Michael S Weingarten

US Patent:

20110124987, May 26, 2011

Filed:

Apr 21, 2009

Appl. No.:

12/937590

Inventors:

Elisabeth S. Papazoglou - Yardley PA, US
Michael S. Weingarten - Penn Valley PA, US
Leonid Zubkov - Philadelphia, PA
Michael T. Neidrauer - Drexel Hill PA, US
Linda Zhu - Newtown PA, US
Kambiz Pourrezaei - Gladwyne PA, US

International Classification:

A61B 5/1455

US Classification:

600310

Abstract:

Optical changes of tissue during wound healing measured by Near Infrared and Diffuse Reflectance Spectroscopy are shown to correlate with histologic changes. Near Infrared absorption coefficient correlated with blood vessel in-growth over time, while Diffuse Reflectance Spectroscopy (DRS) data correlated with collagen concentration. Changes of optical properties of wound tissue at greater depths are also quantified by Diffuse Photon Density Wave (DPDW) methodology at near infrared wavelengths. The diffusion equation for semi-infinite media is used to calculate the absorption and scattering coefficients based on measurements of phase and amplitude with a frequency domain or time domain device. An increase in the absorption and scattering coefficients and a decrease in blood saturation of the wounds compared to the non wounded sites was observed. The changes correlated with the healing stage of the wound. The methodologies used to collect information regarding the healing state of a wound may be used to clinically assess the efficacy of wound healing agents in a patient (e.g., a diabetic) and as a non-invasive method

US Patent:

20210139987, May 13, 2021

Filed:

Jan 2, 2021

Appl. No.:

17/140047

Inventors:

- Philadelphia PA, US
Sina Nassiri - Philadelphia PA, US
Michael Weingarten - Penn Valley PA, US

Assignee:

Drexel University - Philadelphia PA

International Classification:

C12Q 1/6881
G01N 33/569
C12Q 1/6883
A61K 38/21
C12Q 1/6886

Abstract:

One aspect of the invention provides a method of predicting whether a wound will heal. The method includes: obtaining a first measurement of a first macrophage phenotype population within a first sample obtained from a wound; obtaining a second measurement of a second macrophage phenotype population from the wound, wherein the second measurement of the second macrophage phenotype population is either: a different macrophage phenotype obtained from the first sample or the same macrophage phenotype obtained from a second, later sample from the wound; comparing the first measurement to the second measurement; and predicting whether the wound will heal based on a result of the comparing step.

US Patent:

20170247758, Aug 31, 2017

Filed:

Aug 14, 2015

Appl. No.:

15/500910

Inventors:

- Philadelphia PA, US
Sina NASSIRI - Philadelphia PA, US
Michael WEINGARTEN - Penn Valley PA, US

Assignee:

DREXEL UNIVERSITY - Philadelphia PA

International Classification:

C12Q 1/68
A61K 38/21
G01N 33/569

Abstract:

One aspect of the invention provides a method of predicting whether a wound will heal. The method includes: obtaining a first measurement of a first macrophage phenotype population within a first sample obtained from a wound; obtaining a second measurement of a second macrophage phenotype population from the wound, wherein the second measurement of the second macrophage phenotype population is either: a different macrophage phenotype obtained from the first sample or the same macrophage phenotype obtained from a second, later sample from the wound; comparing the first measurement to the second measurement; and predicting whether the wound will heal based on a result of the comparing step.

US Patent:

20160296158, Oct 13, 2016

Filed:

Nov 21, 2014

Appl. No.:

15/037778

Inventors:

- Philadelphia PA, US
Leonid Zubkov - Feasterville PA, US
Michael S. Weingarten - Penn Valley PA, US
Michael T. Neidrauer - Drexel Hill PA, US
David Diaz - Perth Amboy NJ, US

Assignee:

Drexel University - Philadelphia PA

International Classification:

A61B 5/00
A61B 5/1455

Abstract:

Multi-frequency Diffuse Photon Density Wave (DPDW) methodology at near infrared wavelengths is used to non-invasively measure the optical absorption and reduced scattering coefficients of tissue at depths of several millimeters to quantify the depth and degree of tissue damage. A digitally-controlled stepper motor and variable RF generator enable the user to select the distance between the light source and detector and the modulation frequency through software. This allows for the collection of virtually unlimited number of data points, enabling precise selection of the volume and depth of tissue that will be characterized.