agents which cause a particular phenotype in the cells can be identified using the inventive quantitative morphometric analysis of cells. The data gathered using the inventive method can also be quantified and analyzed later for various trends and classifications. Characteristics of cells which can be determined using this method include number of nuclei, size of cell, size of nuclei, number of the centrosomes, shape of cells, size of centrosomes, perimeter of nucleus, shape of nucleus, pattern of staining, and degree of staining.