Michelle R Curtis

US Patent:

7150982, Dec 19, 2006

Filed:

Feb 26, 2002

Appl. No.:

10/084839

Inventors:

Hatim T. Allawi - Madison WI, US
Brad T. Argue - Sun Prairie WI, US
Christian Tor Bartholomay - Madison WI, US
LuAnne Chehak - Janesville WI, US
Michelle L. Curtis - Cottage Grove WI, US
Peggy S. Eis - San Diego CA, US
Jeff G. Hall - Madison WI, US
Hon S. Ip - Madison WI, US
Lin Ji - Madison WI, US
Michael W. Kaiser - Madison WI, US
Robert W. Kwiatkowski - Verona WI, US
Andrew A. Lukowiak - Stoughton WI, US
Victor Lyamichev - Madison WI, US
WuPo Ma - Madison WI, US
Bruce P. Neri - Carlsbad CA, US
Sarah M. Olson - Cross Plains WI, US
James J. Schaefer - Madison WI, US
Zbigniev Skrzypczynski - Verona WI, US
Tsetska Y. Takova - Madison WI, US
Lisa C. Thompson - Madison WI, US
Kevin L. Vedvik - Madison WI, US

Assignee:

Third Wave Technologies, Inc. - Madison WI

International Classification:

C12N 9/22

US Classification:

435199, 435 6

Abstract:

The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In some embodiments, the 5′ nuclease activity of a variety of enzymes is used to cleave a target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.

US Patent:

7807806, Oct 5, 2010

Filed:

Oct 30, 2007

Appl. No.:

11/929404

Inventors:

Hatim T. Allawi - Madison WI, US
Brad T. Argue - Sun Prairie WI, US
Christian Tor Bartholomay - Ames IA, US
LuAnne Chehak - Janesville WI, US
Michelle L. Curtis - Cottage Grove WI, US
Peggy S. Eis - Fitchburg WI, US
Jeff G. Hall - Waunakee WI, US
Hon S. Ip - Madison WI, US
Lin Ji - Madison WI, US
Michael W. Kaiser - Madison WI, US
Robert W. Kwiatkowski - Hopewell Junction NY, US
Andrew A. Lukowiak - Stoughton WI, US
Victor Lyamichev - Madison WI, US
Wupo Ma - Madison WI, US
Bruce P. Neri - Carlsbad CA, US
Sarah M. Olson - Cross Plains WI, US
James J. Schaefer - Madison WI, US
Zbigniev Skrzypczynski - Verona WI, US
Tsetska Y. Takova - Madison WI, US
Lisa C. Thompson - Madison WI, US
Kevin L. Vedvik - Madison WI, US

Assignee:

Third Wave Technologies, Inc. - Madison WI

International Classification:

C07H 21/04
C07K 14/00

US Classification:

536 231, 530350

Abstract:

The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In some embodiments, the 5′ nuclease activity of a variety of enzymes is used to cleave a target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.

US Patent:

7935800, May 3, 2011

Filed:

Dec 19, 2006

Appl. No.:

11/642815

Inventors:

Hatim T. Allawi - Madison WI, US
Brad T. Argue - Sun Prairie WI, US
Christian Tor Bartholomay - Madison WI, US
LuAnne Chehak - Janesville WI, US
Michelle L. Curtis - Cottage Grove WI, US
Peggy S. Eis - San Diego CA, US
Jeff G. Hall - Madison WI, US
Hon S. Ip - Madison WI, US
Lin Ji - Madison WI, US
Michael W. Kaiser - Madison WI, US
Robert W. Kwiatkowski - Verona WI, US
Andrew A. Lukowiak - Stoughton WI, US
Victor Lyamichev - Madison WI, US
WuPo Ma - Madison WI, US
Bruce P. Neri - Carlsbad CA, US
Sarah M. Olson - Cross Plains WI, US
James J. Schaefer - Madison WI, US
Zbigniev Skrzypczynski - Verona WI, US
Tsetska Y Takova - Madison WI, US
Lisa C. Thompson - Madison WI, US
Kevin L. Vedvik - Madison WI, US

Assignee:

Third Wave Technologies, Inc. - Madison WI

International Classification:

C07H 21/02
C12Q 1/68
C07K 1/00

US Classification:

536 231, 435 6, 530350

Abstract:

The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In some embodiments, the 5′ nuclease activity of a variety of enzymes is used to cleave a target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.

