Michelle Marion Barton

US Patent:

20100189725, Jul 29, 2010

Filed:

Jul 3, 2008

Appl. No.:

12/667314

Inventors:

Michelle Barton - Houston TX, US

International Classification:

A61K 31/713
C12Q 1/00
C12Q 1/68
C07H 21/02
A61K 31/7088
A61K 39/395
A61K 38/16
A61K 31/715
A61P 35/00
A61P 35/02

US Classification:

4241741, 435 4, 435 6, 536 245, 514 44 A, 514 44 R, 514 8, 514 54, 514 12

Abstract:

Methods of screening for modulators of TRIM24 (also known as TIF1-ALPHA) expression and/or biological activity are described. In particular, methods of screening of screening for modulators of TRIM24 E3 ligase activity, and specifically an E3 ligase activity directed at p53 as the target polypeptide are also described. Modulators of TRIM24 expression and activity are provided and their use in treatment of cancer, particularly in breast, colon, prostate, renal cancers and in acute lymphoblastic leukaemia. Suitable modulators of TRIM24 expression include siRNA and shRNA and can be used in the treatment of cancer and for targeting cancer stem cells.

US Patent:

20130045214, Feb 21, 2013

Filed:

Jun 25, 2012

Appl. No.:

13/532360

Inventors:

Michelle Barton - Houston TX, US

International Classification:

A61K 31/7088
A61K 31/713
A61P 35/02
A61K 31/7105
A61K 39/395
A61P 35/00
A61K 31/715
A61K 38/02

US Classification:

4241581, 514 44 A, 514 54, 514 193, 514 194, 514 195, 514 196

Abstract:

Methods of screening for modulators of TRIM24 (also known as TIF1-ALPHA) expression and/or biological activity are described. In particular, methods of screening for modulators of TRIM24 E3 ligase activity, and specifically an E3 ligase activity directed at p53 as the target polypeptide are also described. Modulators of TRIM24 expression and activity are provided and their use in treatment of cancer, particularly in breast, colon, prostate, renal cancers and in acute lymphoblastic leukemia. Suitable modulators of TRIM24 expression include siRNA and shRNA and can be used in the treatment of cancer and for targeting cancer stem cells.