Michael Dean West

US Patent:

6800480, Oct 5, 2004

Filed:

Aug 29, 2000

Appl. No.:

09/530346

Inventors:

Andrea G. Bodnar - Oshawa, CA
Joseph D. Gold - San Francisco CA
Margaret Inokuma - San Jose CA
James T. Murai - San Bruno CA
Michael D. West - Boston MA

Assignee:

Geron Corporation - Menlo Park CA

International Classification:

C12N 500

US Classification:

435325, 435 11, 424 931, 424 9321

Abstract:

Methods and materials for culturing primate-derived primordial stem cells are described. In one embodiment, a cell culture medium for growing primate-derived primordial stem cells in a substantially undifferentiated state is provided which includes a low osmotic pressure, low endotoxin basic medium that is effective to support the growth of primate-derived primordial stem cells. The basic medium is combined with a nutrient serum effective to support the growth of primate-derived primordial stem cells and a substrate selected from the group consisting of feeder cells and an extracellular matrix component derived from feeder cells. The medium further includes non-essential amino acids, an anti-oxidant, and a first growth factor selected from the group consisting of nucleosides and a pyruvate salt.

US Patent:

7413902, Aug 19, 2008

Filed:

Dec 24, 2002

Appl. No.:

10/330873

Inventors:

Andrea G. Bodnar - Oshawa, CA
Joseph D. Gold - San Francisco CA, US
Margaret Inokuma - San Jose CA, US
James T. Murai - San Bruno CA, US
Michael D. West - Boston MA, US

Assignee:

Geron Corporation - Menlo Park CA

International Classification:

C12N 5/02

US Classification:

435377, 435375

Abstract:

Methods and materials for culturing primate-derived primordial stem cells are described. In one embodiment, a cell culture medium for growing primate-derived primordial stem cells in a substantially undifferentiated state is provided which includes a low osmotic pressure, low endotoxin basic medium that is effective to support the growth of primate-derived primordial stem cells. The basic medium is combined with a nutrient serum effective to support the growth of primate-derived primordial stem cells and a substrate selected from feeder cells and an extracellular matrix component derived from feeder cells. The medium further includes non-essential amino acids, an anti-oxidant, and a first growth factor selected from nucleosides and a pyruvate salt.

US Patent:

7910369, Mar 22, 2011

Filed:

Aug 24, 2005

Appl. No.:

11/211174

Inventors:

Michael D. West - Mill Valley CA, US
Karen B. Chapman - Mill Valley CA, US
Irina V. Klimanskaya - Upton MA, US

Assignee:

Advanced Cell Technology, Inc. - Santa Monica CA

International Classification:

C12N 5/00
C12N 5/02
C12N 5/071
C12N 5/07
C12N 5/10

US Classification:

435373, 435366, 435349

Abstract:

The present invention provides methods for the culture of animal pluripotent stem cells and their differentiated progeny cells, tissues, and organs, and nonhuman animal embryos and fetuses.

US Patent:

8597944, Dec 3, 2013

Filed:

Jun 29, 2011

Appl. No.:

13/172027

Inventors:

Michael D. West - Mill Valley CA, US
Karen B. Chapman - Mill Valley CA, US
Irina V. Klimanskaya - Upton MA, US

Assignee:

Advanced Cell Technology, Inc. - Worcester MA

International Classification:

C12N 5/071
C12N 5/00

US Classification:

435366, 435373

Abstract:

The present invention provides methods for the culture of animal pluripotent stem cells and their differentiated progeny cells, tissues, and organs, and nonhuman animal embryos and fetuses.

US Patent:

20060112438, May 25, 2006

Filed:

Jan 3, 2005

Appl. No.:

11/028345

Inventors:

Michael West - Mill Valley CA, US
Karen Chapman - Mill Valley CA, US
Irina Klimanskaya - Upton MA, US

International Classification:

A01K 67/027
C12N 5/06
C12N 5/08

US Classification:

800017000, 435349000, 435366000

Abstract:

The present invention provides methods for the culture of animal pluripotent stem cells and their differentiated progeny cells, tissues, and organs, and nonhuman animal embryos and fetuses.

US Patent:

20070067860, Mar 22, 2007

Filed:

Jun 29, 2006

Appl. No.:

11/478780

Inventors:

Michael West - Mill Valley CA, US
Karen Chapman - Mill Valley CA, US
Irina Klimanskaya - Upton MA, US

International Classification:

A01K 67/027
C12N 5/08
C12N 5/06

US Classification:

800017000, 435325000, 435350000, 435366000

Abstract:

The present invention provides methods for the culture of animal pluripotent stem cells and their differentiated progeny cells, tissues, and organs, and nonhuman animal embryos and fetuses.

US Patent:

20070274954, Nov 29, 2007

Filed:

Aug 2, 2007

Appl. No.:

11/890127

Inventors:

Michael West - Mill Valley CA, US

Assignee:

Advanced Cell Technology, Inc. - Worcester MA

International Classification:

A61K 35/56
A01K 67/027
A61P 43/00
C12N 15/00

US Classification:

424093200, 435326000, 800014000, 800024000, 800006000

Abstract:

This invention includes methods for producing non-human mammals expressing monoclonal or oligoclonal B or T lymphocytes, as well as embryonic and hematopoietic stem cells that differentiate into monoclonal or oligoclonal B or T cells, using cloning by nuclear transfer with a B or T cell of interest as the nuclear donor cell.

US Patent:

20080070303, Mar 20, 2008

Filed:

Nov 21, 2006

Appl. No.:

11/604047

Inventors:

Michael West - Mill Valley CA, US
Geoffrey Sargent - San Lorenzo CA, US
James Murai - San Bruno CA, US
Steven Kessler - Belmont CA, US
Karen Chapman - Mill Valley CA, US

International Classification:

C12N 5/02
C12N 5/00

US Classification:

435377000

Abstract:

This invention generally relates to methods to differentiate pluripotent stem cells, such as embryonic stem, embryonic germ, or embryo-derived cells, to obtain subpopulations of cells from heterogeneous mixtures of cells wherein the subpopulation of cells possess reduced differentiation potential compared to the original pluripotent stem cells and where the subpopulation is capable of being propagated.