Michael R Winters

US Patent:

6797476, Sep 28, 2004

Filed:

Apr 1, 2002

Appl. No.:

10/113374

Inventors:

Russel Jackson Lander - Lansdale PA
Michael Albert Winters - Doylestown PA
Francis Jeremiah Meacle - London, GB

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

C12Q 168

US Classification:

435 6

Abstract:

The present invention relates to a nonchromatographic-based process for the isolation of clinical grade plasmid DNA from bacterial cells. The exemplified methods described herein outline a scaleable, economically favorable protocol for the purification of clinical grade plasmid DNA from which includes CTAB-based precipitation of DNA in combination with adsorption of impurities to calcium silicate.

US Patent:

7138420, Nov 21, 2006

Filed:

Aug 1, 2003

Appl. No.:

10/632888

Inventors:

Joerg Martin Bentzien - White Plains NY, US
Brian Nicholas Cook - Danbury CT, US
Charles Cywin - Bethel CT, US
Roman Wolfgang Fleck - Greenwich CT, US
Ho Yin Lo - Bethel CT, US
Peter Allen Nemoto - Southbury CT, US
Steven S. Pullen - Danbury CT, US
Gregory Paul Roth - Woodstock CT, US
Roger John Snow - Danbury CT, US
Hidenori Takahashi - LaGrangeville NY, US
Ji Wang - Danbury CT, US
Kevin J. Moriarty - East Norriton PA, US
Lei Qiao - Downingtown PA, US
Michael Winters - Morgantown PA, US

Assignee:

Boehringer Ingelheim Pharmaceuticals Inc. - Ridgefield CT

International Classification:

A61K 31/4184
C07D 235/30

US Classification:

514388, 5483047, 5483074, 548248, 5462734, 544121, 544132, 544370, 514378, 514338, 5142345, 51425406

Abstract:

Disclosed are substituted benzimidazole compounds of formula (I):.

US Patent:

7285651, Oct 23, 2007

Filed:

Aug 19, 2004

Appl. No.:

10/922324

Inventors:

Russel Jackson Lander - Lansdale PA, US
Michael Albert Winters - Doylestown PA, US
Francis Jeremiah Meacle - London, GB

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C12P 21/02

US Classification:

536 231, 4353201

Abstract:

The present invention relates to a nonchromatographic-based process for the isolation of clinical grade plasmid DNA from bacterial cells. The exemplified methods described herein outline a scaleable, economically favorable protocol for the purification of clinical grade plasmid DNA from which includes CTAB-based precipitation of DNA in combination with adsorption of impurities to calcium silicate.

US Patent:

7321041, Jan 22, 2008

Filed:

Apr 15, 2003

Appl. No.:

10/413980

Inventors:

Charles L. Cywin - Bethel CT, US
Scott E. Jakes - Southbury CT, US
Joachim Heider - Warthausen, DE
Mark A. Bobko - Exton PA, US
Renee L. Des Jarlais - St. Davids PA, US
Mark Player - Phoenixville PA, US
James Rinker - Reading PA, US
Michael Winters - Lancaster PA, US

Assignee:

Boehringer Ingelheim Pharmaceuticals, Inc. - Ridgefield CT

International Classification:

C07D 471/02

US Classification:

546122

Abstract:

Disclosed are compounds of formula (I):.

US Patent:

7678911, Mar 16, 2010

Filed:

Jan 15, 2008

Appl. No.:

12/014190

Inventors:

Charles L. Cywin - Bethel CT, US
Scott E. Jakes - Southbury CT, US
Joachim Heider - Warthausen, DE
Mark A. Bobko - Exton PA, US
Renee L. Des Jarlais - St. Davids PA, US
Mark Player - Phoenixville PA, US
James Rinker - Reading PA, US
Michael Winters - Lancaster PA, US

Assignee:

Boehringer Ingelheim Pharmaceuticals, Inc. - Ridgefield CT

International Classification:

C07D 471/02
C07D 413/00

US Classification:

546122, 544127

Abstract:

Disclosed are compounds of formula (I):.

US Patent:

7705151, Apr 27, 2010

Filed:

Mar 6, 2009

Appl. No.:

12/399292

Inventors:

Charles L. Cywin - Bethel CT, US
Scott E. Jakes - Southbury CT, US
Joachim Heider - Warthausen, DE
Mark A. Bobko - Exton PA, US
Renee L. Des Jarlais - St. Davids PA, US
Mark Player - Phoenixville PA, US
James Rinker - Reading PA, US
Michael Winters - Lancaster PA, US

Assignee:

Boehringer Ingelheim Pharmaceuticals, Inc. - Ridgefield CT

International Classification:

C07D 471/02
C07D 413/00

US Classification:

546122, 544127

Abstract:

Disclosed are compounds of formula (I):.

US Patent:

7767399, Aug 3, 2010

Filed:

Jan 27, 2006

Appl. No.:

11/795908

Inventors:

Jason C. Murphy - Ambler PA, US
David B. Boyd - Quakertown PA, US
Adam Joel Kristopeit - North Wales PA, US
Russel Jackson Lander - Lansdale PA, US
Michael Albert Winters - Doylestown PA, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

Methods of isolating clinical-grade plasmid DNA from manufacturing processes, including large-scale fermentation regimes, are disclosed which encompass alternatives to two core unit operations common to plasmid DNA purification processes. The novel upstream and downstream purification processes disclosed herein provide for reduced production costs and increase process robustness. Either or both of the purification processes disclosed herein may be used in combination with additional purification steps known in the art that are associated with DNA plasmid purification technology.

US Patent:

8633322, Jan 21, 2014

Filed:

Oct 28, 2010

Appl. No.:

12/914244

Inventors:

Michael H. Parker - Chalfont PA, US
Dennis J. Hlasta - Doylestown PA, US
Yifang Huang - Lansdale PA, US
Allen B. Reitz - Lansdale PA, US
Edward C. Lawson - Pipersville PA, US
Carsten Schubert - Phoenixville PA, US
Eric Strobel - Warrington PA, US
Brett A. Tounge - Blue Bell PA, US
Kimberly White - North Wales PA, US
Michael P. Winters - Morgantown PA, US
Shyamali Ghosh - Norristown PA, US

Assignee:

Janssen Pharmaceutica NV

International Classification:

A61K 31/445
C07D 211/40

US Classification:

546216, 514326

Abstract:

The present invention is directed to novel alkynyl derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1.