US Patent:

8063184, Nov 22, 2011

Filed:

Oct 5, 2010

Appl. No.:

12/898490

Inventors:

Hatim Allawi - Madison WI, US
Brad T. Argue - Sun Prairie WI, US
Christian Tor Bartholomay - Madison WI, US
LuAnne Chehak - Janesville WI, US
Michelle L. Curtis - Cottage Grove WI, US
Peggy S. Eis - Madison WI, US
Jeff G. Hall - Madison WI, US
Hon S. Ip - Madison WI, US
Lin Ji - Madison WI, US
Michael Kaiser - Madison WI, US
Andrew A. Lukowiak - Stoughton WI, US
Victor Lyamichev - Madison WI, US
WuPo Ma - Madison WI, US
Bruce P. Neri - Madison WI, US
Sarah M. Olson - Cross Plains WI, US
James J. Schaefer - Madison WI, US
Zbigniev Skrzypczynski - Verona WI, US
Tsetska Y. Takova - Madison WI, US
Lisa C. Thompson - Madison WI, US
Kevin L. Vedvik - Madison WI, US

Assignee:

Third Wave Technologies, Inc. - Madison WI

International Classification:

C07K 14/00
C12N 15/00

US Classification:

530350, 435 691

Abstract:

The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In some embodiments, the 5′ nuclease activity of a variety of enzymes is used to cleave a target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.

US Patent:

20030104378, Jun 5, 2003

Filed:

May 24, 2001

Appl. No.:

09/864636

Inventors:

Hatim Allawi - Madison WI, US
Christian Bartholomay - Madison WI, US
LuAnne Chehak - Janesville WI, US
Michelle Curtis - Cottage Grove WI, US
Peggy Eis - Madison WI, US
Jeff Hall - Madison WI, US
Hon Ip - Madison WI, US
Michael Kaiser - Madison WI, US
Robert Kwiatkowski - Verona WI, US
Andrew Lukowiak - Madison WI, US
Victor Lyamichev - Madison WI, US
WuPo Ma - Madison WI, US
Sarah Olson - Cross Plains WI, US
James Schaefer - Madison WI, US
Zbigniew Skrzypczynski - Verona WI, US
Tsetska Takova - Madison WI, US
Kevin Vedvik - Madison WI, US
Natalie Lyamichev - Madison WI, US
Burce Neri - Madison WI, US

Assignee:

Third Wave Technologies, Inc. - Madison WI

International Classification:

C12Q001/68
C12P019/34

US Classification:

435/006000, 435/091200

Abstract:

The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In some embodiments, the 5′ nuclease activity of a variety of enzymes is used to cleave a target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.

US Patent:

20070087345, Apr 19, 2007

Filed:

Jul 9, 2004

Appl. No.:

10/564136

Inventors:

Michelle Curtis - Cottage Grove WI, US
Kyle Armantrout - Los Angeles CA, US
Feng Cao - Milwaukee WI, US
Bonnie Hurwitz - Madison WI, US
Daniel Machmeier - Middleton WI, US
Sara Olson - Cross Plains WI, US
Hon Ip - Madison WI, US
Robert Kwiatkowski Jr - Verona WI, US
LuAnne Chehak - Janesville WI, US

Assignee:

THIRD WAVE TECHNOLOGIES, INC. - Madison WI

International Classification:

C12Q 1/68

US Classification:

435006000

Abstract:

The present invention relates to compositions, methods, and kits for quantifying variations in gene copy number, e.g., of individual genes or of chromosomes or portions of chromosomes in an homogeneous reaction, without the need for target amplification, fragment size resolution, or microscopy.