Michael A Teitell

US Patent:

20100284016, Nov 11, 2010

Filed:

May 6, 2009

Appl. No.:

12/436702

Inventors:

Michael A. Teitell - Tarzana CA, US
James K. Gimzewski - Topanga CA, US
Jason C. Reed - Los Angeles CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

G01J 3/45
G02B 21/24
G02B 21/36
G01B 9/021
G02B 3/10

US Classification:

356451, 359398, 359370, 359363, 356457, 359652

Abstract:

The present invention provides optical systems and methods for determining a characteristic of a cell, such as cell type, cellular response to a biochemical event, biological state and the like. The methods typically involve using interferometry to observe membrane properties in a cell and then use this information to determine one or more characteristics of a cell. The methods of the invention are useful for applications such as drug screening as well as diagnostic techniques.

US Patent:

20110117648, May 19, 2011

Filed:

Jul 25, 2008

Appl. No.:

12/667594

Inventors:

Pei-Yu Chiou - Los Angeles CA, US
Michael A. Teitell - Tarzana CA, US
Sheraz Kalim Butt - South San Francisco CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - OAKLAND

International Classification:

C12N 5/071
C12M 1/02
C12M 1/26
A61M 25/00
B82Y 5/00

US Classification:

435375, 4352831, 4353091, 427 228, 977773, 977762, 977774, 977810, 977838, 977902, 977901

Abstract:

This invention provides novel tools for surgery on single cells. In certain embodiments the tools comprise a microcapillary having at and/or near the tip a metal coating or a plurality of nanoparticles that can be heated by application of electromagnetic energy. In certain embodiments substrates are provided that facilitate the introduction of agents into cells. The substrates typically comprise a surface bearing a film or particles or nanoparticles that can be heated by application of electromagnetic energy.

US Patent:

20120236299, Sep 20, 2012

Filed:

Feb 9, 2012

Appl. No.:

13/370196

Inventors:

PEI-YU CHIOU - Los Angeles CA, US
SUNG-YONG PARK - Thousand Oaks CA, US
MICHAEL A. TEITELL - Tarzana CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

G05D 11/00
G01J 3/44
B05B 7/00
G01R 19/00
G01R 33/10
G01H 5/00
G01N 21/64
G01N 21/49

US Classification:

356301, 2504581, 356337, 324 7611, 324200, 73645, 137 8701, 239 10, 137 1, 239303

Abstract:

Methods and devices for the formation of droplets of a first fluid in a second fluid and the encapsulation of particles or cells within such droplets are disclosed. Impetus for droplet formation is provided by the creation of a transient bubble, which may be induced using a pulsed laser. Droplet volume and the frequency at which droplets are formed can be controlled by modulation of the pulsed laser. The disclosed methods and devices are particularly suitable for use in microfluidic devices.

US Patent:

20120283317, Nov 8, 2012

Filed:

Mar 7, 2012

Appl. No.:

13/413842

Inventors:

Michael A. Teitell - Tarzana CA, US
Carla M. Koehler - Los Angeles CA, US
Geng Wang - Los Angeles CA, US

International Classification:

A61K 31/7088
C12N 15/63
C12N 5/10
A61P 25/08
C07H 21/02
C07H 21/04
A61P 43/00
C12N 1/00
C12N 1/19

US Classification:

514 44 R, 4353171, 4353201, 435369, 4352542, 435354, 536 231

Abstract:

Disclosed herein recombinant and/or isolated nucleic acid molecules which comprise, consist essentially of, or consist of a first nucleic acid sequence, which is a wild-type sequence or an altered sequence, directly or indirectly linked to a second nucleic acid sequence selected from the group consisting of: (1) a mitochondria localization sequence, (2) an RNA import sequence, or (3) a combination thereof, and methods of using thereof.

US Patent:

20140080171, Mar 20, 2014

Filed:

Nov 25, 2013

Appl. No.:

14/088992

Inventors:

Jason C. Reed - Los Angeles CA, US
Michael A. Teitell - Tarzana CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

G01N 33/50

US Classification:

435 29, 4352887

Abstract:

The present invention provides optical systems and methods for determining a characteristic of a cell, such as cell type, cellular response to a biochemical event, biological state and the like. The methods typically involve using interferometry to observe membrane properties in a cell and then use this information to determine one or more characteristics of a cell. The methods of the invention are useful for applications such as drug screening as well as diagnostic techniques.

US Patent:

20210207150, Jul 8, 2021

Filed:

Mar 16, 2021

Appl. No.:

17/203620

Inventors:

- Oakland CA, US
Pei-Yu E. Chiou - Los Angeles CA, US
Michael A. Teitell - Tarzana CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C12N 15/64
C12M 1/42
C12N 13/00
C12N 15/87
C12N 5/071

Abstract:

Methods, devices, and systems are provided for the delivery of agents (e.g., nucleic acids, proteins, organic molecules, organelles, antibodies or other ligands, etc.) into live cells and/or the extraction of the same from said cells. In various embodiments the photothermal platforms and systems incorporating such photothermal platforms are provided that permit efficient, high-throughput cargo delivery into live cells.

US Patent:

20200199628, Jun 25, 2020

Filed:

Oct 14, 2019

Appl. No.:

16/601513

Inventors:

- Oakland CA, US
Pei-Yu E. Chiou - Los Angeles CA, US
Michael A. Teitell - Tarzana CA, US

International Classification:

C12N 15/89
C12M 1/42
C12N 15/87
C12M 1/12
C12M 1/26

Abstract:

In various embodiments, method and devices for delivering large cargos (e.g., organelles, chromosomes, bacteria, and the like) into cells are provided. In certain embodiments method of delivering a large cargo into eukaryotic cells, are provided that involve providing eukaryotic cells disposed on one side of a porous membrane; providing the cargo to be delivered in a solution disposed in a reservoir chamber on the opposite side of the porous membrane; and applying pressure to the reservoir chamber sufficient to pass the cargo through pores comprising said porous membrane wherein said cargo passes through cell membranes and into the cells.

US Patent:

20200116696, Apr 16, 2020

Filed:

Jul 3, 2018

Appl. No.:

16/626507

Inventors:

- Oakland CA, US
Michael A. Teitell - Tarzana CA, US
Xing Haw Marvin Tan - Jurong West, SG
Thang Nguyen - Fountain Valley CA, US

International Classification:

G01N 33/483
G01D 5/28
G01D 5/26
G01N 33/50

Abstract:

New platform technologies to actuate and sense force propagation in real-time for large sheets of cells are provided. In certain embodiments the platform comprises a device for the measurement of mechanical properties of cells or other moieties, where device comprises a transparent elastic or viscoelastic polymer substrate disposed on a rigid transparent surface; and a plurality of micromirrors disposed on or in said polymer substrate, wherein the reflective surfaces of the micromirrors are oriented substantially parallel to the surface of said polymer substrate. In certain embodiments the device comprises more than about 1,000,000, or more than about 10,000,000 micromirrors. In certain embodiments the micromirrors comprise a magnetic layer and/or a diffraction grating.