Michael J Wolf

US Patent:

7759099, Jul 20, 2010

Filed:

Mar 2, 2006

Appl. No.:

11/367006

Inventors:

Michael F. Wolf - Golden Valley MN, US
Laurie A. Yunker - Richfield MN, US
Paul V. Trescony - Champlin MN, US

Assignee:

Kips Bay Medical, Inc. - Minneapolis MN

International Classification:

C12N 11/08

US Classification:

435180, 435177, 435182, 435395, 435402, 623915, 623916

Abstract:

Apparatus and methods for seeding an implantable medical device, such as a vascular prosthesis, with cells, such as endothelial cells, are described. The invention supports techniques for seeding a luminal surface of the device with axial centrifugation. Cells are introduced in suspension into the lumen of the device. The introduction of the cells may occur after a blood centrifugation product, such as platelet-poor plasma, is applied to the luminal surface. After the cells are introduced, the device is then subjected to centrifugation around a longitudinal axis defined by the lumen. Axial centrifugation causes the cells to concentrate toward and adhere to the luminal surface. Shortly after axial centrifugation, the seeded device can be presented for implantation in a patient. The implantable medical device may be inserted into a protective sleeve prior to seeding the device with cells, and the sleeve may or may not be removed prior to implantation.

US Patent:

7759120, Jul 20, 2010

Filed:

Sep 1, 2006

Appl. No.:

11/515344

Inventors:

Michael F. Wolf - Golden Valley MN, US
Laurie A. Yunker - Richfield MN, US
Paul V. Trescony - Champlin MN, US

Assignee:

Kps Bay Medical, Inc. - Minneapolis MN

International Classification:

C12N 11/08

US Classification:

435395, 435177, 435180, 435182, 435402, 623915, 623916, 600 36

Abstract:

Apparatus and methods for seeding an implantable medical device, such as a vascular prosthesis, with cells, such as endothelial cells, are described. The invention supports techniques for seeding a luminal surface of the device with axial centrifugation. Cells are introduced in suspension into the lumen of the device. The introduction of the cells may occur after a blood centrifugation product, such as platelet-poor plasma, is applied to the luminal surface. After the cells are introduced, the device is then subjected to centrifugation around a longitudinal axis defined by the lumen. Axial centrifugation causes the cells to concentrate toward and adhere to the luminal surface. Shortly after axial centrifugation, the seeded device can be presented for implantation in a patient. The implantable medical device may be inserted into a protective sleeve prior to seeding the device with cells, and the sleeve may or may not be removed prior to implantation.

US Patent:

7998188, Aug 16, 2011

Filed:

May 4, 2007

Appl. No.:

11/797648

Inventors:

Peter Paul Zilla - Cape Town, ZA
Nasser Rafiee - Andover MA, US
Deon Bezuidenhout - Cape Town, ZA
Thomas Franz - Cape Town, ZA
Mark Yeoman - Forest Row Eash Sussex, GB
Hellmut Bowles - Bloubergrant, ZA
Nareak Douk - Lowell MA, US
Michael F. Wolf - Golden Valley MN, US
Paul Human - Cape Town, ZA

Assignee:

Kips Bay Medical, Inc. - Minneapolis MN

International Classification:

A61F 2/06

US Classification:

623 113, 623 115

Abstract:

Stents and methods of using stents are provided. Stents of the invention provide external support structure for a blood vessel segment disposed within, wherein the stents are capable of resilient radial expansion in a manner mimicking the compliance properties of an artery. The stent may be formed of a knitted or braided mesh formed so as to provide the needed compliance properties. A venous graft with the stent and a vein segment disposed within is provided, wherein graft is capable of mimicking the compliance properties of an artery. Methods of selecting stents for downsizing and methods of using the stents of the invention in downsizing and smoothening are provided. Methods of replacing a section of an artery with a venous graft including a stent of the invention are provided. Methods of reducing intimal hyperplasia in implanted vein segment in a venous graft using stents of the invention are provided.

US Patent:

8057537, Nov 15, 2011

Filed:

Apr 28, 2004

Appl. No.:

10/834360

Inventors:

Peter P. Zilla - Capetown, ZA
Nasser Rafiee - Andover MA, US
Deon Bezuidenhout - Capetown, ZA
Thomas Franz - Capetown, ZA
Mark Yeoman - Forest Row, GB
Hellmut Bowles - Bloubergrant, ZA
Nareak Douk - Lowell MA, US
Michael F. Wolf - Golden Valley MN, US

Assignee:

Kips Bay Medical, Inc. - Minneapolis MN

International Classification:

A61F 2/90

US Classification:

623 15, 623 113

Abstract:

A venous graft for replacement of a section of an artery and methods of making the graft. The graft comprises a flexible, resilient, generally tubular external support and a vein segment carried within and having an ablumenal surface in contact with and supported by the tubular support, the venous graft being capable of resilient radial expansion in a manner mimicking the radial compliance properties of an artery.

