Michelle N Nelson

US Patent:

7468418, Dec 23, 2008

Filed:

Apr 29, 2004

Appl. No.:

10/836804

Inventors:

Patrick L. Iversen - Corvallis OR, US
Hong M. Moulton - Corvallis OR, US
Michelle H. Nelson - Corvallis OR, US
Andrew D. Kroeker - Corvallis OR, US
David A. Stein - Corvallis OR, US

Assignee:

AVI BioPharma., Inc. - Corvallis OR

International Classification:

C07K 7/08
C07H 21/04
C08B 15/06

US Classification:

530300, 536 245, 536 31

Abstract:

Compositions and methods for enhancing delivery of molecules, e. g. biological agents, into cells are described. The composition is a conjugate of the biological agent, preferably a nucleic acid analog having a substantially uncharged backbone, covalently linked to a peptide transporter moiety as described. Conjugation of the peptide transporter to a substantially uncharged nucleic acid analog, such as a morpholino oligomer, is also shown to enhance binding of the oligomer to its target sequence and enhance antisense activity.

US Patent:

20090082547, Mar 26, 2009

Filed:

Nov 5, 2008

Appl. No.:

12/265499

Inventors:

Patrick L. Iversen - Corvallis OR, US
Hong M. Moulton - Corvallis OR, US
Michelle H. Nelson - Corvallis OR, US
Andrew D. Kroeker - Corvallis OR, US
David A. Stein - Corvallis OR, US

International Classification:

C07K 7/00

US Classification:

530322

Abstract:

Compositions and methods for enhancing delivery of molecules, e.g. biological agents, into cells are described. The composition is a conjugate of the biological agent, preferably a nucleic acid analog having a substantially uncharged backbone, covalently linked to a peptide transporter moiety as described. Conjugation of the peptide transporter to a substantially uncharged nucleic acid analog, such as a morpholino oligomer, is also shown to enhance binding of the oligomer to its target sequence and enhance antisense activity.

US Patent:

20200016280, Jan 16, 2020

Filed:

Apr 9, 2019

Appl. No.:

16/379046

Inventors:

- CAMBRIDGE MA, US
Hong M. Moulton - Corvallis OR, US
Michelle H. Nelson - Corvallis OR, US
David A. Stein - Corvallis OR, US
Andrew D. Kroeker - Cambridge MA, US

International Classification:

A61K 49/00
C12N 15/113
C12N 15/87
A61K 47/64

Abstract:

Compositions and methods for enhancing delivery of molecules, e.g. biological agents, into cells are described. The composition is a conjugate of the biological agent, preferably a nucleic acid analog having a substantially uncharged backbone, covalently linked to a peptide transporter moiety as described. Conjugation of the peptide transporter to a substantially uncharged nucleic acid analog, such as a morpholino oligomer, is also shown to enhance binding of the oligomer to its target sequence and enhance antisense activity.

US Patent:

20170368203, Dec 28, 2017

Filed:

Jan 10, 2017

Appl. No.:

15/402449

Inventors:

- Corvallis OR, US
Hong M. Moulton - Corvallis OR, US
Michelle H. Nelson - Corvallis OR, US
David A. Stein - Corvallis OR, US

International Classification:

A61K 49/00
C12N 15/87
A61K 47/64
C12N 15/113

Abstract:

Compositions and methods for enhancing delivery of molecules, e.g. biological agents, into cells are described. The composition is a conjugate of the biological agent, preferably a nucleic acid analog having a substantially uncharged backbone, covalently linked to a peptide transporter moiety as described. Conjugation of the peptide transporter to a substantially uncharged nucleic acid analog, such as a morpholino oligomer, is also shown to enhance binding of the oligomer to its target sequence and enhance antisense activity.