Michael Henry Winters

US Patent:

6797476, Sep 28, 2004

Filed:

Apr 1, 2002

Appl. No.:

10/113374

Inventors:

Russel Jackson Lander - Lansdale PA
Michael Albert Winters - Doylestown PA
Francis Jeremiah Meacle - London, GB

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

C12Q 168

US Classification:

435 6

Abstract:

The present invention relates to a nonchromatographic-based process for the isolation of clinical grade plasmid DNA from bacterial cells. The exemplified methods described herein outline a scaleable, economically favorable protocol for the purification of clinical grade plasmid DNA from which includes CTAB-based precipitation of DNA in combination with adsorption of impurities to calcium silicate.

US Patent:

7285651, Oct 23, 2007

Filed:

Aug 19, 2004

Appl. No.:

10/922324

Inventors:

Russel Jackson Lander - Lansdale PA, US
Michael Albert Winters - Doylestown PA, US
Francis Jeremiah Meacle - London, GB

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C12P 21/02

US Classification:

536 231, 4353201

Abstract:

The present invention relates to a nonchromatographic-based process for the isolation of clinical grade plasmid DNA from bacterial cells. The exemplified methods described herein outline a scaleable, economically favorable protocol for the purification of clinical grade plasmid DNA from which includes CTAB-based precipitation of DNA in combination with adsorption of impurities to calcium silicate.

US Patent:

7385066, Jun 10, 2008

Filed:

Mar 14, 2006

Appl. No.:

11/375503

Inventors:

Nalin L. Subasinghe - Exton PA, US
Shelley Ballentine - Lansdale PA, US
Jeremy M. Travins - Downingtown PA, US
Ehab M. Khalil - West Chester PA, US
Farah Ali - Exton PA, US
Kristi A. Leonard - West Chester PA, US
Joan M. Gushue - Harleysville PA, US
Michael Peter Winters - Morgantown PA, US
Heather Hufnagel - Glenmoore PA, US
Maxwell David Cummings - Strafford PA, US

Assignee:

Janssen Pharmaceutica N.V. - Beerse

International Classification:

C07D 333/34

US Classification:

549 66

Abstract:

Disclosed are compounds for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade. The compounds are of Formula I.

US Patent:

7767399, Aug 3, 2010

Filed:

Jan 27, 2006

Appl. No.:

11/795908

Inventors:

Jason C. Murphy - Ambler PA, US
David B. Boyd - Quakertown PA, US
Adam Joel Kristopeit - North Wales PA, US
Russel Jackson Lander - Lansdale PA, US
Michael Albert Winters - Doylestown PA, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

Methods of isolating clinical-grade plasmid DNA from manufacturing processes, including large-scale fermentation regimes, are disclosed which encompass alternatives to two core unit operations common to plasmid DNA purification processes. The novel upstream and downstream purification processes disclosed herein provide for reduced production costs and increase process robustness. Either or both of the purification processes disclosed herein may be used in combination with additional purification steps known in the art that are associated with DNA plasmid purification technology.

US Patent:

7868023, Jan 11, 2011

Filed:

Apr 3, 2008

Appl. No.:

12/061873

Inventors:

Nalin L. Subasinghe - Exton PA, US
Shelley Ballentine - Lansdale PA, US
Jeremy M. Travins - Downingtown PA, US
Ehab M. Khalil - West Chester PA, US
Farah Ali - Exton PA, US
Kristi A. Leonard - West Chester PA, US
Joan M. Gushue - Harleysville PA, US
Michael Peter Winters - Morgantown PA, US
Heather Hufnagel - Glenmoore PA, US
Maxwell David Cummings - Strafford PA, US

Assignee:

Janssen Pharmaceutica NV

International Classification:

A61K 31/381
A61K 31/44
C07D 409/12

US Classification:

514334, 514444, 5462804, 549 59

Abstract:

Disclosed are compounds for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade. The compounds are of Formula I.

US Patent:

8633322, Jan 21, 2014

Filed:

Oct 28, 2010

Appl. No.:

12/914244

Inventors:

Michael H. Parker - Chalfont PA, US
Dennis J. Hlasta - Doylestown PA, US
Yifang Huang - Lansdale PA, US
Allen B. Reitz - Lansdale PA, US
Edward C. Lawson - Pipersville PA, US
Carsten Schubert - Phoenixville PA, US
Eric Strobel - Warrington PA, US
Brett A. Tounge - Blue Bell PA, US
Kimberly White - North Wales PA, US
Michael P. Winters - Morgantown PA, US
Shyamali Ghosh - Norristown PA, US

Assignee:

Janssen Pharmaceutica NV

International Classification:

A61K 31/445
C07D 211/40

US Classification:

546216, 514326

Abstract:

The present invention is directed to novel alkynyl derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1.

US Patent:

20010044136, Nov 22, 2001

Filed:

Dec 21, 2000

Appl. No.:

09/745217

Inventors:

Russel Lander - Lansdale PA, US
Michael Winters - Doylestown PA, US
Francis Meacle - London, GB

International Classification:

C12P019/34
C12N015/87

US Classification:

435/091100, 435/320100

Abstract:

The present invention relates to a nonchromatographic-based process for the isolation of clinical grade plasmid DNA from bacterial cells. The exemplified methods described herein outline a scaleable, economically favorable protocol for the purification of clinical grade plasmid DNA from which includes CTAB-based precipitation of DNA in combination with adsorption of impurities to calcium silicate.

US Patent:

20020012990, Jan 31, 2002

Filed:

Jun 6, 2001

Appl. No.:

09/875379

Inventors:

Russel Lander - Lansdale PA, US
Michael Winters - Doylestown PA, US
Francis Meacle - London, GB

International Classification:

C12N015/64

US Classification:

435/320100

Abstract:

The present invention relates to a nonchromatographic-based process for the isolation of clinical grade plasmid DNA from bacterial cells. The exemplified methods described herein outline a scaleable, economically favorable protocol for the purification of clinical grade plasmid DNA from which includes CTAB-based precipitation of DNA in combination with adsorption of impurities to calcium silicate.