Michael J Webb

US Patent:

57600708, Jun 2, 1998

Filed:

Aug 12, 1997

Appl. No.:

8/909799

Inventors:

Richard Eric Mewshaw - Princeton NJ
Michael Byron Webb - Levittown PA

Assignee:

American Home Products Corporation - Madison NJ

International Classification:

A61K 3140
C07D40912

US Classification:

514414

Abstract:

A compound of the formula I: ##STR1## in which Y is hydrogen, halogen or alkoxy; R is hydrogen or alkylthio; R. sub. 1 is hydrogen or alkyl; X is hydrogen, halogen, alkoxy, alkyl or phenyl; n is one of the integers 1, 2, 3 or 4; or a pharmaceutically acceptable salt thereof are inhibitors of dopamine synthesis and release, useful in the treatment of schizophrenia, Parkinson's Disease, Tourette's Syndrome, alcohol addiction, cocaine addiction, and addiction to analogous drugs.

US Patent:

59589655, Sep 28, 1999

Filed:

Aug 12, 1997

Appl. No.:

8/909803

Inventors:

Richard Eric Mewshaw - Princeton NJ
Michael Byron Webb - Levittown PA

Assignee:

American Home Products Corporation - Madison NJ

International Classification:

A01N 4338
C07D20904

US Classification:

514415

Abstract:

Compounds of the formula: ##STR1## in which R. sub. 1 is hydrogen, alkyl, cycloalkylalkyl, arylalkyl, (haloaryl)alkyl, (alkoxyaryl)alkyl, thienylmethyl, furanylmethyl, pyridinylmethyl, alkylphenyl, 4-fluorobutyrophenone or 6-fluoro-1,2-benzisoxazol-yl-propyl; X is hydrogen, halogen, cyano, alkyl, acetyl, trifluoroacetyl, trifluoromethyl or formyl; Y is hydrogen, halogen, alkoxy or alkyl; or a pharmaceutically acceptable salt thereof are inhibitors of dopamine synthesis and release, useful in the treatment of schizophrenia, Parkinson's Disease, Tourette's Syndrome, alcohol addiction, cocaine addiction, and addiction to analagous drugs and they also have affinity for the 5-HT. sub. 1A receptors which characterizes them as useful in the treatment of diseases attending disturbances in the serotinergic systems, such as anxiety, stress, depression, sexual dysfunctions and sleep disturbances.