Michelle D Hall

US Patent:

20230104080, Apr 6, 2023

Filed:

Aug 1, 2022

Appl. No.:

17/816696

Inventors:

- Cambridge MA, US
Kanchana Ravichandran - Cambridge MA, US
Amy E. Rabideau - Waltham MA, US
Margaret Franklin - Cambridge MA, US
Kevin Smith - Cambridge MA, US
Michelle Lynn Hall - Roxbury MA, US

Assignee:

ModernaTX, Inc. - Cambridge MA

International Classification:

C12N 9/12
C12P 19/34

Abstract:

The present disclosure provides RNA polymerase variants for high efficiency transcription.

US Patent:

20180064666, Mar 8, 2018

Filed:

Mar 10, 2016

Appl. No.:

15/557731

Inventors:

Kun Ping Lu - Newton MA, US
Xiao Zhen Zhou - Newton MA, US
Shuo Wei - Chestnut Hill MA, US
Lijun Sun - Harvard MA, US
Michelle Lynn Hall - Somerville MA, US
- Boston MA, US
- Concord MA, US

International Classification:

A61K 31/196
A61K 31/4166
A61K 31/4192
A61K 31/4152
A61K 31/4245
A61K 31/452
A61K 31/5375
A61K 31/122
A61K 45/06

Abstract:

The invention features all-trans retinoic acid (ATRA)-related compounds capable of associating with Pin1 and methods of treating a proliferative disorder characterized by elevated Pin1 marker levels, Pin1 degradation, and/or reduced Pin1 Ser71 phosphorylation in a subject by administering an ATRA-related compound. The invention also features methods of treating proliferative disorders, autoimmune diseases, and addiction conditions (e.g., diseases, disorders, and conditions characterized by elevated Pin1 marker levels) by administering an ATRA-related compound in combination with another therapeutic compound.