Michael J Springer

US Patent:

20200345828, Nov 5, 2020

Filed:

May 18, 2020

Appl. No.:

16/877015

Inventors:

- ALACHUA FL, US
MICHAEL SPRINGER - FOXBOROUGH MA, US
YAWEI NI - COLLEGE STATION TX, US

International Classification:

A61K 39/12
A61K 39/00
A61K 39/295
A61K 9/00
A61K 9/16
A61K 9/19

Abstract:

A dry powder norovirus vaccine is provided, which comprises at least two norovirus antigens representing different genogroups. The vaccine may be produced by formulation with a mixture of different antigens or combination of monovalent powders with each containing one antigen. The formulated vaccine is suitable for mucosal administration and soluble in aqueous solutions for parenteral administration. A method of immunization is also provided, which comprises at least one administration of the vaccine via mucosal and/or parental route. The immunization may have multiple administrations of the vaccine, i.e., one or more immunizations via a mucosal route followed by one or more immunizations via a parenteral route or vice versa, to maximize both mucosal and systemic immune responses and protection against norovirus infections.

US Patent:

20180243397, Aug 30, 2018

Filed:

Aug 26, 2016

Appl. No.:

15/754807

Inventors:

Ron COBB - Gainesville FL, US
Michael SPRINGER - Manchester CT, US
Yawei NI - College Station TX, US
- Alachua FL, US

International Classification:

A61K 39/12
A61K 9/00
A61K 9/19
A61K 9/16

Abstract:

A dry powder norovirus vaccine is provided, which comprises at least two norovirus antigens representing different genogroups. The vaccine may be produced by formulation with a mixture of different antigens or combination of monovalent powders with each containing one antigen. The formulated vaccine is suitable for mucosal administration and soluble in aqueous solutions for parenteral administration. A method of immunization is also provided, which comprises at least one administration of the vaccine via mucosal and/or parental route. The immunization may have multiple administrations of the vaccine, i.e., one or more immunizations via a mucosal route followed by one or more immunizations via a parenteral route or vice versa, to maximize both mucosal and systemic immune responses and protection against norovirus infections.