US Patent:

8172746, May 8, 2012

Filed:

Feb 19, 2009

Appl. No.:

12/388702

Inventors:

Peter P. Zilla - Capetown, ZA
Nasser Rafiee - Andover MA, US
Deon Bezuidenhout - Capetown, ZA
Thomas Franz - Capetown, ZA
Mark Yeoman - Forest Row, GB
Hellmut Bowles - Bloubergrant, ZA
Michael F. Wolf - Golden Valley MN, US

Assignee:

Kips Bay Medical, Inc. - Minneapolis MN

International Classification:

A61F 2/04

US Classification:

600 36, 623 113, 623 149

Abstract:

A venous graft for replacement of a section of an artery and methods of making the graft. The graft comprises a flexible, resilient, generally tubular external support and a vein segment carried within and having an ablumenal surface in contact with and supported by the tubular support, the venous graft being capable of resilient radial expansion in a manner mimicking the radial compliance properties of an artery.

US Patent:

8382814, Feb 26, 2013

Filed:

Aug 15, 2011

Appl. No.:

13/209517

Inventors:

Peter P. Zilla - Cape Town, ZA
Nasser Rafiee - Andover MA, US
Deon Bezuidenhout - Cape Town, ZA
Thomas Franz - Devils Peak, ZA
Mark Yeoman - East Sussex, GB
Hellmut Bowles - Bloubergrant, ZA
Nareak Douk - Lowell MA, US
Michael F Wolf - Golden Valley MN, US
Paul Human - Cape Town, ZA

Assignee:

Kips Bay Medical, Inc. - Minneapolis MN

International Classification:

A61F 2/06

US Classification:

623 113, 623 11

Abstract:

Stents and methods of using stents are provided. Stents of the invention provide external support structure for a blood vessel segment disposed within, wherein the stents are capable of resilient radial expansion in a manner mimicking the compliance properties of an artery. The stent may be formed of a knitted or braided mesh formed so as to provide the needed compliance properties. A venous graft with the stent and a vein segment disposed within is provided, wherein graft is capable of mimicking the compliance properties of an artery. Methods of selecting stents for downsizing and methods of using the stents of the invention in downsizing and smoothening are provided. Methods of replacing a section of an artery with a venous graft including a stent of the invention are provided. Methods of reducing intimal hyperplasia in implanted vein segment in a venous graft using stents of the invention are provided.

US Patent:

20050055085, Mar 10, 2005

Filed:

Sep 4, 2003

Appl. No.:

10/656855

Inventors:

Nicolas Rivron - Juvisy sur Orge, FR
Paul Trescony - Champlin MN, US
Michael Wolf - Golden Valley MN, US

International Classification:

A61F002/06

US Classification:

623001390, 623001410, 623921000

Abstract:

In general, the invention is directed to devices and methods that are useful for surface preparation of implantable medical devices. In the case of a vascular graft, the invention presents devices and methods that enhance endothelial cell seeding by providing recesses in the luminal surface that can receive endothelial cells. When the device is constructed of a material such as expanded polytetrafluoroethylene (ePTFE), the recesses may be created by physical processing of the microstructures of the material. The physical processing lifts nodes from the surface, forming recesses that can receive endothelial cells.

US Patent:

20050131520, Jun 16, 2005

Filed:

Nov 12, 2004

Appl. No.:

10/987313

Inventors:

Peter Zilla - Cape Town, ZA
Nasser Rafiee - Andover MA, US
Deon Bezuidenhout - Cape Town, ZA
Thomas Franz - Cape Town, ZA
Mark Yeoman - Lingfield, GB
Hellmut Bowles - Bloubergrant, ZA
Nareak Douk - Lowell MA, US
Michael Wolf - Golden Valley MN, US

International Classification:

A61F002/06

US Classification:

623001130, 623001410, 623901000

Abstract:

A graft for replacement of a section of an artery and methods of making the graft. The graft comprises a flexible, resilient, generally tubular external support and a blood vessel segment, e.g., a vein segment, carried within and having an ablumenal surface in contact with and supported by the tubular support, the graft being capable of resilient radial expansion in a manner mimicking the radial compliance properties of an artery.