Michael D West

US Patent:

6391554, May 21, 2002

Filed:

Nov 23, 1999

Appl. No.:

09/447151

Inventors:

Michael D. West - Boston MA
Jerry W. Shay - Dallas TX
Woodring E. Wright - Dallas TX
Nam Woo Kim - San Jose CA
Calvin B. Harley - Palo Alto CA
Scott L. Weinrich - Redwood City CA

Assignee:

Geron Corporation and Board of Regents - Menlo Park CA
The University of Texas Systems - Austin TX

International Classification:

C12Q 168

US Classification:

435 6, 435 15, 435 912, 435 72

Abstract:

Methods and kits are provided for diagnosis of specific cancerous conditions. The invention features a method for diagnosis of a condition in a patient associated with an elevated level of telomerase activity within a cell. The method involves determining the presence or amount of telomerase within the cells in the patient, e. g. by the use of the polymerase chain reaction. In one embodiment of the invention, the condition associated with elevated telomerase activity is chosen from prostate cancer, breast cancer, colon cancer, renal cancer, ovarian/cervical cancer, lung cancer, and leukemia. The invention allows cancer to be detected even in tissues and cells which are not positive by pathology.

US Patent:

20020174449, Nov 21, 2002

Filed:

Mar 25, 2002

Appl. No.:

10/103806

Inventors:

Michael West - Boston MA, US
Jose Cibelli - Holden MA, US

International Classification:

A01K067/027

US Classification:

800/015000, 800/021000, 800/019000

Abstract:

The present invention concerns the use of chromosomal replacement techniques in the context of producing cloned and transgenic animals, in order to correct chromosome abnormalities or alter autosomal genotypes, and provide for novel breeding pairs by replacing the sex chromosome in animals to be cloned. Replacement of a sex chromosome, or an X or Y chromosome, will result in animals that are autosomally isogenic and sexually non-isogenic (AISN), with “autosomally isogenic” meaning that the paired sets of autosomes (non-sex chromosomes) in each animal are isogenic or identical. Also included in the invention are animals that are both “autosomally” and “allelically” isogenic whereby each particular pair of chromosomes is internally isogenic or identical within a single animal as well as between animals. Such animals are particularly useful in generating a line of cloned mammals using sexual reproduction, without having to undergo nuclear transfer in order to propagate cloned animals.

US Patent:

20030217374, Nov 20, 2003

Filed:

Jan 15, 2003

Appl. No.:

10/342336

Inventors:

Michael West - Southborough MA, US

Assignee:

Advanced Cell Technology

International Classification:

A01K067/027

US Classification:

800/006000, 800/014000, 800/015000, 800/016000, 800/017000, 800/018000, 800/019000

Abstract:

This invention includes methods for producing non-human mammals expressing monoclonal or oligoclonal B or T lymphocytes, as well as embryonic and hematopoietic stem cells that differentiate into monoclonal or oligoclonal B or T cells, using cloning by nuclear transfer with a B or T cell of interest as the nuclear donor cell.

US Patent:

20030224345, Dec 4, 2003

Filed:

Aug 26, 2002

Appl. No.:

10/227282

Inventors:

Michael West - Southborough MA, US
Raymond Page - Southbridge MA, US
Hans Scholer - Kennett Square PA, US
Karen Chapman - SouthBorough MA, US

Assignee:

Advanced Cell Technology - Worcester MA

International Classification:

C12Q001/00
C12N005/06
C12N005/08

US Classification:

435/004000, 435/366000, 435/353000, 435/354000, 435/350000, 435/351000

Abstract:

The invention relates to assays for screening growth factors, adhesion molecules, immunostimulatory molecules, extracellular matrix components and other materials, alone or in combination, simultaneously or temporally, for the ability to induce directed differentiation of pluripotent and multipotent stem cells.

US Patent:

20040018178, Jan 29, 2004

Filed:

Jan 22, 2003

Appl. No.:

10/348359

Inventors:

Michael West - Southborough MA, US

Assignee:

Advanced Cell Technology

International Classification:

A61K048/00

US Classification:

424/093210

Abstract:

The present invention provides cloned, genetically modified, endothelial cells, and the stem cells from which they are derived, which are produced by somatic cell nuclear transfer. The invention further provide novel therapeutic methods in which such cells are administered to a patient with tumors to inhibit and/or disrupt angiogenesis of the tumors, thereby inhibiting tumor growth and killing tumor cells.

US Patent:

20040040050, Feb 26, 2004

Filed:

Jun 6, 2003

Appl. No.:

10/276001

Inventors:

Michael West - Boston MA, US

International Classification:

A01K067/027
G06F017/60

US Classification:

800/014000, 800/019000, 705/001000, 119/300000

Abstract:

This invention describes a novel method of agricultural animal production that provides animals with optimum growth characteristics in a reliable and cost-effective manner. The invention utilizes a novel combination of Nuclear Transfer (NT) and Embryonic Stem (ES) cell technologies that improves the efficiency of delivering optimized animals and facilitates the introduction of genetic modifications into farm animals.

US Patent:

20040091936, May 13, 2004

Filed:

May 27, 2003

Appl. No.:

10/445195

Inventors:

Michael West - Southborough MA, US

International Classification:

G01N033/53
C12N005/08

US Classification:

435/007100, 435/325000, 435/366000

Abstract:

Methods for producing stem cell banks, preferably human, which optionally may be transgenic, e.g., comprised of homozygous MHC allele cell lines are provided. These cells are produced preferably from parthenogenic, IVF, or same-species or cross-species nuclear transfer embryos or by de-differentiation of somatic cells by cytoplasm transfer. Methods for using these stem cell banks for producing stem and differentiated cells for therapy, especially acute therapies, and for screening for drugs for disease treatment are also provided.

US Patent:

20040180430, Sep 16, 2004

Filed:

Mar 1, 2004

Appl. No.:

10/790640

Inventors:

Michael West - Boston MA, US
Jose Cibelli - Holden MA, US
Robert Lanza - Clinton MA, US

International Classification:

C12N005/08

US Classification:

435/366000

Abstract:

This invention relates to methods for rejuvenating primary cells and for making primary cells of a different type having the same genotype as a primary cell of interest. Also encompassed are methods of re-cloning cloned mammals, particularly methods where the offspring of cloned mammals are designed to be genetically altered in comparison to their cloned parent. Also included are methods for activating endogenous telomerase for the purpose of extending the life span of a primary cell.