Michael A Tracy

US Patent:

6362184, Mar 26, 2002

Filed:

Oct 17, 1997

Appl. No.:

08/951873

Inventors:

William W. Lee - Palo Alto CA
J. Martin Brown - Stanford CA
Edward W. Grange - Palo Alto CA
Abelardo P. Martinez - San Jose CA
Michael Tracy - Palo Alto CA
Daniel J. Pollart - Menlo Park CA

Assignee:

SRI International - Menlo Park CA

International Classification:

A61K 3153

US Classification:

514243, 5142325, 5142342, 514 84

Abstract:

A method of using 1,2,4-benzotriazine oxides, some of which are novel compounds, as radiosensitizers and selective cytotoxic agents is disclosed. These compounds are shown to specifically radiosensitive hypoxic tumor cells. Some are additionally disclosed to be useful as specific cytotoxic agents for these cells. They also show an unexpected ability to radiosensitize aerobic cells following or preceding a hypoxic incubation of the cells with the drug. This provides a basis for selective radiosensitization of tumors compared to normal cells. A novel method for preparing the 1,2,4-benzotriazine oxides is also disclosed.

US Patent:

6828321, Dec 7, 2004

Filed:

Dec 17, 2001

Appl. No.:

10/022678

Inventors:

William W. Lee - Palo Alto CA
J. Martin Brown - Stanford CA
Edward W. Grange - Palo Alto CA
Abelardo P. Martinez - San Jose CA
Michael Tracy - Palo Alto CA
Daniel J. Pollart - Menlo Park CA

Assignee:

SRI International - Menlo Park CA

International Classification:

A61K 3153

US Classification:

514243, 5142325, 5142342

Abstract:

A method of using 1,2,4-benzotriazine oxides, some of which are novel compounds, as radiosensitizers and selective cytotoxic agents is disclosed. These compounds are shown to specifically radiosensitize hypoxic tumor cells. Some are additionally disclosed to be useful as specific cytotoxic agents for these cells. They also show an unexpected ability to radiosensitize aerobic cells following or preceding a hypoxic incubation of the cells with the drug. This provides a basis for selective radiosensitization of tumors compared to normal cells. A novel method for preparing the 1,2,4-benzotriazine oxides is also disclosed.

US Patent:

7269182, Sep 11, 2007

Filed:

Oct 22, 2001

Appl. No.:

10/035506

Inventors:

David M. Carrel - Belvedere CA, US
Che-Lin Ho - Zephyr Cove NV, US
Thomas M. Stoner - Raleigh NC, US
Michael D. Tracy - Foster City CA, US

Assignee:

Redback Networks Inc. - San Jose CA

International Classification:

H04J 3/26

US Classification:

370432, 370466, 370390

Abstract:

A method and apparatus for PPPoE multicast is described. A computer implemented method comprises determining a PPPoE client to be multicast capable, determining a layer 2 multicast channel from a layer 3 multicast channel, and transmitting multicast traffic for the layer 2 multicast channel as PPPoE multicast traffic in a PPPoE multicast session to the PPPoE client.

US Patent:

20050078668, Apr 14, 2005

Filed:

Oct 8, 2003

Appl. No.:

10/682514

Inventors:

Joel Wittenberg - El Cerrito CA, US
Robert Kilfoyle - Campbell CA, US
Michael Tracy - Foster City CA, US
Thomas Stoner - Raleigh NC, US

International Classification:

H04L012/56

US Classification:

370389000, 370238000

Abstract:

A method and apparatus for providing redirect services are described herein. According to one embodiment, there is a service selection network element used to provide access of computing devices to a set of one or more services provided by one or more providers. In addition, the service selection network element includes a redirect facility and a set of routing policies stored in a machine readable medium within the service selection network element to handle redirect services within the service selection network element. Furthermore, the routing policies optionally include one or more replacement routing policies for each of the routing policy corresponding to the respective context. Other methods and apparatuses are also described.

