Michael R Weiner

US Patent:

20100022414, Jan 28, 2010

Filed:

Jul 17, 2009

Appl. No.:

12/504764

Inventors:

Darren Link - Lexington MA, US
Brian Hutchison - Arlington MA, US
Michael Samuels - Windham NH, US
Michael Weiner - Guilford CT, US

Assignee:

Raindance Technologies, Inc. - Lexington MA

International Classification:

C40B 40/10
C40B 40/04
C40B 50/08

US Classification:

506 18, 506 15, 506 27

Abstract:

The present invention generally relates to droplet libraries and to systems and methods for the formation of libraries of droplets. The present invention also relates to methods utilizing these droplet libraries in various biological, chemical, or diagnostic assays.

US Patent:

20100137163, Jun 3, 2010

Filed:

Jun 1, 2006

Appl. No.:

12/087713

Inventors:

Darren R. Link - Lexington MA, US
Laurent Boitard - Paris, FR
Jeffrey Branciforte - Cromwell CT, US
Yves Charles - Waterbury CT, US
Gilbert Feke - Durham CT, US
John Q. Lu - Plano TX, US
David Marran - Durham CT, US
Ahmadali Tabatabai - Branford CT, US
Michael Weiner - Guilford CT, US
Wolfgang Hinz - Guilford CT, US
Jonathan M. Rothberg - Guilford CT, US

International Classification:

C40B 40/06
C40B 60/14
C40B 60/08
C40B 50/14

US Classification:

506 16, 506 40, 506 37, 506 30

Abstract:

The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. Such methods can include labeling a library of compounds by emulsifying aqueous solutions of the compounds and aqueous solutions of unique liquid labels on a microfluidic device, which includes a plurality of electrically addressable, channel bearing fluidic modules integrally arranged on a microfabricated substrate such that a continuous channel is provided for flow of immiscible fluids, whereby each compound is labeled with a unique liquid label, pooling the labeled emulsions, coalescing the labeled emulsions with emulsions containing a specific cell or enzyme, thereby forming a nanoreactor, screening the nanoreactors for a desirable reaction between the contents of the nanoreactor, and decoding the liquid label, thereby identifying a single compound from a library of compounds.

US Patent:

20110267457, Nov 3, 2011

Filed:

Dec 19, 2008

Appl. No.:

12/809120

Inventors:

David A Weitz - Bolton MA, US
Jeremy Agresti - Cambridge, MA
Michael P. Weiner - Guilford CT, US
Adam R. Abate - Somerville MA, US
Tony Hung - Peachtree GA, US

International Classification:

C40B 30/04
C07H 1/00
H04N 7/18
G01N 33/53

US Classification:

348135, 436501, 506 9, 536 253, 348E07085

Abstract:

The present invention relates to systems and methods for sequencing nucleic acids, including sequencing nucleic acids in fluidic droplets. In one set of embodiments, the method employs sequencing by hybridization using droplets such as microfluidic droplets. In some embodiments, droplets are formed which include a target nucleic acid, a nucleic acid probe, and at least one identification element, such as a fluorescent particle. The nucleic acid probes that hybridize to the target nucleic acid are determined, in some instances, by determining the at least one identification element. The nucleic acid probes that hybridize to the target nucleic acid may be used to determine the sequence of the target nucleic acid. In certain instances, the microfluidic droplets are provided with reagents that modify the nucleic acid probe. In some cases, a droplet, such as those described above, is deformed such that the components of the droplets individually pass a target area.

US Patent:

20130090248, Apr 11, 2013

Filed:

Sep 27, 2012

Appl. No.:

13/629227

Inventors:

Darren R. Link - Lexington MA, US
Michael Weiner - Guilford CT, US
David Marran - Durham CT, US
Jonathan M. Rothberg - Guilford CT, US

International Classification:

C12Q 1/68

US Classification:

506 2, 506 9

Abstract:

The present invention provides novel microfluidic substrates and methods that are useful for performing biological, chemical and diagnostic assays. The substrates can include a plurality of electrically addressable, channel bearing fluidic modules integrally arranged such that a continuous channel is provided for flow of immiscible fluids.

US Patent:

20130183659, Jul 18, 2013

Filed:

Feb 20, 2013

Appl. No.:

13/772002

Inventors:

Darren R. Link - Lexington MA, US
Michael Weiner - Guilford CT, US
David Marran - Durham CT, US
Jonathan M. Rothberg - Guilford CT, US

International Classification:

G01N 27/327

US Classification:

435 5, 435 612

Abstract:

The present invention provides novel microfluidic substrates and methods that are useful for performing biological, chemical and diagnostic assays. The substrates can include a plurality of electrically addressable, channel bearing fluidic modules integrally arranged such that a continuous channel is provided for flow of immiscible fluids.

US Patent:

20130210639, Aug 15, 2013

Filed:

Feb 28, 2013

Appl. No.:

13/779943

Inventors:

Darren R. Link - Lexington MA, US
Michael Weiner - Guilford CT, US
David Marran - Durham CT, US
Jonathan M. Rothberg - Guilford CT, US

International Classification:

C12N 15/10
C12Q 1/68

US Classification:

506 2, 435 612, 435 912, 506 26

Abstract:

The present invention provides novel microfluidic substrates and methods that are useful for performing biological, chemical and diagnostic assays. The substrates can include a plurality of electrically addressable, channel bearing fluidic modules integrally arranged such that a continuous channel is provided for flow of immiscible fluids.

US Patent:

20130217583, Aug 22, 2013

Filed:

Feb 5, 2013

Appl. No.:

13/759660

Inventors:

Darren Link - Lexington MA, US
Laurent Boitard - Gullford CT, US
Jeffrey Branciforte - Cromwell CT, US
Yves Charles - Waterbury CT, US
Gilbert Feke - West Simsbury CT, US
John Q. Lu - Gullford CT, US
David Marran - Durham CT, US
Ahmadali Tabatabai - Branford CT, US
Michael Weiner - Guilford CT, US
Wolfgang Hinz - Guilford CT, US
Jonathan M. Rothberg - Guilford CT, US

International Classification:

C12Q 1/68
G01N 33/543

US Classification:

506 2, 506 9

Abstract:

The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. Such methods can include labeling a library of compounds by emulsifying aqueous solutions of the compounds and aqueous solutions of unique liquid labels on a microfluidic device, which includes a plurality of electrically addressable, channel bearing fluidic modules integrally arranged on a microfabricated substrate such that a continuous channel is provided for flow of immiscible fluids, whereby each compound is labeled with a unique liquid label, pooling the labeled emulsions, coalescing the labeled emulsions with emulsions containing a specific cell or enzyme, thereby forming a nanoreactor, screening the nanoreactors for a desirable reaction between the contents of the nanoreactor, and decoding the liquid label, thereby identifying a single compound from a library of compounds.

US Patent:

45845832, Apr 22, 1986

Filed:

Jun 30, 1983

Appl. No.:

6/509576

Inventors:

Paul S. Dennis - Northport NY
Anthony M. Kowalski - Miller Place NY
Michael Weiner - Huntington Station NY

Assignee:

Hazeltine Corporation - Commack NY

International Classification:

G01S 316
G01S 328

US Classification:

343380

Abstract:

An LMS adaptive control loop module for reducing the effects of received interference includes a single antenna coupled to a first hybrid for generating a reference channel and an auxiliary channel. The auxiliary channel provides I/Q signals from a second hybrid and I/Q drive signals from I/Q correlation multipliers which are used to weight the I/Q signals from said second hybrid. The weighted signals and the reference channel signals are combined and provide an output.