Michael V West

US Patent:

6808704, Oct 26, 2004

Filed:

Sep 6, 2000

Appl. No.:

09/655815

Inventors:

Robert Lanza - Clinton MA
Michael D. West - Boston MA
Jose Cibelli - Holden MA

Assignee:

Advance Cell Technology, Inc. - Worcester MA

International Classification:

A01N 6300

US Classification:

424 937, 424 931, 4241841, 435325, 435346, 435375, 435377, 800 24

Abstract:

This invention relates to methods for making immune compatible tissues and cells for the purpose of transplantation and tissue engineering, using the techniques of nuclear transfer and cloning. Also encompassed are methods for determining the effect on immune compatibility of expressed transgenes and other genetic manipulations of the engineered cells and tissues.

US Patent:

7838727, Nov 23, 2010

Filed:

Nov 4, 2005

Appl. No.:

11/267555

Inventors:

Robert Lanza - Clinton MA, US
Young Chung - Shrewsbury MA, US
Michael D. West - Mill Valley CA, US

Assignee:

Advanced Cell Technology, Inc. - Marlborough MA

International Classification:

C12N 5/06
C12N 5/08
A61K 35/14

US Classification:

800 21, 435366, 435325

Abstract:

This present invention provides novel methods for deriving embryonic stem cells, those cells and cell lines, and the use of the cells for therapeutic and research purposes without the destruction of the embryo. It also relates to novel methods of establishing and storing an autologous stem cell line prior to implantation of an embryo, e. g. , in conjunction with reproductive therapies such as IVF.

US Patent:

8066750, Nov 29, 2011

Filed:

Oct 6, 2006

Appl. No.:

11/544839

Inventors:

Nelson Oi - Memphis TN, US
Wilder Companioni - Cordova TN, US
Jason Michael May - Cordova TN, US
Michael V. West - Somerville TN, US
Stephen Edward White - Germantown TN, US

Assignee:

Warsaw Orthopedic, Inc - Warsaw IN

International Classification:

A61B 17/80

US Classification:

606289

Abstract:

There is provided an orthopedic plate and port structures for the plate. The plate can be non-rigid and includes at least one hole for receiving an anchor or an anchor retaining device. The at least one hole can include a rigid port structure that prevents or resists deformation of the plate when the anchor or anchor retaining device is engaged thereto.

US Patent:

20020046410, Apr 18, 2002

Filed:

Mar 5, 2001

Appl. No.:

09/797684

Inventors:

Robert Lanza - Clinton MA, US
Michael West - Boston MA, US

International Classification:

A01K067/00
A61K049/00

US Classification:

800/003000, 800/008000, 424/009200

Abstract:

This invention relates to methods for making immune compatible tissues and cells for the purpose of transplantation and tissue engineering, using the techniques of nuclear transfer and cloning. Also encompassed are methods for determining the effect on immune compatibility of expressed transgenes and other genetic manipulations of the engineered cells and tissues.

US Patent:

20030217374, Nov 20, 2003

Filed:

Jan 15, 2003

Appl. No.:

10/342336

Inventors:

Michael West - Southborough MA, US

Assignee:

Advanced Cell Technology

International Classification:

A01K067/027

US Classification:

800/006000, 800/014000, 800/015000, 800/016000, 800/017000, 800/018000, 800/019000

Abstract:

This invention includes methods for producing non-human mammals expressing monoclonal or oligoclonal B or T lymphocytes, as well as embryonic and hematopoietic stem cells that differentiate into monoclonal or oligoclonal B or T cells, using cloning by nuclear transfer with a B or T cell of interest as the nuclear donor cell.

US Patent:

20030224345, Dec 4, 2003

Filed:

Aug 26, 2002

Appl. No.:

10/227282

Inventors:

Michael West - Southborough MA, US
Raymond Page - Southbridge MA, US
Hans Scholer - Kennett Square PA, US
Karen Chapman - SouthBorough MA, US

Assignee:

Advanced Cell Technology - Worcester MA

International Classification:

C12Q001/00
C12N005/06
C12N005/08

US Classification:

435/004000, 435/366000, 435/353000, 435/354000, 435/350000, 435/351000

Abstract:

The invention relates to assays for screening growth factors, adhesion molecules, immunostimulatory molecules, extracellular matrix components and other materials, alone or in combination, simultaneously or temporally, for the ability to induce directed differentiation of pluripotent and multipotent stem cells.

US Patent:

20030232430, Dec 18, 2003

Filed:

Nov 26, 2002

Appl. No.:

10/304020

Inventors:

Jose Cibelli - Holden MA, US
Michael West - Southborough MA, US
Keith Campbell - Loughborough, GB

Assignee:

Advanced Cell Technology - Worcester MA

International Classification:

C12N005/08

US Classification:

435/366000

Abstract:

Activated human embryos produced by therapeutic cloning can give rise to human totipotent and pluripotent stem cells from which autologous cells for transplantation therapy are derived. The present invention provides methods for producing activated human embryos that can be used to generate totipotent and pluripotent stem cells from which autologous cells and tissues suitable for transplantation can be derived. In one embodiment, the invention provides methods for producing activated human embryos by parthenogenesis; in another embodiment, the invention provides methods for producing activated human embryos by somatic cell nuclear transfer whereby the genetic material of a differentiated human donor cell is reprogrammed to form a diploid human pronudeus capable of directing a cell to generate the stem cells from which autologous, isogenic cells for transplantation therapy are derived. The ability to create autologous human embryos represents a critical step towards generating immune-compatible stem cells that can be used to overcome the problem of immune rejection in regenerative medicine. The activated human embryos produced by the present invention also provide model systems for identifying and analyzing the molecular mechanisms of epigenetic imprinting and the genetic regulation of embryogenesis and development.

US Patent:

20040018178, Jan 29, 2004

Filed:

Jan 22, 2003

Appl. No.:

10/348359

Inventors:

Michael West - Southborough MA, US

Assignee:

Advanced Cell Technology

International Classification:

A61K048/00

US Classification:

424/093210

Abstract:

The present invention provides cloned, genetically modified, endothelial cells, and the stem cells from which they are derived, which are produced by somatic cell nuclear transfer. The invention further provide novel therapeutic methods in which such cells are administered to a patient with tumors to inhibit and/or disrupt angiogenesis of the tumors, thereby inhibiting tumor growth and killing tumor cells.