US Patent:

20050153961, Jul 14, 2005

Filed:

Dec 3, 2004

Appl. No.:

11/003809

Inventors:

William Lee - Palo Alto CA, US
J. Brown - Stanford CA, US
Edward Grange - Palo Alto CA, US
Abelardo Martinez - San Jose CA, US
Michael Tracy - Palo Alto CA, US
Daniel Pollart - Menlo Park CA, US

International Classification:

A61K031/5377
A61K031/53

US Classification:

514234200, 514243000

Abstract:

A method of using 1,2,4-benzotriazine oxides, some of which are novel compounds, as radiosensitizers and selective cytotoxic agents is disclosed. These compounds are shown to specifically radiosensitize hypoxic tumor cells. Some are additionally disclosed to be useful as specific cytotoxic agents for these cells. They also show an unexpected ability to radiosensitize aerobic cells following or preceding a hypoxic incubation of the cells with the drug. This provides a basis for selective radiosensitization of tumors compared to normal cells. A novel method for preparing the 1,2,4-benzotriazine oxides is also disclosed.

US Patent:

58497382, Dec 15, 1998

Filed:

May 30, 1995

Appl. No.:

8/453329

Inventors:

William W. Lee - Palo Alto CA
J. Martin Brown - Stanford CA
Edward W. Grange - Palo Alto CA
Abelardo P. Martinez - San Jose CA
Michael Tracy - Palo Alto CA
Daniel J. Pollart - Menlo Park CA

Assignee:

SRI International - Menlo Park CA

International Classification:

A61K 3153
A61K 31535

US Classification:

514243

Abstract:

A method of using 1,2,4-benzotriazine oxides, some of which are novel compounds, as radiosensitizers and selective cytotoxic agents is disclosed. These compounds are shown to specifically radiosensitize hypoxic tumor cells. Some are additionally disclosed to be useful as specific cytotoxic agents for these cells. They also show an unexpected ability to radiosensitize aerobic cells following or preceding a hypoxic incubation of the cells with the drug. This provides a basis for selective radiosensitization of tumors compared to normal cells. A novel method for preparing the 1,2,4-benzotriazine oxides is also disclosed.

US Patent:

57212651, Feb 24, 1998

Filed:

Jun 2, 1995

Appl. No.:

8/458178

Inventors:

Michael Tracy - Palo Alto CA
Andrew B. Kelson - San Carlos CA
Paul Workman - Wilmslow, GB2
Alexander D. Lewis - Bearsden, GB6
Eric O. Aboagye - Bearsden, GB6

Assignee:

SRI International - Menlo Park CA

International Classification:

C07D23302
C07D23304
C07D23354
C07D23328
C07D23368
A61K 31415

US Classification:

514396

Abstract:

Agents useful for detecting hypoxic tumor cells are provided. The compounds have the structural formula (I) ##STR1## Methods of using the compounds to detect hypoxic tumor cells are also provided, as are pharmaceutical compositions formulated with the novel compounds.

US Patent:

47058501, Nov 10, 1987

Filed:

Nov 23, 1984

Appl. No.:

6/674175

Inventors:

Edward M. Acton - Menlo Park CA
Kenneth J. Ryan - Sunnyvale CA
Michael Tracy - Menlo Park CA

Assignee:

SRI International - Menlo Park CA

International Classification:

C07H 702
C07H 1524

US Classification:

536 11

Abstract:

Disclosed herein is a new procedure for preparing the C. 1-2,4-pentadienyl derivatives of 2-deoxyhexopyranoses, as well as a new procedure for allylation of daunosamine. These methods are particularly useful for the preparation of intermediates in the synthesis of adriamycin C-glycosidic analogs which are useful anti-tumor agents. These methods provide the first enabling disclosure of methods to prepare these desired adriamycin and anthrocyclinone C-glycosidic analogs.