Michael D Swartz

US Patent:

7628920, Dec 8, 2009

Filed:

Apr 6, 2005

Appl. No.:

10/599583

Inventors:

Michael Swartz - Uxbridge MA, US
Uwe Dieter Neue - Ashland MA, US
Peter G. Alden - Whitinsville MA, US
Falk-Thilo Ferse - Berlin, DE

Assignee:

Waters Technologies Corporation - Milford MA

International Classification:

B01D 15/08

US Classification:

210635, 210656, 2101962

Abstract:

A liquid chromatography system comprising a chiral mobile phase used to separate enantiomeric molecules present in a sample is disclosed herein. In one aspect, the mobile phase comprises a chiral solvent. In another aspect, the mobile phase includes a chiral solvent but also a buffering agent. The liquid chromatography system described herein includes both high pressure liquid chromatography (HPLC) as well as high pressure capillary liquid chromatography (CapLC).

US Patent:

7977114, Jul 12, 2011

Filed:

Sep 30, 2005

Appl. No.:

11/240520

Inventors:

Michael Swartz - Uxbridge MA, US
Charles H. Fraiser - Hopkinton MA, US
Patricia Ann Fowler - Upton MA, US
Michael D. Jones - Narraganset RI, US

Assignee:

Waters Technologies Corporation - Milford MA

International Classification:

G01N 30/02
G01N 30/38

US Classification:

436161, 422 70, 73 6156, 2101982, 210656

Abstract:

Embodiments of the invention feature methods and apparatus for the efficient utilization of detectors and other components. The apparatus comprises a pump for receiving and propelling one or more samples in a fluid path. The apparatus further comprises a valve element in fluid communication with the pump for receiving the samples from the pump and directing the sample along one fluid path selected from a group. The group comprises a delay path comprising a delay volume, and a chromatography assembly having at least one chromatography column. The apparatus further comprises a detector or grouping of detectors in fluid communication with the delay path and the chromatography assembly for detecting compounds of interest to allow a single detector or single grouping of detectors to receive samples from the two fluid paths.

US Patent:

20100065492, Mar 18, 2010

Filed:

Oct 26, 2009

Appl. No.:

12/605520

Inventors:

Michael Swartz - Uxbridge MA, US
Uwe Dieter Neue - Ashland MA, US
Peter G. Alden - Whitinsville MA, US
Falk-Thilo Ferse - Berlin, DE

Assignee:

WATERS TECHNOLOGIES CORPORATION - Milford MA

International Classification:

B01D 15/38

US Classification:

2105021

Abstract:

A liquid chromatography system comprising a chiral mobile phase used to separate enantiomeric molecules present in a sample is disclosed herein. In one aspect, the mobile phase comprises a chiral solvent. In another aspect, the mobile phase includes a chiral solvent but also a buffering agent. The liquid chromatography system described herein includes both high pressure liquid chromatography (HPLC) as well as high pressure capillary liquid chromatography (CapLC).

US Patent:

60833726, Jul 4, 2000

Filed:

Feb 26, 1997

Appl. No.:

8/806300

Inventors:

Edward R. Grover - Randolph MA
Michael E. Swartz - Uxbridge MA
Jeffrey R. Mazzeo - Chelmsford MA

Assignee:

Waters Investments Limited - New Castle DE

International Classification:

G01N 2726

US Classification:

204451

Abstract:

The invention is in the field of electrokinetic chromatography. In particular, the invention is directed to reagents and methods of performing electrokinetic chromatography. The reagents and methods afford fast, high resolution separations with increased detectability.

US Patent:

60902507, Jul 18, 2000

Filed:

Mar 20, 1996

Appl. No.:

8/617916

Inventors:

Jeffrey R. Mazzeo - Chelmsford MA
Edward R. Grover - Randolph MA
Michael E. Swartz - Uxbridge MA
Michael Merion - Los Gatos CA
John S. Petersen - Acton MA

Assignee:

Waters Investments Limited - Wilmington DE

International Classification:

G01N 2726
G01N 27447

US Classification:

204451

Abstract:

Chiral surfactants, methods for their synthesis and use, and apparatus designed to facilitate chiral separations using nucellar capillary electrophoresis is disclosed. A chiral surfactant having the general formula: ##STR1## is described, R1 is the hydrophobic tail, Y-A-X is the linker, the brackets define a chiral center, and the hydrophilic head group is Z. All the various components may potentiate the enantioselectivity of the chiral surfactant. The capillary electrophoresis (CE) system includes a narrow diameter capillary, a high voltage power supply, an electrolyte reservoir at each end of the capillary, a means for injecting a sample, and a detector. Chiral surfactants are dissolved in the electrolyte above their critical micelle concentration (cmc), resulting in the formation of chiral micelles. The electrolyte reservoirs and capillary tube are filled with the electrolyte. A sample containing a mixture of enantiomers is then injected into the capillary, and a high voltage potential is applied across the capillary.