Michael J Wolf

US Patent:

7759099, Jul 20, 2010

Filed:

Mar 2, 2006

Appl. No.:

11/367006

Inventors:

Michael F. Wolf - Golden Valley MN, US
Laurie A. Yunker - Richfield MN, US
Paul V. Trescony - Champlin MN, US

Assignee:

Kips Bay Medical, Inc. - Minneapolis MN

International Classification:

C12N 11/08

US Classification:

435180, 435177, 435182, 435395, 435402, 623915, 623916

Abstract:

Apparatus and methods for seeding an implantable medical device, such as a vascular prosthesis, with cells, such as endothelial cells, are described. The invention supports techniques for seeding a luminal surface of the device with axial centrifugation. Cells are introduced in suspension into the lumen of the device. The introduction of the cells may occur after a blood centrifugation product, such as platelet-poor plasma, is applied to the luminal surface. After the cells are introduced, the device is then subjected to centrifugation around a longitudinal axis defined by the lumen. Axial centrifugation causes the cells to concentrate toward and adhere to the luminal surface. Shortly after axial centrifugation, the seeded device can be presented for implantation in a patient. The implantable medical device may be inserted into a protective sleeve prior to seeding the device with cells, and the sleeve may or may not be removed prior to implantation.

US Patent:

7759120, Jul 20, 2010

Filed:

Sep 1, 2006

Appl. No.:

11/515344

Inventors:

Michael F. Wolf - Golden Valley MN, US
Laurie A. Yunker - Richfield MN, US
Paul V. Trescony - Champlin MN, US

Assignee:

Kps Bay Medical, Inc. - Minneapolis MN

International Classification:

C12N 11/08

US Classification:

435395, 435177, 435180, 435182, 435402, 623915, 623916, 600 36

Abstract:

Apparatus and methods for seeding an implantable medical device, such as a vascular prosthesis, with cells, such as endothelial cells, are described. The invention supports techniques for seeding a luminal surface of the device with axial centrifugation. Cells are introduced in suspension into the lumen of the device. The introduction of the cells may occur after a blood centrifugation product, such as platelet-poor plasma, is applied to the luminal surface. After the cells are introduced, the device is then subjected to centrifugation around a longitudinal axis defined by the lumen. Axial centrifugation causes the cells to concentrate toward and adhere to the luminal surface. Shortly after axial centrifugation, the seeded device can be presented for implantation in a patient. The implantable medical device may be inserted into a protective sleeve prior to seeding the device with cells, and the sleeve may or may not be removed prior to implantation.

US Patent:

20060199265, Sep 7, 2006

Filed:

Mar 2, 2005

Appl. No.:

11/071597

Inventors:

Michael Wolf - Golden Valley MN, US
Laurie Yunker - Richfield MN, US
Paul Trescony - Champlin MN, US

International Classification:

C12N 5/00
C12N 5/02

US Classification:

435395000, 435325000

Abstract:

The invention is directed to apparatus and methods for seeding an implantable medical device, such as a vascular prosthesis, with cells, such as endothelial cells. The invention supports techniques for seeding a luminal surface of the device with axial centrifugation. Cells are introduced in suspension into the lumen of the device, and the device is subjected to centrifugation around a longitudinal axis defined by the lumen. Axial centrifugation causes the cells to concentrate toward the luminal surface. Shortly after axial centrifugation, the seeded device can be presented for implantation in a patient.

US Patent:

20090018386, Jan 15, 2009

Filed:

Sep 18, 2008

Appl. No.:

12/212782

Inventors:

Michael F. Wolf - Golden Valley MN, US
Laurie A. Yunker - Richfield MN, US
Paul V. Trescony - Champlin MN, US

International Classification:

A61F 2/04
A61F 2/82
A61F 2/24

US Classification:

600 36, 623 141, 623 242

Abstract:

The invention is directed to apparatus and methods for seeding an implantable medical device, such as a vascular prosthesis, with cells, such as endothelial cells. The invention supports techniques for seeding a luminal surface of the device with axial centrifugation. Cells are introduced in suspension into the lumen of the device, and the device is subjected to centrifugation around a longitudinal axis defined by the lumen. Axial centrifugation causes the cells to concentrate toward the luminal surface. Shortly after axial centrifugation, the seeded device can be presented for implantation in a patient.

US Patent:

52828476, Feb 1, 1994

Filed:

Jul 15, 1992

Appl. No.:

7/914648

Inventors:

Paul V. Trescony - Robbinsdale MN
Michael Wolf - Brooklyn Park MN
Richard L. Molacek - Maple Grove MN
Elaine Lindell - Blaine MN

Assignee:

Medtronic, Inc. - Minneapolis MN

International Classification:

A61F 206

US Classification:

623 1

Abstract:

A vascular graft having a pleated circumference accommodates blood pressure changes with minimal change in internal surface area. A highly compliant graft may be made from a wide variety of polymers including non-elastomeric materials.

US Patent:

52718980, Dec 21, 1993

Filed:

May 3, 1993

Appl. No.:

8/056450

Inventors:

Michael F. Wolf - Brooklyn Park MN
Paul V. Trescony - Champlin MN
James R. Keogh - Maplewood MN

Assignee:

Medtronic, Inc. - Minneapolis MN

International Classification:

G01N 3349

US Classification:

422 64

Abstract:

An apparatus designed to test blood, blood contacting biomaterials and devices such as materials and surface-modified materials; vascular grafts, stents, heart valves, catheters, leads, etc. , for blood and material responses in vitro under physiological blood flow conditions. The apparatus consists of a stepper-motor driven circular disc(s), upon which a test vehicle, containing either the test materials, coating or device, is mounted. The test vehicle itself consists of a circular, closed-loop of polymer tubing containing a check valve.

US Patent:

56537450, Aug 5, 1997

Filed:

Apr 27, 1995

Appl. No.:

8/429991

Inventors:

Paul V. Trescony - Robbinsdale MN
Michael Wolf - Brooklyn Park MN
Richard Molacek - Maple Grove MN
Elaine Lindell - Blaine MN

Assignee:

Medtronic, Inc. - Minneapolis MN

International Classification:

A61F 206
A61F 204

US Classification:

623 1

Abstract:

A vascular graft having a pleated circumference accommodates blood pressure changes with minimal change in internal surface area. A highly compliant graft may be made from a wide variety of polymers including non-elastomeric materials.

US Patent:

56074646, Mar 4, 1997

Filed:

Aug 27, 1993

Appl. No.:

8/113542

Inventors:

Paul V. Trescony - Robbinsdale MN
Michael Wolf - Brooklyn Park MN
Richard Molacek - Maple Grove MN
Elaine Lindell - Blaine MN

Assignee:

Medtronic, Inc. - Minneapolis MN

International Classification:

A61F 206
A61F 204

US Classification:

623 1

Abstract:

A vascular graft having a pleated circumference accommodates blood pressure changes with minimal change in internal surface area. A highly compliant graft may be made from a wide variety of polymers including non-elastomeric materials.