Michael Allan West

US Patent:

6368789, Apr 9, 2002

Filed:

Jun 5, 1995

Appl. No.:

08/464011

Inventors:

Michael D. West - Belmont CA 94002
Jerry Shay - Dallas TX 75209
Woodring Wright - Arlington TX 76011
Elizabeth H. Blackburn - San Francisco CA 94127

International Classification:

C12Q 168

US Classification:

435 6, 435 721, 435 722, 435 74, 435 772, 435 9131

Abstract:

Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing the loss of telomeric repeats in aging cells.

US Patent:

6551774, Apr 22, 2003

Filed:

Aug 20, 1999

Appl. No.:

09/378535

Inventors:

Michael D. West - San Carlos CA
Calvin B. Harley - Palo Alto CA
Scott L. Weinrich - San Francisco CA
Catherine M. Strahl - San Francisco CA
Michael J. McEachern - San Francisco CA
Jerry Shay - Dallas TX
Woodring E. Wright - Arlington TX
Elizabeth H. Blackburn - San Francisco CA
Nam Woo Kim - Sunnyvale CA
Homayoun Vaziri - Toronto, CA

Assignee:

Board of Regents, The University of Texas System - Dallas TX
The Regents of the University of California - Oakland CA
Geron Corporation - Menlo Park CA

International Classification:

C12Q 168

US Classification:

435 6, 435 71, 435 15, 435 912, 435 915

Abstract:

Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to increase or decrease telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing or reversing the loss of telomeric repeats in aging cells.

US Patent:

6800480, Oct 5, 2004

Filed:

Aug 29, 2000

Appl. No.:

09/530346

Inventors:

Andrea G. Bodnar - Oshawa, CA
Joseph D. Gold - San Francisco CA
Margaret Inokuma - San Jose CA
James T. Murai - San Bruno CA
Michael D. West - Boston MA

Assignee:

Geron Corporation - Menlo Park CA

International Classification:

C12N 500

US Classification:

435325, 435 11, 424 931, 424 9321

Abstract:

Methods and materials for culturing primate-derived primordial stem cells are described. In one embodiment, a cell culture medium for growing primate-derived primordial stem cells in a substantially undifferentiated state is provided which includes a low osmotic pressure, low endotoxin basic medium that is effective to support the growth of primate-derived primordial stem cells. The basic medium is combined with a nutrient serum effective to support the growth of primate-derived primordial stem cells and a substrate selected from the group consisting of feeder cells and an extracellular matrix component derived from feeder cells. The medium further includes non-essential amino acids, an anti-oxidant, and a first growth factor selected from the group consisting of nucleosides and a pyruvate salt.

US Patent:

7413902, Aug 19, 2008

Filed:

Dec 24, 2002

Appl. No.:

10/330873

Inventors:

Andrea G. Bodnar - Oshawa, CA
Joseph D. Gold - San Francisco CA, US
Margaret Inokuma - San Jose CA, US
James T. Murai - San Bruno CA, US
Michael D. West - Boston MA, US

Assignee:

Geron Corporation - Menlo Park CA

International Classification:

C12N 5/02

US Classification:

435377, 435375

Abstract:

Methods and materials for culturing primate-derived primordial stem cells are described. In one embodiment, a cell culture medium for growing primate-derived primordial stem cells in a substantially undifferentiated state is provided which includes a low osmotic pressure, low endotoxin basic medium that is effective to support the growth of primate-derived primordial stem cells. The basic medium is combined with a nutrient serum effective to support the growth of primate-derived primordial stem cells and a substrate selected from feeder cells and an extracellular matrix component derived from feeder cells. The medium further includes non-essential amino acids, an anti-oxidant, and a first growth factor selected from nucleosides and a pyruvate salt.

US Patent:

D606447, Dec 22, 2009

Filed:

Aug 20, 2009

Appl. No.:

29/342252

Inventors:

Michael W. West - Eden Prairie MN, US
Ryan Graf - Chanhassen MN, US

Assignee:

Source, LLC - Hopkins MN

International Classification:

1101

US Classification:

D11 80

US Patent:

7910369, Mar 22, 2011

Filed:

Aug 24, 2005

Appl. No.:

11/211174

Inventors:

Michael D. West - Mill Valley CA, US
Karen B. Chapman - Mill Valley CA, US
Irina V. Klimanskaya - Upton MA, US

Assignee:

Advanced Cell Technology, Inc. - Santa Monica CA

International Classification:

C12N 5/00
C12N 5/02
C12N 5/071
C12N 5/07
C12N 5/10

US Classification:

435373, 435366, 435349

Abstract:

The present invention provides methods for the culture of animal pluripotent stem cells and their differentiated progeny cells, tissues, and organs, and nonhuman animal embryos and fetuses.

US Patent:

8597944, Dec 3, 2013

Filed:

Jun 29, 2011

Appl. No.:

13/172027

Inventors:

Michael D. West - Mill Valley CA, US
Karen B. Chapman - Mill Valley CA, US
Irina V. Klimanskaya - Upton MA, US

Assignee:

Advanced Cell Technology, Inc. - Worcester MA

International Classification:

C12N 5/071
C12N 5/00

US Classification:

435366, 435373

Abstract:

The present invention provides methods for the culture of animal pluripotent stem cells and their differentiated progeny cells, tissues, and organs, and nonhuman animal embryos and fetuses.

US Patent:

20020127634, Sep 12, 2002

Filed:

Jun 5, 1995

Appl. No.:

08/463404

Inventors:

MICHAEL D. WEST - BELMONT CA, US
JERRY SHAY - DALLS TX, US
WOODRING WRIGHT - ARLINGTON TX, US
ELIZABETH H. BLACKBURN - SAN FRANCISCO CA, US

International Classification:

G01N031/00
G01N035/00
G01N035/02
G01J003/42

US Classification:

435/046000, 356/320000, 436/043000, 436/050000, 436/008000, 436/015000

Abstract:

Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing the loss of telomeric repeats in aging cells.