Michael Franklin Townsend

US Patent:

20090124512, May 14, 2009

Filed:

Jan 18, 2007

Appl. No.:

12/160784

Inventors:

Kathy L. Rowlen - Boulder CO, US
Robert Kuchta - Boulder CO, US
Michael Townsend - Atlanta GA, US
James Smagala - Arvada CO, US
Chad L. Moore - San Diego CA, US
Erica Dawson - Broomfield CO, US
Martin Mehlmann - Birsfelden, CH
Nancy Cox - Atlanta GA, US
Catherine B. Smith - Stone Mountain GA, US
Daniela Mehlmann - Birsfelden, CH

Assignee:

REGENTS OF THE UNIVERSITY OF COLORADO - Denver CO

International Classification:

C40B 40/06
C40B 50/00
C40B 30/04

US Classification:

506 9, 506 16, 506 23

Abstract:

Embodiments herein provide for methods, compositions and apparati for detection and/or diagnosis of virus types, subtypes and/or strains. In particular embodiments, the virus is an influenza virus. The apparatus may include a microarray with attached capture probes, designed to bind to oligonucleotides capable of binding at least a portion of a nucleic acid sequence of one or more target genes in a broad array of influenza types, subtypes or strains. The compositions may include isolated nucleic acids as capture probes, target sequences and/or tagged label probes, of use for diagnosis and/or detection of influenza virus.

US Patent:

20100273670, Oct 28, 2010

Filed:

Aug 21, 2007

Appl. No.:

12/438271

Inventors:

Kathy L. Rowlen - Boulder CO, US
Robert Kuchta - Boulder CO, US
Michael Townsend - Atlanta GA, US
James Smagala - Arvada CO, US
Erica Dawson - Broomfield CO, US

International Classification:

C40B 30/04
C40B 40/06
C40B 50/14

US Classification:

506 9, 506 16, 506 30

Abstract:

Embodiments of the present invention relate to compositions, methods and apparatus for detection of antiviral agent resistance or sensitivity of a virus. In some embodiments, antiviral agent resistance or sensitivity of influenza types, such as A, B and C may be identified. In more embodiments, sub-types such as the hemagglutinin (HA) and neuraminidase (NA) of influenza A may be analyzed for antiviral agent resistance or sensitivity. In a particular embodiment, the various strains of influenza virus may be analyzed for resistance or sensitivity using DNA microarray analysis designed to target a gene segment. In various embodiments, a microarray-based assay system with capture and detection (label) probes may be utilized to identify a change in a gene segment that confers resistance or sensitivity to an antiviral agent of an influenza strain.